Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta‐analysis
Kyriaki Seremidi MSc  Dimitrios Kloukos Dr Med Dent  Argy Polychronopoulou PhD  Antonis Kattamis PhD  Katerina Kavvadia PhD
First published: 22 June 2019 https://doi.org/10.1002/hed.25840
Section Editor: David Eisele
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Abstract
Background
This systematic review summarizes the prevalence of dental defects after chemo and radiation therapy and correlates the findings with specific characteristics of each treatment modality.

Methods
Database search was performed for studies reporting dental late effects of chemo and radiation therapy. After data extraction and risk of bias assessment, prevalence of crown and root defects was assessed. Correlations between each defect and the characteristics of the antineoplastic treatment were performed.

Results
Sixteen nonrandomized studies were included, yielding a total of 1300 patients with a mean age at diagnosis of 4.5 years. Results reported that root defects were more common than crown defects. The most common root defect was impaired root growth and microdontia the most common crown defect. Age, radiation dose and field were statistically associated with higher prevalence of dental defects.

Conclusion
Defects were associated with combination of chemotherapy and radiotherapy, as used in current therapeutic antineoplastic modalities.