Clinical Cancer Research Online First Articles,

Nivolumab in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: Efficacy and Safety in CheckMate 141 by Prior Cetuximab Use

Purpose: Cetuximab, which modulates immune responses, may affect the efficacy of subsequent immunotherapy. Here, we assessed outcomes with nivolumab, by prior cetuximab exposure, in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) who had experienced progression within 6 months of platinum-containing chemotherapy. Experimental Design: In the randomized, open-label, phase III CheckMate 141 trial, patients were randomized 2:1 to nivolumab 3 mg/kg every...

Clinical Cancer Research Online First Articles

2h

VEGFR1+ metastasis-associated macrophages contribute to metastatic angiogenesis and influence colorectal cancer patient outcome

Purpose: To investigate the clinical relevance of macrophages in liver metastasis of colorectal cancer and their influence on angiogenesis and patient survival. Moreover, to evaluate specific blood monocytes as markers of disease recurrence. Experimental Design: In a mouse model with spontaneous LM, the angiogenic characteristics of tumor- (TAMs) and metastasis- (MAMs) associated macrophages were evaluated. Macrophages and the vasculature from 130 primary tumor (pTU) and 123 liver metastasis (LM)...

Clinical Cancer Research Online First Articles

2h