Male genital lichen sclerosus and filaggrin
T.N. Shim S. Brown N.D. Francis M. Dinneen D. Hawkins A. Muneer S. Minhas I. McLean C.B. Bunker
First published: 17 June 2019 https://doi.org/10.1111/ced.14023
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/ced.14023
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Abstract
Lichen sclerosus (LSc) is an acquired cutaneous disease of contentious aetiology. The majority of male cases involve the genitalia. Amongst prior postulated pathogenic factors in genital (G)LSc are infection, autoimmunity and genetic and environmental influences.1 There is an arguement that male (M)GLSc might be due to chronic occluded exposure of susceptible epithelium to urine. GLSc has also been associated with atopy.2 Filaggrin is a key epithelial protein expressed during terminal differentiation of the epidermis, forming a component of the epithelial barrier.
T.N. Shim S. Brown N.D. Francis M. Dinneen D. Hawkins A. Muneer S. Minhas I. McLean C.B. Bunker
First published: 17 June 2019 https://doi.org/10.1111/ced.14023
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/ced.14023
ePDFPDFTOOLS SHARE
Abstract
Lichen sclerosus (LSc) is an acquired cutaneous disease of contentious aetiology. The majority of male cases involve the genitalia. Amongst prior postulated pathogenic factors in genital (G)LSc are infection, autoimmunity and genetic and environmental influences.1 There is an arguement that male (M)GLSc might be due to chronic occluded exposure of susceptible epithelium to urine. GLSc has also been associated with atopy.2 Filaggrin is a key epithelial protein expressed during terminal differentiation of the epidermis, forming a component of the epithelial barrier.
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