Chronic Pulmonary Aspergillosis in a Tertiary Care Center in Spain: A Retrospective, Observational Study
Juan Aguilar‐Company María Teresa Martín Lidia Goterris‐Bonet Alex Martinez‐Marti Júlia Sampol Elisa Roldán Benito Almirante Isabel Ruiz‐Camps
First published: 04 June 2019 https://doi.org/10.1111/myc.12950
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/myc.12950
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Abstract
Objective
The aim of this study was to describe the characteristics of patients with chronic pulmonary aspergillosis (CPA) in a tertiary care center in Spain.
Patients and methods
Retrospective cohort study of all patients diagnosed with CPA between January 2010 and December 2015. The patients were identified through the Microbiology registry. Demographic, clinical, laboratory, radiological, microbiological and clinical data were recorded. Patients were followed up for 12 months.
Results
53 patients were included; median age was 61.5 years. Forty‐seven had a lung condition, 25 suffered from COPD, 19 an active malignancy, 10 had previous pulmonary tuberculosis and 9 lung insterstitial disease. Twenty‐eight patients presented with chronic cavitary pulmonary form (CCPA) and 20 with subacute invasive aspergillosis (SAIA). Species identified were A. fumigatus (34), A. niger (5), A. terreus (4) and A. flavus (3). All‐cause 1 year mortality was 56%. Predictors of mortality were cancer history (OR, 9.5; 95% CI, 2.54‐35.51; p<0.01) and SAIA (OR, 5.49; 95% CI, 1.49‐19.82; p<0.01). Previous pulmonary tuberculosis, surgery for the treatment of CPA, and CCPA were found to be associated with lower mortality (OR, 0.05; 95% CI, <0.01‐0.47; p<0.01; OR, 0.16; 95% CI, 0.03‐0.88; p=0.035 and OR 0.2, 95% CI, 0.01‐0.67; p=0.01, respectively).
Conclusions
This is the first study providing an overview of the features of CPA in patients from Spain. CCPA was the most frequent form of CPA and A. fumigatus the most frequently isolated species. Patients with cancer history and SAIA had a worse prognosis.
Juan Aguilar‐Company María Teresa Martín Lidia Goterris‐Bonet Alex Martinez‐Marti Júlia Sampol Elisa Roldán Benito Almirante Isabel Ruiz‐Camps
First published: 04 June 2019 https://doi.org/10.1111/myc.12950
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/myc.12950
ePDFPDFTOOLS SHARE
Abstract
Objective
The aim of this study was to describe the characteristics of patients with chronic pulmonary aspergillosis (CPA) in a tertiary care center in Spain.
Patients and methods
Retrospective cohort study of all patients diagnosed with CPA between January 2010 and December 2015. The patients were identified through the Microbiology registry. Demographic, clinical, laboratory, radiological, microbiological and clinical data were recorded. Patients were followed up for 12 months.
Results
53 patients were included; median age was 61.5 years. Forty‐seven had a lung condition, 25 suffered from COPD, 19 an active malignancy, 10 had previous pulmonary tuberculosis and 9 lung insterstitial disease. Twenty‐eight patients presented with chronic cavitary pulmonary form (CCPA) and 20 with subacute invasive aspergillosis (SAIA). Species identified were A. fumigatus (34), A. niger (5), A. terreus (4) and A. flavus (3). All‐cause 1 year mortality was 56%. Predictors of mortality were cancer history (OR, 9.5; 95% CI, 2.54‐35.51; p<0.01) and SAIA (OR, 5.49; 95% CI, 1.49‐19.82; p<0.01). Previous pulmonary tuberculosis, surgery for the treatment of CPA, and CCPA were found to be associated with lower mortality (OR, 0.05; 95% CI, <0.01‐0.47; p<0.01; OR, 0.16; 95% CI, 0.03‐0.88; p=0.035 and OR 0.2, 95% CI, 0.01‐0.67; p=0.01, respectively).
Conclusions
This is the first study providing an overview of the features of CPA in patients from Spain. CCPA was the most frequent form of CPA and A. fumigatus the most frequently isolated species. Patients with cancer history and SAIA had a worse prognosis.
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