Publication date: Available online 23 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Monica M. Diaz, Sarah F. WesleyAbstractBackgroundLyme disease is a common vector-borne illness in the U.S. caused by Borrelia species spirochetes. Neuroborreliosis has variable presentations, rarely manifesting as meningoradiculitis or "Bannwarth Syndrome", characterized by painful radiculopathy, neuropathy, varying degrees of motor weakness, peripheral facial nerve palsy andcerebrospinal fluid...
Tue Sep 24, 2019 13:55
Publication date: Available online 23 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Xiaomeng Wang, Xueping Zheng, Song Hu, Ang Xing, Zixuan Wang, Yan Song, Jingjiao Chen, Sijia Tian, Yongjun Mao, Xiaosa ChiAbstractThe efficacy of perioperative seizure prophylaxis in seizure-naïve glioma patients is still controversial. Thus we conducted this meta-analysis to assess the effectiveness of perioperative prophylactic antiepileptic drugs (AEDs) on postoperative seizures in seizure-naïve...
Tue Sep 24, 2019 13:55
Related ArticlesRedirecting the revolution: new developments in drug development for psychiatry. Expert Opin Drug Discov. 2019 Sep 23;:1-7 Authors: Brady LS, Potter WZ, Gordon JA PMID: 31545131 [PubMed - as supplied by publisher]
Tue Sep 24, 2019 15:53
Related ArticlesTreatment patterns and overall survival among patients with unresectable, stage III non-small-cell lung cancer. Future Oncol. 2019 Sep 23;: Authors: Bobbili P, Ryan K, Duh MS, Dua A, Fernandes AW, Pavilack M, Gomez JE Abstract Aim: To analyze treatment patterns and overall survival (OS) across time (2009-2014) among patients with unresected, stage III non-small-cell lung cancer (NSCLC). Patients & methods: Stage III NSCLC patients...
Tue Sep 24, 2019 15:57
Synergistic effect of the pro-apoptosis peptide kla-TAT and the cationic anticancer peptide HPRP-A1.
Related ArticlesSynergistic effect of the pro-apoptosis peptide kla-TAT and the cationic anticancer peptide HPRP-A1. Apoptosis. 2018 02;23(2):132-142 Authors: Hu C, Chen X, Huang Y, Chen Y Abstract In this study, a peptide-peptide co-administration therapy between hybrid peptide kla-TAT and cationic anticancer peptide HPRP-A1 was designed to increase the anticancer activity of the combination peptides through synergistic effect. kla is a pro-apoptotic...
Tue Sep 24, 2019 13:57
Related ArticlesEpirubicin induces apoptosis in osteoblasts through death-receptor and mitochondrial pathways. Apoptosis. 2018 04;23(3-4):226-236 Authors: Huang TC, Chiu PR, Chang WT, Hsieh BS, Huang YC, Cheng HL, Huang LW, Hu YC, Chang KL Abstract Epirubicin is an anthracycline and is widely used in tumor treatment, but has toxic and undesirable side effects on wide range of cells and hematopoietic stem cells (HSC). Osteoblasts play important roles...
Tue Sep 24, 2019 13:57
Related ArticlesRationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma. Cancer. 2018 10 01;124(19):3819-3829 Authors: Wisdom AJ, Mowery YM, Riedel RF, Kirsch DG Abstract Soft tissue sarcomas (STS) are heterogeneous, mesenchymal malignancies with variable biologic behavior. The primary management for localized STS is surgical resection, which may be combined with neoadjuvant or adjuvant radiation therapy to increase the...
Tue Sep 24, 2019 13:57
Related ArticlesCdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism. J Cell Biol. 2018 10 01;217(10):3446-3463 Authors: Agarwal S, Smith KP, Zhou Y, Suzuki A, McKenney RJ, Varma D Abstract Robust kinetochore-microtubule (kMT) attachment is critical for accurate chromosome segregation. G2/M-specific depletion of human Cdt1 that localizes to kinetochores in an Ndc80 complex-dependent manner leads to abnormal...
Tue Sep 24, 2019 13:57
Related ArticlesHoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes. Blood Adv. 2018 11 27;2(22):3137-3148 Authors: Zhong X, Prinz A, Steger J, Garcia-Cuellar MP, Radsak M, Bentaher A, Slany RK Abstract Ectopic expression of the oncogenic transcription factor HoxA9 is a major cause of acute myeloid leukemia (AML). Here, we demonstrate that HoxA9 is a specific substrate of granule...
Tue Sep 24, 2019 13:57
Related ArticlesSystemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review. JAMA. 2019 08 27;322(8):764-774 Authors: Arbour KC, Riely GJ Abstract Importance: Non-small cell lung cancer remains the leading cause of cancer death in the United States. Until the last decade, the 5-year overall survival rate for patients with metastatic non-small cell lung cancer was less than 5%. Improved understanding of the biology of lung...
Tue Sep 24, 2019 13:57
Related ArticlesDiscovery of N-(2-Aminophenyl)-4-(bis(2-chloroethyl)amino)Benzamide as a Potent Histone Deacetylase Inhibitor. Front Pharmacol. 2019;10:957 Authors: Zhang L, Li X, Chen Y, Wan M, Jiang Q, Zhang L, Chou CJ, Song W, Zhang L Abstract Inhibition of histone deacetylases (HDACs) has been an important emerging therapy for the treatment of multiple cancers. However, the application of HDAC inhibitors is restricted by the limited potency against...
Tue Sep 24, 2019 13:57
Related ArticlesAntiproliferative Effect of Gaillardin from Inula oculus-christi in Human Leukemic Cells. Nutr Cancer. 2019 Sep 23;:1-14 Authors: Karami A, Hamzeloo-Moghadam M, Yami A, Barzegar M, Mashati P, Gharehbaghian A Abstract Gaillardin (GLN) is a sesquiterpene lactone isolated from the chloroform extract of Inula oculus-christi L. This natural compound has shown cytotoxicity in various cancerous cell line. However, its effect on leukemic cells...
Tue Sep 24, 2019 14:58
Related ArticlesOsteopontin promotes rat hepatocyte proliferation both in vitro and in vivo. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3745-3757 Authors: Wang G, Chu P, Chen M, Cheng L, Zhao C, Chen S, Li X, Yang G, Chang C Abstract Aim: This study aimed to examine the effects of osteopontin (OPN) on hepatocyte growth and liver regeneration (LR). Methods: A recombinant lentivirus expressing OPN and OPN-siRNAs were used to treat BRL-3A cells, while...
Tue Sep 24, 2019 14:58
Related ArticlesGanoderiol F purified from Ganoderma leucocontextum retards cell cycle progression by inhibiting CDK4/CDK6. Cell Cycle. 2019 Sep 22;:1-14 Authors: Li X, Xie Y, Peng J, Hu H, Wu Q, Yang BB Abstract This study was designed to purify molecules possess anti-cancer cell activity from the fruit body of Ganoderma leucocontextum. Bio-activity-guided purification and chromatographic separation of Ganoderma leucocontextum extract led to the enrichment...
Tue Sep 24, 2019 14:58
Related ArticlesNaked mole rats activate neuroprotective proteins during hypoxia. J Exp Zool A Ecol Integr Physiol. 2019 Sep 23;: Authors: Hawkins LJ, Hadj-Moussa H, Nguyen VC, Pamenter ME, Storey KB Abstract Naked mole rats are a long-lived animal model that age much like humans, but that can also withstand oxidative damage, cancer, neurodegenerative diseases, and severe hypoxic conditions, which is of particular interest to this study. The conditions...
Tue Sep 24, 2019 14:58
Related ArticlesExtra Virgin Olive Oil Minor Compounds Modulate Mitogenic Action of Oleic Acid on Colon Cancer Cell Line. J Agric Food Chem. 2019 Sep 23;: Authors: Storniolo CE, Martinez-Hovelman N, Martinez-Huelamo M, Lamuela-Raventós RM, Moreno JJ Abstract Experimental and clinical findings suggest that olive oil have a protective effect, whereas oleic acid consumption induces colorectal cancer (CRC). Considering this apparent contradiction, and that...
Tue Sep 24, 2019 14:58
Related ArticlesRNA sequencing analysis of the CAL-27 cell response to over-expressed ZNF750 gene revealed an extensive regulation on cell cycle. Biomed Pharmacother. 2019 Oct;118:109377 Authors: Liu X, Yang Y, Xu C, Yang H, Chen S, Chen H Abstract BACKGROUND: Zinc-finger protein 750 (ZNF750) is a potential tumor suppressor in oral squamous cell carcinoma (OSCC). However, the molecular mechanisms underlying its anti-tumor effect remain elusive in OSCC....
Tue Sep 24, 2019 14:58
Related ArticlesA natural small molecule induces megakaryocytic differentiation and suppresses leukemogenesis through activation of PKCδ/ERK1/2 signaling pathway in erythroleukemia cells. Biomed Pharmacother. 2019 Oct;118:109265 Authors: Yang J, Qiu J, Hu Y, Zhang Y, Chen L, Long Q, Chen J, Song J, Rao Q, Li Y, Gu W, Hao X Abstract Kaempferol-3-O-rhamnoside (KOR) has multiple potency involved in anti-cancer, anti-inflammatory and antibacterial actions....
Tue Sep 24, 2019 14:58
Related ArticlesDescending-SHIP2-mediated radiosensitivity enhancement through PI3K/Akt signaling pathway in laryngeal squamous cell carcinoma. Biomed Pharmacother. 2019 Oct;118:109392 Authors: Tang T, Xiao ZY, Shan G, Lei HB Abstract Laryngeal squamous cell carcinoma (LSCC) is the major type of laryngeal carcinoma. SHIP2 plays a critical role in malignant tumors and is associated with activation of PI3K/Akt signaling pathway. Here, we aimed to explore...
Tue Sep 24, 2019 14:58
Related ArticlesCUDC‑907 reverses pathological phenotype of keloid fibroblasts in vitro and in vivo via dual inhibition of PI3K/Akt/mTOR signaling and HDAC2. Int J Mol Med. 2019 Sep 23;: Authors: Tu T, Huang J, Lin M, Gao Z, Wu X, Zhang W, Zhou G, Wang W, Liu W Abstract Keloids are benign skin tumors with a high recurrence rate following surgical excision. Abnormal intracellular signaling is one of the key mechanisms involved in its pathogenesis. Over‑activated...
Tue Sep 24, 2019 14:58
Related ArticlesDeficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2. Mol Med Rep. 2019 Sep 10;: Authors: Sun Z, Lu J, Wu M, Li M, Bai L, Shi Z, Hao L, Wu Y Abstract Proper spindle formation and accurate chromosome segregation are essential for ensuring mitotic fidelity. Phosphatase and tensin homolog (PTEN) is a multifunctional protein, which is able to maintain the stability of the genome and chromosomes. The present...
Tue Sep 24, 2019 14:58
Related ArticlesMicroRNA‑20a negatively regulates the growth and osteoclastogenesis of THP‑1 cells by downregulating PPARγ. Mol Med Rep. 2019 Sep 12;: Authors: Wang H, Shen Y Abstract The present study aimed to explore the mechanisms through which microRNA (miR)‑20a may be involved in the differentiation of THP‑1 human acute monocytic leukemia cells into osteoclasts. THP‑1 cells were differentiated into macrophages (osteoclast precursors) and subsequently...
Tue Sep 24, 2019 14:58
Related ArticlesER-mediated anti-tumor effects of shikonin on breast cancer. Eur J Pharmacol. 2019 Sep 20;:172667 Authors: Yang Y, Gao W, Tao S, Wang Y, Niu J, Zhao P, Rao C, Yang L Abstract Estrogen receptor (ER) is expressed in most Breast cancer (BC) patients. G protein-coupled estrogen receptor (GPER), which is a membrane-bound estrogen receptor, is associated with the tumor development and progression in BC. Shikonin (SK) is a natural compound that...
Tue Sep 24, 2019 14:58
Abstract The 95th KoreAnesthesia Meeting was held successfully over 3 days from November 8 to 10, 2018 at Seoul Dragon-City Hotelplex, featuring 62 overseas speakers and 2960 attendees from 26 countries. KoreAnesthesia is the largest annual event hosted by the Korean Society of Anesthesiologists (KSA). The KSA hopes that many members of the Japanese Society of Anesthesiologists and readers of the Journal of Anesthesia will join us at the forthcoming KoreAnesthesia 2019 from October...
Tue Sep 24, 2019 03:00
Abstract Purpose This study aimed to assess the impact of intensivist coverage on the incidence of acute kidney injury (AKI) and ventilator time among patients postoperatively admitted to the intensive care unit (ICU). Methods Adult patients postoperatively admitted to the ICU between January 2012 and December 2017 were retrospectively enrolled. The incidence...
Tue Sep 24, 2019 03:00
Related ArticlesDoes Insurance Status Impact Delivery of Care with Upper Airway Stimulation for OSA? Ann Otol Rhinol Laryngol. 2019 Sep 22;:3489419878454 Authors: Patel J, Topf MC, Huntley C, Boon M Abstract OBJECTIVE: To understand differences in patient demographics, insurance-related treatment delays, and average waiting times for Medicare and private insurance patients undergoing upper airway stimulation (UAS) for treatment of obstructive sleep apnea...
Tue Sep 24, 2019 16:03
Mon Sep 23, 2019 18:43
Abstract Background Abacavir is associated with hypersensitivity reactions in individuals positive for the HLA‐B*57:01 allele. The drug binds within the peptide‐binding groove of HLA‐B*57:01 altering peptides displayed on the cell surface. Presentation of these HLA‐abacavir‐peptide complexes to T‐cells is hypothesised to trigger a CD8+ T‐cell response underpinning the hypersensitivity. Thus, the aim of this study was to explore the relationship between the structure of abacavir with HLA‐B*57:01...
Tue Sep 24, 2019 14:06
56 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/09/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 24, 2019 14:10
Related ArticlesHuman Domain Antibodies to Conserved Epitopes on HER2 Potently Inhibit Growth of HER2-Overexpressing Human Breast Cancer Cells In Vitro. Antibodies (Basel). 2019 Mar 18;8(1): Authors: Wang H, Wang Y, Xiao Z, Li W, Dimitrov DS, Chen W Abstract The FDA approval of two anti-HER2 monoclonal antibodies, trastuzumab and pertuzumab, and an antibody-drug conjugate, trastuzumab emtansine, has transformed clinical practice for HER2-positive cancers....
Tue Sep 24, 2019 14:12
Publication date: Available online 24 September 2019Source: Medical Image AnalysisAuthor(s): R. Agier, S. Valette, R. Kéchichian, L. Fanton, R. ProstAbstractWe present a novel algorithm for Fast Registration Of image Groups (FROG), applied to large 3D image groups. Our approach extracts 3D SURF keypoints from images, computes matched pairs of keypoints and registers the group by minimizing pair distances in a hubless way i.e. without computing any central mean image. Using keypoints significantly...
Tue Sep 24, 2019 14:12
113 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2019/09/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 24, 2019 13:16
113 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2019/09/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 24, 2019 14:15
Publication date: Available online 23 September 2019Source: Médecine & DroitAuthor(s): Paul Véron, Marie BaudelRésuméAlors que le Conseil d’État aune nouvelle fois confirmé la légalité de la décision médicale d’arrêt des traitements de Vincent Lambert, la Cour de cassation a jugé que l’État français n’est pas tenu de suspendre l’exécution de ladite décision dans l’attente que le Comité des droits pour les personnes handicapées, institution onusienne, rende son avis. La Haute juridiction ne se...
Tue Sep 24, 2019 14:15
Condition: LaryngectomyInterventions: Device: Reinforced prosthesis; Device: Standard prosthesisSponsor: Nantes University HospitalNot yet recruiting
Tue Sep 24, 2019 14:18
Related ArticlesCalcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway. Br J Pharmacol. 2018 11;175(21):4083-4094 Authors: Hannan FM, Olesen MK, Thakker RV Abstract The calcium-sensing receptor (CaS receptor) plays a pivotal role in extracellular calcium homeostasis, and germline loss-of-function and gain-of-function mutations cause familial hypocalciuric hypercalcaemia (FHH) and autosomal dominant...
Tue Sep 24, 2019 14:20
Related ArticlesTHAM administration reduces pulmonary carbon dioxide elimination in hypercapnia - an experimental porcine study. Acta Anaesthesiol Scand. 2018 07;62(6):820-828 Authors: Höstman S, Kawati R, Perchiazzi G, Larsson A Abstract BACKGROUND: In a previous study, we found a rebound of arterial carbon dioxide tension (PaCO2 ) after stopping THAM buffer administration. We hypothesized that this was due to reduced pulmonary CO2 elimination during...
Tue Sep 24, 2019 14:20
Stereotact Funct Neurosurg
Tue Sep 24, 2019 12:31
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