Abstract In 2007, human papillomavirus (HPV) type 16 was finally recognized as a risk factor, besides smoking and alcohol, for oropharyngeal squamous cell carcinoma (OPSCC), including tonsillar squamous cell carcinoma (TSCC), by the International Agency for Research against Cancer. Just before, in 2006, the Food and Drug Administration had approved Gardasil, the first vaccine against HPV16, 18, 6 and 11, for preventive vaccination women against cervical cancer. Concurrently, some Western...
Sat Nov 16, 2019 16:00
Abstract The relationship of evolution with diet and environment can provide insights into modern disease. Fossil evidence shows apes and early human ancestors were fruit‐eaters living in environments with strongly seasonal climates. Rapid cooling at the end of the middle Miocene (15‐12Ma: millions of years ago) increased seasonality in Africa and Europe, and ape survival may be linked with a mutation in uric acid metabolism. Climate stabilized in the later Miocene and Pliocene (12‐5Ma),...
Sat Nov 16, 2019 18:38
Abstract The majority of breast cancers are primarily hormone‐sensitive and could be managed by endocrine therapy, although therapy‐resistant or hormone‐refractory cancers need alternative treatments. Recently, increasing attention is being paid to RNA‐binding proteins (RBPs) in cancer pathophysiology. The precise role of RBPs in breast cancer, however, remains to be clarified. We here demonstrate that an RBP non‐POU domain containing octamer binding (NONO) plays a critical role in the pathophysiology...
Sat Nov 16, 2019 17:58
המהנדס אלכסנדר זרחין, חלוץ מחקר התפלת המים בישראל בטבת תשכ"ג, ינואר 1963, קיבל ראש הממשלה דוד בן־גוריון מכתב מאת המהנדס אלכסנדר זרחין, שהיה חלוץ מחקר התפלת המים בישראל הצעירה. במכתבו מזכיר זרחין הקצבה שאמור היה לקבל מהממשלה לקידום בניית מתקני התפלה שעליהם שקד. בן־גוריון השיב לזרחין קצרות שידבר על ההקצבה עם השרים המופקדים על כך, ואת יתר המכתב הקדיש לשאלה לשונית – ביקורת על השימוש בשורש תפ"ל במשמע הרחקת המלחים ממי הים. בן־גוריון מציין שתפל פירושו חסר טעם ולא חסר מלח, ולכן הוא מבכר את המילה "המתקה"...
Sun Nov 17, 2019 11:23
Publication date: Available online 16 November 2019Source: NeuroImageAuthor(s): Karl-Jürgen Bär, Stefanie Köhler, Feliberto de la Cruz, Andy Schumann, Florian D. Zepf, Gerd WagnerAbstractPrevious research on central nervous serotonin (5-HT) function provided evidence for a substantial involvement of 5-HT in the regulation of brain circuitries associated with cognitive and affective processing. The underlying neural networks comprise core subcortical/cortical regions such as amygdala and medial prefrontal...
Sun Nov 17, 2019 13:44
Publication date: Available online 16 November 2019Source: NeuroImageAuthor(s): Giampiero Bardella, Pierpaolo Pani, Emiliano Brunamonti, Franco Giarrocco, Stefano FerrainaAbstractHow neurons coordinate their collective activity for behavioural control is an open question in neuroscience. Several studies have progressively proven, on various scales, that the patterns of neural synchronization change accordingly with behavioural events. However, the topological features of the neural dynamics that...
Sun Nov 17, 2019 13:44
Publication date: Available online 16 November 2019Source: NeuroImageAuthor(s): Jordy Tasserie, Antoine Grigis, Lynn Uhrig, Morgan Dupont, Alexis Amadon, Béchir JarrayaAbstractNon-human primate functional MRI (fMRI) is a growing field in neuroscience. However, there is no standardized method for monkey fMRI data analysis, specifically for data preprocessing. The preprocessing of monkey fMRI data is challenged by several technical and experimental specificities of the monkey research such as artifacts...
Sun Nov 17, 2019 13:44
Publication date: Available online 16 November 2019Source: NeuroImageAuthor(s): Isha Dhingra, Sheng Zhang, Simon Zhornitsky, Thang Le, Wuyi Wang, Herta H. Chao, Ifat Levy, Chiang-Shan R. LiAbstractPrevious studies have suggested age-related differences in reward-directed behavior and cerebral processes in support of the age effects. However, it remains unclear how age may influence the processing of reward magnitude. Here, with 54 volunteers (22–74 years of age) participating in the Monetary Incentive...
Sun Nov 17, 2019 13:44
Publication date: Available online 16 November 2019Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): E. Budak, A. YanarateşResumenObjetivoEste trabajo analiza el papel de la PET/TC con 18F-FDG en la detección del tumor primario en pacientes con metástasis óseas de origen desconocido (MOOD).Material y métodosEste estudio retrospectivo consideró al análisis histopatológico o el seguimiento clínico como datos de referencia en el diagnóstico de tumores primarios y estos resultados...
Sun Nov 17, 2019 13:55
Publication date: Available online 16 November 2019Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): J.F. Jiménez-Bonilla, R. Quirce, M. De Arcocha-Torres, I. Martínez-Rodríguez, N. Martínez-Amador, I. Banzo
Sun Nov 17, 2019 13:55
Abstract Food allergies have become a significant heath burden as prevalence continues to rise, affecting 6‐13% of the global population. In the absence of drugs approved by regulatory agencies, the current standard of care remains avoidance of allergenic foods and management of acute allergic reactions with antihistamines and epinephrine auto‐injectors. Allergen immunotherapy has been shown to increase the threshold of reactivity in the majority of food‐allergic individuals. However, challenges...
Sat Nov 16, 2019 17:09
Abstract Clemens Peter Freiherr (= Baron) von Pirquet (Figure 1) was born in Hirschstetten near Vienna on 12 May 1847 into a patrician family originally from Liège. His father Peter Zeno was a member of parliament. His mother Flora Freiin (= Baroness) von Pereira‐Arnstein came from an assimilated Jewish banking family but had been brought up Catholic.
Sat Nov 16, 2019 17:24
Abstract Diffuse optical tomography (DOT) is an emerging imaging technique which uses light for diagnostic purposes in non‐invasive and non‐ionizing way. In this paper, we focus on DOT application to female breast screening, where the surface of the breast is illuminated by light sources and the outgoing light is collected on the surface. The comparison of measured light data with the equivalent field obtained from a relevant mathematical model yields the DOT inverse problem whose solution provides...
Sat Nov 16, 2019 12:18
Publication date: Available online 16 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Guang-Hui Shen, Ye Song, Ye Yao, Qing-Feng Sun, Bao Jing, Jia Wu, Shi-Yong Li, Si-Qi Liu, Hao-Cheng Li, Chao Yuan, Gao-Yan Liu, Jing-Bo Li, Xin-Yu Liu, Hai-Yang WangObjectiveThis study aimed to investigate the effect of long non-coding RNA (lncRNA) DLGAP1 antisense RNA 1 (DLGAP1-AS1) on vascular endothelial cell (VEC) injury via the phosphoinositide 3-kinase (PI3K)/Akt pathway...
Sun Nov 17, 2019 14:56
Publication date: Available online 16 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Thea Kreutzburg, Frederik Peters, Henrik C. Rieß, Sandra Hischke, Ursula Marschall, Levente Kriston, Helmut L'Hoest, Art Sedrakyan, Eike S. Debus, Christian-Alexander BehrendtObjectivesPatients suffering from peripheral arterial occlusive disease (PAOD) are a central target population for multidisciplinary vascular medicine. This study aimed to highlight trends in treatment patterns...
Sun Nov 17, 2019 14:56
Related ArticlesRole of Mechanistic Target of Rapamycin and Autophagy in Alcohol-Induced Adipose Atrophy and Liver Injury. Am J Pathol. 2019 Nov 13;: Authors: Li Y, Chao X, Wang S, Williams JA, Ni HM, Ding WX Abstract Chronic alcohol consumption induces adipose tissue atrophy. However, the mechanisms for how alcohol induces lipodystrophy and its impact on liver steatosis and injury are not fully elucidated. Autophagy is a highly conserved lysosomal degradation...
Sun Nov 17, 2019 15:26
Publication date: Available online 16 November 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Shaghayegh Omidvar, Zahra Jeddi, Afsaneh Doosti, Seyed Basir HashemiAbstractObjectivesThe coincidence of attention-deficit/hyperactivity disorder (ADHD) and hearing loss in the children has adverse effects in speech, cognition, communication and motor development. This can influence cochlear implant (CI) outcomes negatively. The aim of this study was to compare auditory, language,...
Sun Nov 17, 2019 15:28
Related ArticlesThe Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2019 Oct 25;11(11): Authors: Hermida-Prado F, Granda-Díaz R, Del-Río-Ibisate N, Villaronga MÁ, Allonca E, Garmendia I, Montuenga LM, Rodríguez R, Vallina A, Alvarez-Marcos C, Rodrigo JP, García-Pedrero JM Abstract Aberrant SRC expression and activation is frequently detected in multiple cancers, and hence,...
Sun Nov 17, 2019 15:31
Related ArticlesUtility of acoustic pharyngometry for screening of obstructive sleep apnea. Auris Nasus Larynx. 2019 Nov 12;: Authors: Kim BY, Cho JH, Kim DH, Kim SW, Kim SW, Kim BG, Park YJ Abstract OBJECTIVE: To determine whether combining acoustic pharyngometric parameters with cephalometric and clinical parameters could improve the predictive power for significant obstructive sleep apnea (OSA) in a Korean population. METHODS: A total of...
Sun Nov 17, 2019 15:31
Related ArticlesResection of inverted papilloma in nasal cavity with transseptal access and crossing multiple incisions minimizes bleeding and reveals the tumor pedicle. Auris Nasus Larynx. 2019 Nov 12;: Authors: Omura K, Nomura K, Aoki S, Hosokawa Y, Tanaka Y, Otori N, Kojima H Abstract OBJECTIVE: Sinonasal inverted papilloma can be resected endoscopically, but has a risk of recurrence. This risk can be minimized by identifying the pedicle of the tumor...
Sun Nov 17, 2019 15:31
Related ArticlesAcoustic Trauma Modulates Cochlear Blood Flow and Vasoactive Factors in a Rodent Model of Noise-Induced Hearing Loss. Int J Mol Sci. 2019 Oct 25;20(21): Authors: Shin SA, Lyu AR, Jeong SH, Kim TH, Park MJ, Park YH Abstract Noise exposure affects the organ of Corti and the lateral wall of the cochlea, including the stria vascularis and spiral ligament. Although the inner ear vasculature and spiral ligament fibrocytes in the lateral wall...
Sun Nov 17, 2019 15:33
Related ArticlesPediatric Thyroidectomy: NSQIP-P Analysis of Adverse Perioperative Outcomes. Ann Otol Rhinol Laryngol. 2019 Nov 15;:3489419889069 Authors: Patel VA, Khaku A, Carr MM Abstract BACKGROUND: This study identifies risk factors and 30-day adverse outcomes of pediatric patients undergoing thyroidectomy. METHODS: Retrospective analysis utilizing the American College of Surgeons National Surgical Quality Improvement-Pediatric Database...
Sun Nov 17, 2019 15:33
Related ArticlesUtility of Audiometry in the Evaluation of Patients Presenting with Dysphonia. Ann Otol Rhinol Laryngol. 2019 Nov 15;:3489419889373 Authors: Ross J, Valentino WL, Calder A, Bigly D, Othman S, McKinnon B, Sataloff RT Abstract OBJECTIVES: Hearing loss has been implicated in dysphonia secondary to voice misuse, although the data supporting this claim are scant. Determining the prevalence of hearing loss in patients with dysphonia and correlating...
Sun Nov 17, 2019 15:33
Related ArticlesLimited Evidence Suggests Metformin Might Be Beneficial to Reduce Head and Neck Cancer Risk and Increase Overall Survival, While Any Benefit With Antiinflammatory Drugs Is Inconsistent. J Evid Based Dent Pract. 2019 Sep;19(3):298-300 Authors: Veitz-Keenan A, Silvestre Calle TD, Bergamini M Abstract ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Protective effects of metformin, statins, and antiinflammatory drugs on head and neck cancer:...
Sun Nov 17, 2019 15:33
Related ArticlesEfficacy of lianhuaqingwen granules in the management of chronic rhinosinusitis without nasal polyps. Am J Otolaryngol. 2019 Oct 18;:102311 Authors: Lin L, Dai F, Ren G, Wei J, Chen Z, Tang X Abstract OBJECTIVES: Chronic rhinosinusitis (CRS) is a complicated disease with clinical symptoms that are impacted by the absence or presence of nasal polyps (CRSsNP or CRSwNP). Understanding of the different treatments of CRS is very significant...
Sun Nov 17, 2019 15:33
Related ArticlesUsefulness of ultrasound and fine needle aspiration cytology of major salivary gland lesions. Am J Otolaryngol. 2019 Sep 10;:102293 Authors: Yariv O, Popovtzer A, Wasserzug O, Neiderman NC, Halperin D, Lahav Y, Lahav G, Yehuda M Abstract PURPOSE: To assess the clinical value of ultrasound (US) and fine needle aspiration (FNA) of salivary gland lesions prior to surgery, for preoperative decision-making and long-term follow-up/outcome....
Sun Nov 17, 2019 15:33
Related ArticlesBone mineral density and serum 25-hydroxyvitamin D in subtypes of idiopathic benign paroxysmal positional vertigo. Am J Otolaryngol. 2019 Oct 17;:102313 Authors: Han K, Yun YM, Moon SG, Kim CH Abstract Although the etiology of benign paroxysmal positional vertigo (BPPV) is idiopathic in most cases, the association of osteoporosis or vitamin D deficiency with BPPV has attracted much interest recently. While it is generally accepted that...
Sun Nov 17, 2019 15:33
Related ArticlesThe effect of transcutaneous electrical nerve stimulation (TENS) on chronic subjective tinnitus. Am J Otolaryngol. 2019 Oct 29;:102326 Authors: Tutar B, Atar S, Berkiten G, Üstün O, Kumral TL, Uyar Y Abstract OBJECTIVES: Chronic Subjective Tinnitus is a very highly prevalent disorder worldwide. There is no definitive treatment. The aim of this study is to investigate the efficacy of transcutaneous electrical nerve stimulation (TENS) applied...
Sun Nov 17, 2019 15:33
Comparison of arytenoid vertical height discrepancy in normal versus patients with vocal cord palsy.
Related ArticlesComparison of arytenoid vertical height discrepancy in normal versus patients with vocal cord palsy. Am J Otolaryngol. 2019 Oct 24;:102323 Authors: Wong EH, Smith M, Tjahjono R, Stone DB, Sritharan N, Palme CE, Smith MC, Riffat F Abstract OBJECTIVE: Cadaveric experiments and more recently clinical data have demonstrated that patients with vertical height discrepancy between their arytenoids experience poorer voice outcomes in patients...
Sun Nov 17, 2019 15:33
Related ArticlesSubmental flap practice patterns and perceived outcomes: A survey of 212 AHNS surgeons. Am J Otolaryngol. 2019 Oct 30;:102291 Authors: Tang L, Day AT, Lee R, Gordin E, Emerick K, Patel UA, Deschler DG, Richmon JD Abstract OBJECTIVES: To describe American Head and Neck Society (AHNS) surgeon submental flap (SMF) practice patterns and to evaluate variables associated with SMF complications. METHODS: The design is a cross-sectional...
Sun Nov 17, 2019 15:33
Related ArticlesAn association between marijuana use and tinnitus. Am J Otolaryngol. 2019 Nov 12;:102314 Authors: Qian ZJ, Alyono JC Abstract OBJECTIVE: While some advocates have argued for marijuana as a treatment for tinnitus, the relationship between marijuana use and tinnitus is unknown. The objective of this study was to evaluate associations between marijuana use and the prevalence, severity, and rate of occurrence of tinnitus. STUDY DESIGN:...
Sun Nov 17, 2019 15:33
Related ArticlesLong-term treatment with clarithromycin and carbocisteine improves lung function in chronic cough patients with chronic rhinosinusitis. Am J Otolaryngol. 2019 Oct 17;:102315 Authors: Kariya S, Okano M, Higaki T, Makihara S, Tachibana T, Nishizaki K Abstract PURPOSE: Chronic cough is a common complaint. Because the pathophysiology of chronic cough is complicated, the management of chronic cough is challenging. To the best of our knowledge,...
Sun Nov 17, 2019 15:33
Related ArticlesImpact of perforation size and predictive factors for successful pediatric gelfoam myringoplasty. Am J Otolaryngol. 2019 Nov 12;:102317 Authors: Shay EO, Shah J, Smith B, Anne S Abstract OBJECTIVES: Rates of success with pediatric myringoplasty range from 35 to 95%. The objective of this study is to evaluate the impact of perforation size on successful closure of the tympanic membrane (TM) after gelfoam myringoplasty. We also aim to identify...
Sun Nov 17, 2019 15:33
Related ArticlesComplications of Palatal Pillar Implants: An analysis of the MAUDE database and literature review. Am J Otolaryngol. 2019 Oct 05;:102303 Authors: Povolotskiy R, Abraham ME, Leverant AB, Bresler A, Paskhover B Abstract PURPOSE: The Pillar Palatal Implant System is a minimally invasive procedure for the treatment of obstructive sleep apnea and snoring. Prior studies have examined the effectiveness of this procedure, however no prior study...
Sun Nov 17, 2019 15:33
Related ArticlesSocial determinants of health and survivorship in parotid cancer: An analysis of the National Cancer Database. Am J Otolaryngol. 2019 Oct 18;:102307 Authors: Stubbs VC, Rajasekaran K, Cannady SB, Newman JG, Ibrahim SA, Brant JA Abstract BACKGROUND: Given the rarity of parotid cancer, there is relatively few data published regarding outcomes. Utilizing the large sample population of the National Cancer Database (NCDB), we aim to examine...
Sun Nov 17, 2019 15:33
Related ArticlesFrench adaptation of the "Frenchay Dysarthria Assessment 2" speech intelligibility test. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Nov 12;: Authors: Ghio A, Giusti L, Blanc E, Pinto S Abstract OBJECTIVES: Speech intelligibility can be defined as "the degree to which a speaker's intended message is recovered by a listener". Loss of intelligibility is one of the most frequent complaints in patients suffering from speech disorder, impairing...
Sun Nov 17, 2019 15:33
Related ArticlesRadiotherapy of extranodal low-grade follicular and marginal zone lymphomas: long-term follow-up of 159 patients. Strahlenther Onkol. 2019 Nov 15;: Authors: Elsayad K, Reinartz G, Oertel M, Rehn S, Eismann J, Scobioala S, Berssenbrügge H, Eter N, Weishaupt C, Schmidt HH, Friedrichs B, Grünewald I, Hartmann W, Lenz G, Wardelmann E, Willich N, Eich HT Abstract OBJECTIVE: To evaluate clinical, histopathologic, and radiation (RT) dose parameters...
Sun Nov 17, 2019 15:33
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