E‐cigarettes and head and neck cancers: A systematic review of the current literature
Susanne Flach Pavithran Maniam Jaiganesh Manickavasagam
First published: 30 May 2019 https://doi.org/10.1111/coa.13384
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/coa.13384
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Abstract
Background
Cigarette smoking is a well established risk factor for head and neck (HN) cancers. Use of electronic cigarettes (e‐cigarettes) is gaining popularity, being advertised as benign alternatives to tobacco. A wide variety of potentially harmful chemical components with variable quantity have been identified in e‐liquids and aerosols of e‐cigarettes. However, use of e‐cigarettes remains controversial due to conflicting evidence.
Objectives
We aimed to assess the association between e‐cigarettes and HN cancers. We conducted a systematic review to evaluate the literature for evidence on carcinogenic effects of e‐cigarettes in the pathogenesis of HN cancers.
Type of review
Qualitative systematic review.
Search strategy
A Pubmed/Medline, Cochrane, CINAHL Plus, Trip medical database and Web of Science search was done for studies on e‐cigarettes and HN cancer.
Evaluation method
Abstract review of all articles, full article revision of included studies, data extraction and quality assessment was performed by two independent assessors.
Results
The literature search resulted in the identification of 359 articles. Eighteen articles were selected for inclusion into the systematic review. The majority were laboratory‐based studies, followed by several cohort and case studies, representing low‐level evidence. A few reports suggested DNA‐damage following exposure to e‐cigarettes potentially due to increased oxidative stress. Flavoured e‐liquids appear to be more harmful. There is variable evidence from clinical studies.
Conclusions
Our review outlines potential dangers associated with the use of e‐cigarettes and their role in HN cancers. More longitudinal and controlled studies are needed to assess the possible link between e‐cigarettes and HN cancers.
This article is protected by copyright. All rights reserved.
Susanne Flach Pavithran Maniam Jaiganesh Manickavasagam
First published: 30 May 2019 https://doi.org/10.1111/coa.13384
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/coa.13384
ePDFPDFTOOLS SHARE
Abstract
Background
Cigarette smoking is a well established risk factor for head and neck (HN) cancers. Use of electronic cigarettes (e‐cigarettes) is gaining popularity, being advertised as benign alternatives to tobacco. A wide variety of potentially harmful chemical components with variable quantity have been identified in e‐liquids and aerosols of e‐cigarettes. However, use of e‐cigarettes remains controversial due to conflicting evidence.
Objectives
We aimed to assess the association between e‐cigarettes and HN cancers. We conducted a systematic review to evaluate the literature for evidence on carcinogenic effects of e‐cigarettes in the pathogenesis of HN cancers.
Type of review
Qualitative systematic review.
Search strategy
A Pubmed/Medline, Cochrane, CINAHL Plus, Trip medical database and Web of Science search was done for studies on e‐cigarettes and HN cancer.
Evaluation method
Abstract review of all articles, full article revision of included studies, data extraction and quality assessment was performed by two independent assessors.
Results
The literature search resulted in the identification of 359 articles. Eighteen articles were selected for inclusion into the systematic review. The majority were laboratory‐based studies, followed by several cohort and case studies, representing low‐level evidence. A few reports suggested DNA‐damage following exposure to e‐cigarettes potentially due to increased oxidative stress. Flavoured e‐liquids appear to be more harmful. There is variable evidence from clinical studies.
Conclusions
Our review outlines potential dangers associated with the use of e‐cigarettes and their role in HN cancers. More longitudinal and controlled studies are needed to assess the possible link between e‐cigarettes and HN cancers.
This article is protected by copyright. All rights reserved.
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