Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study

Oncogenic NTRK gene fusions encoding constitutively activated TRK tyrosine kinases occur across a wide range of tumours. Larotrectinib is a first-in-class potent and highly selective inhibitor of TRK kinases. In this first-in-human, phase I dose-escalation study, we showed that larotrectinib was well tolerated and provided consistent and durable antitumour activity in adults with TRK fusion cancer.