Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastases

Genomic characterisation of tumour tissue has been established as crucial for state-of-the-art diagnostic and therapeutic approaches to cancer. However, characterisation of cancer is challenged by constitutive and evolving intra-tumour and inter-lesion heterogeneity, which requires thorough and continuous analysis of genomic complexity over time.