Neprilysin Inhibition in Heart Failure, Comparative Effectiveness of Pelvic Organ Prolapse and Urinary Incontinence Surgery, 2019 Adult Immunization Update, and more

ORIGINAL INVESTIGATION

Effect of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy With Uterosacral Ligament Suspension on Treatment Failure in Women With Uterovaginal Prolapse: A Randomized Clinical Trial

Charles W. Nager, MD; Anthony G. Visco, MD; Holly E. Richter, PhD, MD; et al.

Earn CME credit

Editorial: Pelvic Organ Prolapse: Reconsidering Treatment, Innovation, and Failure; Cynthia A. Brincat, MD, PhD

Effect of Behavioral and Pelvic Floor Muscle Therapy Combined With Surgery vs Surgery Alone on Incontinence Symptoms Among Women With Mixed Urinary Incontinence: The ESTEEM Randomized Clinical Trial

Vivian W. Sung, MD, MPH; Diane Borello-France, PT, PhD; Diane K. Newman, DNP; et al.

Earn CME credit

Editorial: Evidence-Based Treatment for Mixed Urinary Incontinence; Ingrid E. Nygaard, MD, MS

Effect of Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial

Akshay S. Desai, MD, MPH; Scott D. Solomon, MD; Amil M. Shah, MD; et al.

Earn CME credit

Clinical Review Audio: Management of Heart Failure in 2019-2020, Part 1

Editorial: Angiotensin Receptor–Neprilysin Inhibition (ARNI) Therapy and Reverse Remodeling in Heart Failure With Reduced Ejection Fraction; Mark H. Drazner, MD, MSc

Association of Change in N-Terminal Pro–B-Type Natriuretic Peptide Following Initiation of Sacubitril-Valsartan Treatment With Cardiac Structure and Function in Patients With Heart Failure With Reduced Ejection Fraction

James L. Januzzi Jr, MD; Margaret F. Prescott, PhD; Javed Butler, MD, MPH, MBA; et al.

Clinical Review Audio: Management of Heart Failure in 2019-2020, Part 2

Editorial: Angiotensin Receptor–Neprilysin Inhibition (ARNI) Therapy and Reverse Remodeling in Heart Failure With Reduced Ejection Fraction; Mark H. Drazner, MD, MSc

RESEARCH LETTER

Preventive Services Offered in Executive Physicals at Top-Ranked Hospitals

Deborah Korenstein, MD; Maha Mamoor, MS; Peter B. Bach, MD, MAPP

VIEWPOINT

Screening for Social Determinants of Health: The Known and Unknown

Karina W. Davidson, PhD, MASc; Thomas McGinn, MD, MPH

Audio Interview: Screening for Social Determinants of Health

Psychiatric Practice Patterns and Barriers to the Adoption of Esketamine

Samuel T. Wilkinson, MD; David H. Howard, PhD; Susan H. Busch, PhD

Opioid Injection in Rural Areas of the United States: A Potential Obstacle to Ending the HIV Epidemic

Andrea M. Lerner, MD; Anthony S. Fauci, MD

Reducing Pollution From the Health Care Industry

Jodi D. Sherman, MD; Andrea MacNeill, MD, FRCSC; Cassandra Thiel, PhD

A PIECE OF MY MIND

Who Heals the Healer?

Huma Farid, MD

EDITORIAL

Pelvic Organ Prolapse: Reconsidering Treatment, Innovation, and Failure

Cynthia A. Brincat, MD, PhD

Evidence-Based Treatment for Mixed Urinary Incontinence

Ingrid E. Nygaard, MD, MS

Angiotensin Receptor–Neprilysin Inhibition (ARNI) Therapy and Reverse Remodeling in Heart Failure With Reduced Ejection Fraction

Mark H. Drazner, MD, MSc

JAMA INSIGHTS

Clinical Update

Adult Immunization Update

Beverly E. Sha, MD

Video Interview: Adult Immunization Update, 2019-2020

JAMA CLINICAL CHALLENGE

Rapidly Progressive Vision Loss in a Patient With Breast Cancer

Michael C. Izzo, MD; Guri Bronner, MD; Carol L. Shields, MD

Earn CME credit

MEDICAL NEWS & PERSPECTIVES

Using Telemedicine to Treat Opioid Use Disorder in Rural Areas

Rita Rubin, MA

Quick Uptakes

Modest Calorie Reduction Can Improve Cardiometabolic Health

Rita Rubin, MA

NEWS FROM THE FOOD AND DRUG ADMINISTRATION

First Generics of Pregabalin

Feyza Sancar, PhD

New Indications for Lyme Disease Tests

Feyza Sancar, PhD

Textured Breast Implant Recall

Feyza Sancar, PhD

THE JAMA FORUM

Nursing Our Way to Better Health

David M. Cutler, PhD

GLOBAL HEALTH

Multidrug-Resistant Malaria Expands its Reach

Bridget Kuehn, MSJ

African Women’s Preferences for HIV Prevention

Bridget Kuehn, MSJ

Global Effect of Childhood Cancers

Bridget Kuehn, MSJ

POETRY AND MEDICINE

Dysthanasia

Federica Bovaro, MD

JAMA REVISITED

Social Medicine, Medical Economics and Miscellany

JAMA PATIENT PAGE

Testosterone Deficiency

Joshua A. Halpern, MD, MS; Robert E. Brannigan, MD

AUDIO

Audio Summary

Neprilysin Inhibition in Heart Failure, Comparative Effectiveness of Pelvic Organ Prolapse and Urinary Incontinence Surgery, 2019 Adult Immunization Update, and more

Clinical Review Audio

Management of Heart Failure in 2019-2020, Part 1

Clinical Review Audio

Management of Heart Failure in 2019-2020, Part 2

Audio Interview

Screening for Social Determinants of Health

COMMENT & RESPONSE

Incorporating Intimate Partner Violence Interventions in Nurse Home Visitation Programs

Leesa Hooker, PhD; Angela J. Taft, PhD

Editor's Note: Addition of an Intimate Partner Violence Intervention to a Nurse Home Visitation Program; Dara Grennan, MD; Thomas B. Cole, MD, MPH

Incorporating Intimate Partner Violence Interventions in Nurse Home Visitation Programs—Reply

Susan M. Jack, RN, PhD; David L. Olds, PhD; Harriet L. MacMillan, CM, MD

Incorporating Intimate Partner Violence Interventions in Nurse Home Visitation Programs—Reply

Thomas B. Cole, MD, MPH; Dara Grennan, MD

Editor's Note: Addition of an Intimate Partner Violence Intervention to a Nurse Home Visitation Program; Dara Grennan, MD; Thomas B. Cole, MD, MPH

Catheter Ablation Compared With Drug Therapy for Atrial Fibrillation

Marko Lucijanic, MD, PhD; Marko Skelin, MPharm; Petar Skelin, MPharm

Catheter Ablation Compared With Drug Therapy for Atrial Fibrillation

Norman C. Wang, MD, MS

Catheter Ablation Compared With Drug Therapy for Atrial Fibrillation—Reply

Douglas L. Packer, MD; Daniel B. Mark, MD, MPH; Kerry L. Lee, PhD

Optimal Gestational Weight Gain

Lisa M. Bodnar, PhD, MPH, RD; Katherine P. Himes, MD, MS; Jennifer A. Hutcheon, PhD

Optimal Gestational Weight Gain—Reply

Ellis Voerman, MSc; Vincent W. V. Jaddoe, MD, PhD; Romy Gaillard, MD, PhD; et al.

CORRECTION

Error in Figure

Deleted Footnote and Revised Footnote List in Table

Incorrect Language in Figure and Text

JAMA MASTHEAD

JAMA

Video Author Interview: Adult Immunization Update, 2019-2020

Author Interview: Management of Heart Failure in 2019-2020, Part 1 and Part 2