Implicit Learning in the Developing Brain: An Exploration of ERP Indices for Developmental Disorders
Publication date: Available online 10 September 2019Source: Clinical NeurophysiologyAuthor(s): Tatsuya Daikoku
Wed Sep 11, 2019 12:54
Abstract The Th2 cytokines interleukin 4 (IL‐4) and IL‐13 and the heterodimeric IL‐4 receptor (IL‐4R) complexes that they interact with play a key role in the pathogenesis of allergic disorders. Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL‐4 receptor alpha chain (IL‐4Rα), common to both IL‐4R complexes: type 1 (IL‐4Rα/γc; IL‐4 specific) and type 2 (IL‐4Rα/IL‐13Rα1; IL‐4 and IL‐13 specific). In this review we detail the current state of knowledge of the different signaling...
Tue Sep 10, 2019 21:48
Iron is the most common trace mineral in the body. The effects of iatrogenic iron pill-induced gastritis (IPIG) at therapeutic levels are underreported and underappreciated in the paediatric population. Herein, we report a case of an 11-year-old boy presenting with increasing epigastric pain and refusing oral intake secondary to iron pill tablets. We report only the second confirmed case of a paediatric patient with IPIG in the peer-reviewed literature.
Wed Sep 11, 2019 11:05
Here, we report the case of a patient with renal allograft with full‐house immunofluorescence staining in the zero‐hour biopsy. Full‐house immunofluorescence staining is a well‐known characteristic of lupus nephritis. Previous studies have reported patients with full‐house immunofluorescence staining, but without other symptoms or serological findings; this condition is referred to as full‐house nephropathy. We identified only one case out of 2203 zero‐hour biopsies over 13 years. Zero‐hour biopsy...
Wed Sep 11, 2019 12:10
Cerebral arterial air embolism is a rare and unexpected complication of advanced esophageal cancer. The entry of air to systemic circulation is an esophago‐left atrial or pulmonary vein fistula formation. Herein, we report an autopsy case of a 64‐year‐old man. He was diagnosed esophageal cancer 2 years ago and underwent chemotherapy and concurrent chemoradiotherapy but the disease progressed, unfortunately. Then two metal stents were inserted into the middle thoracic esophagus as a palliation of...
Wed Sep 11, 2019 12:10
Abstract Minimally invasive mitral valve surgery is generally performed through a right minithoracotomy, in contrast to the traditional full median sternotomy approach. Minimally invasive mitral valve surgery is performed with increasing frequency and by reducing surgical trauma several observational studies suggest potential benefits with decreased bleeding and postoperative pain, reduced incidence of sternal wound infections, reduced length of hospital stay and shortened recovery period...
Tue Sep 10, 2019 13:34
Publication date: Available online 9 September 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Marie Pouzolles, Alice Machado, Mickaël Guilbaud, Magali Irla, Sarah Gailhac, Pierre Barennes, Daniela Cesana, Andrea Calabria, Fabrizio Benedicenti, Arnauld Sergé, Indu Raman, Quan-Zhen Li, Eugenio Montini, David Klatzmann, Oumeya Adjali, Naomi Taylor, Valérie S. ZimmermannAbstractBackgroundPatients with T cell immunodeficiencies are generally treated by allogeneic hematopoietic stem cell...
Wed Sep 11, 2019 13:13
Publication date: Available online 9 September 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Xingnan Li, Annette T. Hastie, Michael C. Peters, Gregory A. Hawkins, Wanda Phipatanakul, Huashi Li, Wendy C. Moore, William W. Busse, Mario Castro, Serpil C. Erzurum, Benjamin Gaston, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Sally E. Wenzel, Deborah A. Meyers, John V. Fahy, Eugene R. Bleecker, NHLBI Severe Asthma Research Program (SARP) Networks
Wed Sep 11, 2019 13:13
Publication date: Available online 10 September 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Camila Soares Lopes, Suellen de Azevedo Moreira, Giovanni Antônio Nícoli, Iago Ramirez, Naiana Viana ViolaAbstractThis article describes the use of Photodynamic Therapy (PDT) during the endodontic treatment of teeth with periapical lesion. Patients presented tooth 35 with diagnostic hypotheses of Periapical Cyst or Granuloma. The Crown-Down preparation was performed with the HyFlex CM system....
Wed Sep 11, 2019 13:23
Abstract The purpose of this study is to assess the effect of autoclave sterilization on the cyclic fatigue and torsional fracture resistance of ProTaper Universal (PTU), K3XF, HyFlex EDM (EDM), and TF adaptive (TFA). Sixty instruments from each file type were divided into two categories for cyclic fatigue group (CGr) and torsional fracture group (TGr). CGr and TGr were divided into three subgroups, respectively, consisting of ten instruments from each file type. Cyclic fatigue...
Wed Sep 11, 2019 03:00
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Qianqian Zhang, Hong Sun, Shougang Zhuang, Na Liu, Xiaowei Bao, Xiandong Liu, Huijuan Ren, Diyu Lv, Zhe Li, Jianwen Bai, Xiaohui Zhou, Lunxian TangAbstractThe function of histone methyltransferase enhancer of zeste homolog 2 (EZH2) in sepsis remains unknown. We reported here that the expression of EZH2 and H3K27me3 was significantly upregulated in the circulation of septic patients, whereas patients who survived...
Wed Sep 11, 2019 13:36
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Shuang-feng Zi, Jing-hui Li, Lei Liu, Chao Deng, Xue Ao, Dan-dan Chen, Sheng-zan WuAbstractBackgroundUncontrolled inflammatory responses exacerbate the pathogenesis of septic acute liver injury (ALI), posing a lethal threat to the host. Dexmedetomidine (DEX) has been reported to possess protective properties in inflammatory conditions. This study aimed to investigate whether DEX pretreatment exhibits hepatoprotection...
Wed Sep 11, 2019 13:36
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Lei Wang, Jianying Xu, Hu Liu, Jie Li, Hailong HaoAbstractBronchial asthma is the most common chronic respiratory disease. Chronic airway inflammation, airflow restriction and airway hyper-responsiveness are its main manifestations. In recent decades, the prevalence and mortality of asthma have been increasing all over the world, which seriously threatens public health. Research suggests that air pollution...
Wed Sep 11, 2019 13:36
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Guang Chen, Yun-ting Du, Jian-hua Liu, Ying Li, Li Zheng, Xiao-song Qin, Ya-ming CaoAbstractVitamin A (VA) is an anti-inflammatory agent that is important in modulating and balancing the immune system. The present study aimed to investigate the immunoregulatory effects of vitamin A supplement (VAS) in C57BL/6J mice infected with Plasmodium yoelii 17XL (P.y17XL) or Plasmodium berghei ANKA (P.bANKA). Following...
Wed Sep 11, 2019 13:36
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Wen-Jun Qiu, Ming-Ze Xu, Xiao-dong Zhu, Yun-Han JiAbstractOsteoarthritis (OA) is a common disease of the articular cartilage, and inflammatory response and articular cartilage degradation have been implicated in the pathogenesis of OA. In recent years, microRNAs (miRNAs) have been potentially involved in the pathogenesis of OA. However, little is known about the role of miRNAs in the inflammatory response...
Wed Sep 11, 2019 13:36
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Pengyu Ma, Delu Che, Tingting Zhao, Yongjing Zhang, Chaomei Li, Hongli An, Tao Zhang, Huaizhen HeAbstractMast cells (MCs) play critical roles in allergic reactions and modulating the activation of MCs could be an effective strategy to treat allergic diseases, which cause a rapidly increasing threat to the public health. Herein, we described that Magnolin, a major component from Flos magnoliae could inhibit...
Wed Sep 11, 2019 13:36
Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Nobuhiro Fujiyama, Shigeru Satoh, Mitsuru Saito, Kazuyuki Numakura, Takamitsu Inoue, Ryohei Yamamoto, Takuro Saito, Taketoshi Nara, Sohei Kanda, Shintaro Narita, Hideaki Kagaya, Masatomo Miura, Tomonori HabuchiAbstractThe association between immunosuppressive therapy or cytomegalovirus (CMV) infection and detection of de novo donor-specific antibody (dnDSA) at 1 year after transplantation was evaluated. The...
Wed Sep 11, 2019 13:36
Publication date: Available online 11 September 2019Source: Journal of the American College of SurgeonsAuthor(s): Joost Huiskens, Karen Bolhuis, Marc RW. Engelbrecht, Koert P. De Jong, Geert Kazemier, Mike SL. Liem, Cornelis Verhoef, Johannes HW. de Wilt, Cornelis JA. Punt, Thomas M. van Gulik, Dutch Colorectal Cancer GroupAbstractIntroductionDecision making on optimal treatment strategy in patients with initially unresectable colorectal cancer liver metastases (CRLM) remains complex because uniform...
Wed Sep 11, 2019 13:39
Abstract This study determined individual optimal amrubicin doses for Japanese patients with lung cancer after platinum‐based treatment. We conducted population pharmacokinetic and pharmacodynamic modeling incorporating gene polymorphisms of metabolizing enzymes and transporters. Fifty patients with lung cancer, who were administered 35–40 mg/m2 amrubicin on days 1–3 every 3–4 weeks, were enrolled. Mechanism‐based modeling described relationships between the pharmacokinetics of amrubicin and absolute...
Tue Sep 10, 2019 20:54
Abstract Cancer stem cells (CSCs) are a subpopulation of tumor cells with properties of high tumorigenicity and drug resistance, which lead to recurrence and poor prognosis. Although a better understanding of CSCs is essential for developing cancer therapies, the scarcity of the CSC population has hindered such analyses. The aim of this study was to elucidate whether the E‐cadherin‐Fc chimera protein (E‐cad‐Fc) would enhance cancer stem‐like properties because studies show that soluble E‐cadherin...
Tue Sep 10, 2019 20:54
Publication date: Available online 11 September 2019Source: Medical HypothesesAuthor(s): M. Simka, J. Czaja, D. KowalczykAbstractRecent research has revealed that patients with neurodegenerative disease sleep longer in the supine position, while healthy controls prefer sleeping in the lateral decubitus position. Thus, sleeping in the lateral position seems to be protective against neurodegeneration. It has also been suggested that a protective role of this body position could be associated with better...
Wed Sep 11, 2019 13:42
Abstract Purpose To examine the association between catastrophizing and pain intensity with acute herpes zoster, and the association of treatment-related early changes in depressive symptoms, anxiety, and catastrophizing with postherpetic neuralgia (PHN) development, independent of acute pain intensity. Methods We analyzed 44 outpatient participants with...
Wed Sep 11, 2019 03:00
ABSTRACT Genome‐scale high‐throughput sequencing enables the detection of unprecedented numbers of sequence variants. Variant filtering and interpretation are facilitated by mutation databases, in silico tools, and population‐based reference datasets such as ExAC/gnomAD, while variants are classified using the ACMG/AMP guidelines. These methods, however, pose clinically relevant challenges. We queried the gnomAD dataset for (likely) pathogenic variants in genes causing autosomal‐dominant...
Wed Sep 11, 2019 14:30
ABSTRACT A variety of different signaling pathways are necessary for development and maintenance of the human auditory system. Normal hearing allows for the detection of soft sounds within the frequency range of 20 to 20 000 Hz, but more importantly to perceive the human voice frequency band of 250 to 6000 Hz. Loss of hearing is common, and is a clinically heterogeneous disorder that can be caused by environmental factors such as exposure to loud noise, infections and ototoxic drugs. In...
Wed Sep 11, 2019 14:30
Abstract Cetaceans possess brains that rank among the largest to have ever evolved, either in terms of absolute mass or relative to body size. Cetaceans have evolved these huge brains under relatively unique environmental conditions, making them a fascinating case study to investigate the constraints and selection pressures that shape how brains evolve. Indeed, cetaceans have some unusual neuroanatomical features, including a thin but highly folded cerebrum with low cortical neuron density, as well...
Tue Sep 10, 2019 21:39
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Ali Jahanban-Esfahlan, Leila Roufegarinejad, Rana Jahanban-Esfahlan, Mahnaz Tabibiazar, Ryszard AmarowiczAbstractRecently, enormous attention has been focused on the development of protein-molecularly imprinted polymers (MIPs). In this sense, bovine serum albumin (BSA) is well regarded as a favorite template in various MIPs-based biochemical/analytical assays mainly due to its low price, easy availability, and high structural...
Wed Sep 11, 2019 14:47
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Xiaobo Wang, Xiaoyan Ma, Jinghan Wen, Zhirong Geng, Zhilin WangAbstractDetection of glutathione in human serum is of great importance for clinical diagnosis of various diseases, such as AIDS, diabetes mellitus, Alzheimer disease and cancer. In this work, a new water-soluble bismacrocyclic polyamine-derived compound, namely L, which contains two molecules of 4-nitro-1,2,3-benzoxa-diazole as the fluorophores, was designed and prepared....
Wed Sep 11, 2019 14:47
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Rana Chehab, Bruno Coulomb, Jean-Luc Boudenne, Fabien Robert-PeillardAbstractInorganic chloramines are disinfection by-products resulting from the unwanted reaction between chlorine used as disinfectant in swimming pools and nitrogenous compounds brought by bathers. This parameter (total chloramines or combined chlorine) is currently measured on site by a colorimetric method that does not allow to measure only inorganic chloramines....
Wed Sep 11, 2019 14:47
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Mahirah Taib, Ling Ling Tan, Nurul Huda Abd Karim, Goh Choo Ta, Lee Yook Heng, Bahariah KhalidAbstractAn optical aptasensor-based sensing platform for rapid insulin detection was fabricated. Aminated porous silica microparticles (PSiMPs) were synthesized via a facile mini-emulsion method to provide large surface area for covalent immobilization of insulin-binding DNA aptamer (IGA3) by glutaraldehyde cross-linking protocol. A Nickel-salphen...
Wed Sep 11, 2019 14:47
Revised staging system for malignant lymphoma based on the Lugano classification. Jpn J Clin Oncol. 2019 Aug 28;: Authors: Munakata W, Terauchi T, Maruyama D, Nagai H Abstract The Lugano classification was published in 2014 to form the basis for revising the recommendations regarding anatomic staging and evaluation of disease before and after therapy. This staging system was adopted by the eighth edition of the Cancer Staging Manual of the American Joint...
Wed Sep 11, 2019 14:50
Long-term outcome, relapse patterns, and toxicity after radiotherapy for orbital mucosa-associated lymphoid tissue lymphoma: implications for radiotherapy optimization. Jpn J Clin Oncol. 2019 Jul 01;49(7):664-670 Authors: Lee J, Yoon JS, Kim JS, Koom WS, Cho J, Suh CO Abstract OBJECTIVES: Although mucosa-associated lymphoid tissue lymphoma (MALToma) is sensitive to radiation therapy (RT), the optimal RT dose and treatment volumes have not been established....
Wed Sep 11, 2019 14:50
Use of intensity-modulated radiation therapy for nasopharyngeal cancer in Japan: analysis using a national database. Jpn J Clin Oncol. 2019 Jul 01;49(7):639-645 Authors: Rikitake R, Tsukada Y, Ando M, Yoshida M, Iwamoto M, Yamasoba T, Higashi T Abstract BACKGROUND: Intensity-modulated radiation therapy (IMRT) yields better outcomes and fewer toxicities for radiation therapy (RT) of head and neck cancers (HNCs), including nasopharyngeal cancer (NPC)....
Wed Sep 11, 2019 14:50
132 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/09/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Sep 11, 2019 14:50
Alendronate effect in esophagus, stomach and liver: an animal based pathological study. Histol Histopathol. 2019 Sep 10;:18161 Authors: Papamitsou T, Sotiriou S, Papakoulas A, Toskas A, Kamperis D, Karachrysafi S, Dietrich EM, Lialiaris S, Sioga A Abstract Bisphosphonates are commonly used in clinical practice. Their effectiveness is indisputable, however their adverse effects, especially in the GI tract, are still controversial. In our report, we demonstrate...
Wed Sep 11, 2019 14:51
Related ArticlesDifferent Pharmacological Properties of GLUT9a and GLUT9b: Potential Implications in Preeclampsia. Cell Physiol Biochem. 2019;53(3):508-517 Authors: Lüscher BP, Surbek DV, Clémençon B, Huang X, Albrecht C, Marini C, Hediger MA, Baumann MU Abstract BACKGROUND/AIMS: Glucose transporter 9 (GLUT9/SLC2A9) is the major regulator of uric acid homeostasis in humans. Hyperuricemia due to impaired regulation by GLUT9 in pregnancy is closely associated...
Wed Sep 11, 2019 14:51
Related ArticlesFTY720P Upregulates the Na+/K+ ATPase in HepG2 Cells by Activating S1PR3 and Inducing PGE2 Release. Cell Physiol Biochem. 2019;53(3):518-531 Authors: Chakkour M, Kreydiyyeh S Abstract BACKGROUND/AIMS: Liver regeneration is induced by S1P and accompanied with an increase in hepatic Na+/K+ ATPase activity, suggesting a potential modulatory role of the sphingolipid on the ATPase activity. The ability of S1P to alter the ATPase activity was...
Wed Sep 11, 2019 14:51
Related Articles[Pitfalls in the statistical world]. HNO. 2019 Sep 09;: Authors: Kiese-Himmel C, Plontke SK Abstract Mistakes in the acquisition, evaluation, analysis and reporting of data often occur because there is a lack of awareness of the methodological problem. They can have far-reaching consequences for the reception of results of scientific primary studies and therefore for the clinical practice and healthcare. This article aims at raising awareness...
Wed Sep 11, 2019 14:51
Related ArticlesDaytime Versus Night-Time Emergency Abdominal Operations: Perspective from a Low-Middle-Income Country. World J Surg. 2019 Sep 09;: Authors: Ndegbu CU, Olasehinde O, Sharma A, Arowolo OA, Adisa AO, Alatise OI, Adesunkanmi ARK, Lawal OO Abstract BACKGROUND: Emergency abdominal operations carry significant risk of mortality and morbidity. The time of the day when such operations are performed has been suggested as a predictor of outcome....
Wed Sep 11, 2019 14:53
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