Purpose: Cetuximab, which modulates immune responses, may affect the efficacy of subsequent immunotherapy. Here, we assessed outcomes with nivolumab, by prior cetuximab exposure, in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) who had experienced progression within 6 months of platinum-containing chemotherapy. Experimental Design: In the randomized, open-label, phase III CheckMate 141 trial, patients were randomized 2:1 to nivolumab 3 mg/kg every...
Purpose: To investigate the clinical relevance of macrophages in liver metastasis of colorectal cancer and their influence on angiogenesis and patient survival. Moreover, to evaluate specific blood monocytes as markers of disease recurrence. Experimental Design: In a mouse model with spontaneous LM, the angiogenic characteristics of tumor- (TAMs) and metastasis- (MAMs) associated macrophages were evaluated. Macrophages and the vasculature from 130 primary tumor (pTU) and 123 liver metastasis (LM)...
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