Characterization of circadian human facial surface lipid composition
Yan Jia Mingyue Zhou Hong Huang Yao Gan Manli Yang Ruiheng Ding
First published: 10 April 2019 https://doi.org/10.1111/exd.13933 Cited by: 1
Funding information:
This work was supported by National Natural Science Foundation of China (31501415); the Open Research Fund Program of Key Laboratory of Cosmetic (Beijing Technology and Business University), China National Light Industry; grants from Support Project of High‐level Teachers in Beijing Municipal Universities in the Period of 13th Five‐year Plan (CIT&TCD201804027); grants from Science and Technology Planning Project of Beijing (Z171100001517006).
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Abstract
Background
The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at the physiological level; however, few studies at the molecular level have been reported. Additionally, there is no study on lipidomic profile variations of skin surface lipid (SSL), which could potentially explain the rhythmic changes in skin status.
Objectives
The SSL profile of healthy young women was analysed to assess SSL variations and to assess the skin status during the circadian cycle.
Methods
Ultra performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry and multivariate data analysis were performed to assess SSL variations.
Results
The lipidomic profile showed significant differences with the circadian rhythm. Multivariate data analysis indicated that glycerolipids were the lipids majorly affected by the circadian rhythm. Additionally, in the SSL profile, both the average chain length and the content of free fatty acids (FFAs) were higher at 20:00 than at 08:00.
Conclusions
The SSL profile significantly varied with respect to the circadian rhythm. The rhythm‐altered triacylglycerol level, FFA chain length and FFA content resulted in rhythmic changes in skin barrier function, including transepidermal water loss alteration and pH variation.
Yan Jia Mingyue Zhou Hong Huang Yao Gan Manli Yang Ruiheng Ding
First published: 10 April 2019 https://doi.org/10.1111/exd.13933 Cited by: 1
Funding information:
This work was supported by National Natural Science Foundation of China (31501415); the Open Research Fund Program of Key Laboratory of Cosmetic (Beijing Technology and Business University), China National Light Industry; grants from Support Project of High‐level Teachers in Beijing Municipal Universities in the Period of 13th Five‐year Plan (CIT&TCD201804027); grants from Science and Technology Planning Project of Beijing (Z171100001517006).
Read the full text
ePDFPDFTOOLS SHARE
Abstract
Background
The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at the physiological level; however, few studies at the molecular level have been reported. Additionally, there is no study on lipidomic profile variations of skin surface lipid (SSL), which could potentially explain the rhythmic changes in skin status.
Objectives
The SSL profile of healthy young women was analysed to assess SSL variations and to assess the skin status during the circadian cycle.
Methods
Ultra performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry and multivariate data analysis were performed to assess SSL variations.
Results
The lipidomic profile showed significant differences with the circadian rhythm. Multivariate data analysis indicated that glycerolipids were the lipids majorly affected by the circadian rhythm. Additionally, in the SSL profile, both the average chain length and the content of free fatty acids (FFAs) were higher at 20:00 than at 08:00.
Conclusions
The SSL profile significantly varied with respect to the circadian rhythm. The rhythm‐altered triacylglycerol level, FFA chain length and FFA content resulted in rhythmic changes in skin barrier function, including transepidermal water loss alteration and pH variation.
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