International Immunopharmacology,

Anti-inflammatory effects of linalool on ovalbumin-induced pulmonary inflammation

Publication date: September 2019Source: International Immunopharmacology, Volume 74Author(s): Min-Gu Kim, Seong-Man Kim, Jae-Hong Min, Ok-Kyoung Kwon, Mi-Hyeong Park, Ji-Won Park, Hye In Ahn, Jeong-Yeon Hwang, Sei-Raying Oh, Jae-Won Lee, Kyung-Seop AhnAbstractLinalool is a natural product present in fruits and aromatic plants with biological activities. Researchers have reported that the inhalation of linalool exerts anti-inflammatory activities. In this study, we examined the therapeutic effects...

ScienceDirect Publication: International Immunopharmacology

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Dexmedetomidine ameliorates LPS induced acute lung injury via GSK-3β/STAT3-NF-κB signaling pathway in rats

Publication date: September 2019Source: International Immunopharmacology, Volume 74Author(s): Huayun Zhang, Jichen Sha, Xiujing Feng, Xueyuan Hu, Yongping Chen, Bei Li, Honggang FanAbstractAcute lung injury (ALI) is a serious complication of sepsis and an important cause of death in intensive care. Studies have shown that DEX can inhibit inflammation. However, the anti-inflammatory effect and protective mechanism of DEX in lipopolysaccharide (LPS) induced ALI are still unclear. ALI model was established...

ScienceDirect Publication: International Immunopharmacology

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Chimeric antigen receptor (CAR)-modified NK cells against cancer: Opportunities and challenges

Publication date: September 2019Source: International Immunopharmacology, Volume 74Author(s): Luyao Wang, Mei Dou, Qingxia Ma, Ruixue Yao, Jia LiuAbstractNK cells may have great potential in tumor immunotherapy because they can kill tumor cells directly and quickly. Chimeric antigen receptor is a fusion protein composed of extracellular antigen recognition domain, transmembrane domain and intracellular signal domain. Rapid development of CAR-modified T cells has made tremendous achievements in the...

ScienceDirect Publication: International Immunopharmacology

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Implications of soluble E-cadherin level of antiviral treatment in patients with chronic hepatitis C virus infection

Publication date: September 2019Source: International Immunopharmacology, Volume 74Author(s): Ze-Rong Wang, Hui Chen, Shang-Shang Gao, Hao Qiu, Han-Wen Li, Zi-Ling Sun, Jia-Min WangAbstractBackground and aimsSoluble E-cadherin (sE-cadherin) has been observed elevated in patients with various diseases, and implicated in the occurrence and development of those diseases. The implications of sE-cadherin in chronic hepatitis C virus (HCV) infection are still unclear. The purpose of this study is to explore...

ScienceDirect Publication: International Immunopharmacology

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TUDCA attenuates intestinal injury and inhibits endoplasmic reticulum stress-mediated intestinal cell apoptosis in necrotizing enterocolitis

Publication date: September 2019Source: International Immunopharmacology, Volume 74Author(s): Peng Li, Dong Fu, Qingfeng Sheng, Shenghua Yu, Xingqi Bao, Zhibao LvAbstractNeonatal necrotizing enterocolitis (NEC) is a life-threatening disease with severe inflammation and intestinal cell apoptosis. Tauroursodeoxycholic acid (TUDCA) is a recognized endoplasmic reticulum stress (ERS) inhibitor which can inhibit cell apoptosis. Recently, intestinal cell apoptosis has been demonstrated to be vital for the...

ScienceDirect Publication: International Immunopharmacology

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Heme oxygenase-1 attenuates seawater drowning-induced acute lung injury through a reduction in inflammation and oxidative stress

Publication date: September 2019Source: International Immunopharmacology, Volume 74Author(s): Xue-qian Sun, Chen Wu, Yu-bao Qiu, Ya-Xian Wu, Jun-liang Chen, Jian-feng Huang, Dan Chen, Qing-feng PangAbstractObjectiveHeme oxygenase-1 (HO-1) plays a critical protective role in various insults-induced acute lung injury (ALI) through its strong anti-inflammatory, anti-oxidant, and anti-apoptotic properties, but its protective role and mechanism on seawater aspiration-induced acute lung injury remains...

ScienceDirect Publication: International Immunopharmacology

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