Antibiotics, Vol. 8, Pages 146: Carbapenemase-Producing Elizabethkingia Meningoseptica from Healthy Pigs Associated with Colistin Use in Spain Antibiotics doi: 10.3390/antibiotics8030146 Authors: Pedro Miguela-Villoldo Marta Hernández Miguel Á. Moreno David Rodríguez-Lázaro Alberto Quesada Lucas Domínguez María Ugarte-Ruiz Carbapenems are considered last-resort antimicrobials, especially for treating infections involving multidrug-resistant Gram-negative bacteria. In...
Wed Sep 11, 2019 03:00
Antibiotics, Vol. 8, Pages 145: Structural Analysis of The OXA-48 Carbapenemase Bound to A “Poor” Carbapenem Substrate, Doripenem Antibiotics doi: 10.3390/antibiotics8030145 Authors: Krisztina M. Papp-Wallace Vijay Kumar Elise T. Zeiser Scott A. Becka Focco van den Akker Carbapenem-resistant Enterobacteriaceae are a significant threat to public health, and a major resistance determinant that promotes this phenotype is the production of the OXA-48 carbapenemase. The activity...
Wed Sep 11, 2019 03:00
Antioxidants, Vol. 8, Pages 393: Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer Antioxidants doi: 10.3390/antiox8090393 Authors: Cesar Ramirez-Tortosa Ana Sanchez Cristina Perez-Ramirez Jose Luis Quiles María Robles-Almazan Mario Pulido-Moran Pedro Sanchez-Rovira MCarmen Ramirez-Tortosa The etiology of breast cancer can be very different. Most antineoplastic drugs are not selective against...
Wed Sep 11, 2019 03:00
Antioxidants, Vol. 8, Pages 392: Mitochondrial Genome (mtDNA) Mutations that Generate Reactive Oxygen Species Antioxidants doi: 10.3390/antiox8090392 Authors: Hahn Zuryn Mitochondria are critical for the energetic demands of virtually every cellular process within nucleated eukaryotic cells. They harbour multiple copies of their own genome (mtDNA), as well as the protein-synthesing systems required for the translation of vital subunits of the oxidative phosphorylation machinery...
Wed Sep 11, 2019 03:00
Antioxidants, Vol. 8, Pages 391: Preparation and Characterization of Corn Starch Bio-Active Edible Packaging Films Based on Zein Incorporated with Orange-Peel Oil Antioxidants doi: 10.3390/antiox8090391 Authors: Yue Wang Rong Zhang Saeed Ahmed Wen Qin Yaowen Liu Zein, corn starch (CS), and orange-peel oil (OPO) extracted from orange peels were used to prepare novel corn starch/orange-peel oil/zein nanocapsules (OZN) bio-active food packaging materials. The results showed...
Wed Sep 11, 2019 03:00
Antioxidants, Vol. 8, Pages 390: Zeaxanthin: Metabolism, Properties, and Antioxidant Protection of Eyes, Heart, Liver, and Skin Antioxidants doi: 10.3390/antiox8090390 Authors: Ana Gabriela Murillo Siqi Hu Maria Luz Fernandez Zeaxanthin, a non-provitamin A carotenoid that belongs to the xanthophyll family, has been less studied than its isomer lutein. However, zeaxanthin has also been shown to have a number of beneficial effects for human health due to its ability to quench free...
Wed Sep 11, 2019 03:00
Antioxidants, Vol. 8, Pages 389: Influence of Sampling Conditions, Salivary Flow, and Total Protein Content in Uric Acid Measurements in Saliva Antioxidants doi: 10.3390/antiox8090389 Authors: Jorge M. González-Hernández Lorena Franco David Colomer-Poveda Silvia Martinez-Subiela Ramón Cugat José J. Cerón Gonzalo Márquez Luis M. Martínez-Aranda Pedro Jimenez-Reyes Asta Tvarijonaviciute Uric acid (UA) is the most abundant antioxidant compound in saliva and one...
Wed Sep 11, 2019 03:00
Atmosphere, Vol. 10, Pages 540: Optical Energy Variability Induced by Speckle: The Cases of MERLIN and CHARM-F IPDA Lidar Atmosphere doi: 10.3390/atmos10090540 Authors: Cassé Gibert Edouart Chomette Crevoisier In the context of the FrenchGerman space lidar mission MERLIN (MEthane Remote LIdar missioN) dedicated to the determination of the atmospheric methane content, an end-to-end mission simulator is being developed. In order to check whether the instrument design meets...
Wed Sep 11, 2019 03:00
Atmosphere, Vol. 10, Pages 538: Air/Surface Exchange of Gaseous Elemental Mercury at Different Landscapes in Mississippi, USA Atmosphere doi: 10.3390/atmos10090538 Authors: James V. Cizdziel Yi Zhang Divya Nallamothu J. Stephen Brewer Zhiqiang Gao Mercury (Hg) is a global pollutant with human health and ecological impacts. Gas exchange between terrestrial surfaces and the atmosphere is an important route for Hg to enter and exit ecosystems. Here, we used a dynamic flux chamber...
Wed Sep 11, 2019 03:00
Atmosphere, Vol. 10, Pages 539: Use of Low-Cost Ambient Particulate Sensors in Nablus, Palestine with Application to the Assessment of Regional Dust Storms Atmosphere doi: 10.3390/atmos10090539 Authors: Abdelhaleem Khader Randal S. Martin Few air pollutant studies within the Palestinian territories have been reported in the literature. In March–April and May–June of 2018, three low-cost, locally calibrated particulate monitors (AirU’s) were deployed at...
Wed Sep 11, 2019 03:00
Atmosphere, Vol. 10, Pages 537: Added Value of Atmosphere-Ocean Coupling in a Century-Long Regional Climate Simulation Atmosphere doi: 10.3390/atmos10090537 Authors: Fanni Dóra Kelemen Cristina Primo Hendrik Feldmann Bodo Ahrens A twentieth century-long coupled atmosphere-ocean regional climate simulation with COSMO-CLM (Consortium for Small-Scale Modeling, Climate Limited-area Model) and NEMO (Nucleus for European Modelling of the Ocean) is studied here to evaluate the added...
Wed Sep 11, 2019 03:00
Behavioral Sciences, Vol. 9, Pages 98: The Bidirectional in Bilingual: Cognitive, Social and Linguistic Effects of and on Third-Age Language Learning Behavioral Sciences doi: 10.3390/bs9090098 Authors: Anna Pot Joanna Porkert Merel Keijzer Bilingualism has been put forward as a life experience that, similar to musical training or being physically active, may boost cognitive performance and slow down age-related cognitive decline. In more recent years, bilingualism has come to be...
Wed Sep 11, 2019 03:00
Behavioral Sciences, Vol. 9, Pages 97: Binge Drinking among Economically Disadvantaged African American Older Adults with Diabetes Behavioral Sciences doi: 10.3390/bs9090097 Authors: Shervin Assari James L. Smith Mohammed Saqib Mohsen Bazargan Purpose. This study investigated the effect of demographic, socioeconomic, and psychological factors as well as the role of health determinants on alcohol consumption and binge drinking among economically disadvantaged African American...
Wed Sep 11, 2019 03:00
Behavioral Sciences, Vol. 9, Pages 96: Psychological Barriers to Digital Living in Older Adults: Computer Anxiety as Predictive Mechanism for Technophobia Behavioral Sciences doi: 10.3390/bs9090096 Authors: Dina Di Giacomo Jessica Ranieri Meny D’Amico Federica Guerra Domenico Passafiume This study aimed to investigate the emotional impact of technology use in an Italian adult population and to detect technophobia. This cross-sectional study was conducted with 117 Italian...
Wed Sep 11, 2019 03:00
Bioengineering, Vol. 6, Pages 81: New Perspectives in Liver Transplantation: From Regeneration to Bioengineering Bioengineering doi: 10.3390/bioengineering6030081 Authors: Bizzaro Russo Burra Advanced liver diseases have very high morbidity and mortality due to associated complications, and liver transplantation represents the only current therapeutic option. However, due to worldwide donor shortages, new alternative approaches are mandatory for such patients. Regenerative medicine...
Wed Sep 11, 2019 03:00
Biomolecules, Vol. 9, Pages 476: The Molecular Mechanism of Epithelial–Mesenchymal Transition for Breast Carcinogenesis Biomolecules doi: 10.3390/biom9090476 Authors: Chia-Jung Li Pei-Yi Chu Giou-Teng Yiang Meng-Yu Wu The transforming growth factor-β (TGF-β) signaling pathway plays multiple regulatory roles in the tumorigenesis and development of cancer. TGF-β can inhibit the growth and proliferation of epithelial cells and induce apoptosis, thereby...
Wed Sep 11, 2019 03:00
Biomolecules, Vol. 9, Pages 475: Biodistribution and Biosafety of a Poly(Phosphorhydrazone) Dendrimer, an Anti-Inflammatory Drug-Candidate Biomolecules doi: 10.3390/biom9090475 Authors: Séverine Fruchon Elisabeth Bellard Nicolas Beton Cécile Goursat Abdelouahd Oukhrib Anne-Marie Caminade Muriel Blanzat Cédric-Olivier Turrin Muriel Golzio Rémy Poupot Dendrimers are nanosized, arborescent polymers of which size and structure are perfectly controlled. This is...
Wed Sep 11, 2019 03:00
Biomolecules, Vol. 9, Pages 474: Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence Biomolecules doi: 10.3390/biom9090474 Authors: Qing Shao Jessica L. Esseltine Tao Huang Nicole Novielli-Kuntz Jamie E. Ching Jacinda Sampson Dale W. Laird In the last couple of decades, there has been a growing optimism surrounding the potential transformative use of human mesenchymal stem cells (MSCs)...
Wed Sep 11, 2019 03:00
Brain Sciences, Vol. 9, Pages 230: Effects of High Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) on Delay Discounting in Major Depressive Disorder: An Open-Label Uncontrolled Pilot Study Brain Sciences doi: 10.3390/brainsci9090230 Authors: Juliana Teti Mayer Magali Nicolier Grégory Tio Stephane Mouchabac Emmanuel Haffen Djamila Bennabi Background: Delay discounting (DD) refers to the decrease of a present subjective value of a future reward as the delay...
Wed Sep 11, 2019 03:00
Brain Sciences, Vol. 9, Pages 229: Physiological Correlates of Moral Decision-Making in the Professional Domain Brain Sciences doi: 10.3390/brainsci9090229 Authors: Michela Balconi Giulia Fronda Moral decision-making is central to guide our social behavior, and it is based on emotional and cognitive reasoning processes. In the present research, we investigated the moral decision-making in a company context by the recording of autonomic responses (skin conductance response, heart rate...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1347: The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas Cancers doi: 10.3390/cancers11091347 Authors: Valenti Sacconi Ganci Grasso Strano Blandino Agostino Defective DNA damage response (DDR) is frequently associated with tumorigenesis. Abrogation of DDR leads to genomic instability, which is one of the most common characteristics of human cancers. TP53 mutations with gain-of-function...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1345: Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells Cancers doi: 10.3390/cancers11091345 Authors: Chun-Han Chen Tsung-Han Hsieh Yu-Chen Lin Yun-Ru Liu Jing-Ping Liou Yun Yen Anticancer therapies reportedly promote pro-survival autophagy in cancer cells that confers drug resistance, rationalizing the concept to combine autophagy inhibitors...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1348: 18F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers11091348 Authors: Laudicella Albano Alongi Argiroffi Bauckneht Baldari Bertagna Boero Vincentis Sole Rubini Fantechi Frantellizzi Ganduscio Guglielmo Nappi Evangelista on the behalf of Young AIMN Working Group Trans-1-amino-3-18F-fluorocyclobutanecarboxylic-acid (anti-[18F]-FACBC) has been approved...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1343: Epigenetic Regulation of p21cip1/waf1 in Human Cancer Cancers doi: 10.3390/cancers11091343 Authors: Matthias Ocker Samar Al Bitar Ana Carolina Monteiro Hala Gali-Muhtasib Regine Schneider-Stock p21cip1/waf1 is a central regulator of cell cycle control and survival. While mutations are rare, it is commonly dysregulated in several human cancers due to epigenetic mechanisms influencing its transcriptional control. These mechanisms include promoter...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1344: The Potential Use of Electrochemotherapy in the Treatment of Uveal Melanoma: In Vitro Results in 3D Tumor Cultures and In Vivo Results in a Chick Embryo Model Cancers doi: 10.3390/cancers11091344 Authors: Miltiadis Fiorentzis Arne Viestenz Udo Siebolts Berthold Seitz Sarah E. Coupland Joana Heinzelmann Uveal melanoma (UM) is the most common primary intraocular tumor that arises from neoplastic melanocytes in the choroid, iris, and ciliary...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1346: Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story Cancers doi: 10.3390/cancers11091346 Authors: Naffouje Grover Yu Sendilnathan Wolfe Majd Smith Takeuchi Senda Kofuji Sasaki The purine nucleotides ATP and GTP are essential precursors to DNA and RNA synthesis and fundamental for energy metabolism. Although de novo purine nucleotide biosynthesis is increased in highly proliferating cells, such...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1342: Significance of BRAF Kinase Inhibitors for Melanoma Treatment: From Bench to Bedside Cancers doi: 10.3390/cancers11091342 Authors: Taku Fujimura Yasuhiro Fujisawa Yumi Kambayashi Setsuya Aiba According to clinical trials, BRAF kinase inhibitors in combination with MEK kinase inhibitors are among the most promising chemotherapy regimens for the treatment of advanced BRAF-mutant melanoma, though the rate of BRAF mutation gene-bearing cutaneous melanoma...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1341: Local Treatment of Breast Cancer Liver Metastasis Cancers doi: 10.3390/cancers11091341 Authors: Reto Bale Daniel Putzer Peter Schullian Breast cancer represents a leading cause of death worldwide. Despite the advances in systemic therapies, the prognosis for patients with breast cancer liver metastasis (BCLM) remains poor. Especially in case of failure or cessation of systemic treatments, surgical resection for BCLMs has been considered as the treatment...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1340: Multigene Panel Testing Increases the Number of Loci Associated with Gastric Cancer Predisposition Cancers doi: 10.3390/cancers11091340 Authors: Gianluca Tedaldi Francesca Pirini Michela Tebaldi Valentina Zampiga Ilaria Cangini Rita Danesi Valentina Arcangeli Mila Ravegnani Raefa Abou Khouzam Chiara Molinari Carla Oliveira Paolo Morgagni Luca Saragoni Maria Bencivenga Paola Ulivi Dino Amadori Giovanni Martinelli...
Wed Sep 11, 2019 03:00
Cells, Vol. 8, Pages 1069: Single-Cell Transcriptomes Reveal Characteristic Features of Mouse Hepatocytes with Liver Cholestatic Injury Cells doi: 10.3390/cells8091069 Authors: Chang Tian Ji Zhou Hou Zhao Yang Yang Li Hepatocytes are the main parenchymal cells of the liver and play important roles in liver homeostasis and disease process. The heterogeneity of normal hepatocytes has been reported, but there is little knowledge about hepatocyte subtype...
Wed Sep 11, 2019 03:00
Cells, Vol. 8, Pages 1068: A Novel Chromosomal Translocation Identified due to Complex Genetic Instability in iPSC Generated for Choroideremia Cells doi: 10.3390/cells8091068 Authors: Erkilic Gatinois Torriano Bouret Sanjurjo-Soriano Luca Damodar Cereso Puechberty Sanchez-Alcudia Hamel Ayuso Meunier Pellestor Kalatzis Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely,...
Wed Sep 11, 2019 03:00
Cells, Vol. 8, Pages 1070: Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma Cells doi: 10.3390/cells8091070 Authors: Yazdanifar Zhou Grover Williams Bose Moore Wu Maher Dreau Mukherjee Chimeric antigen receptor (CAR) T cells have shown remarkable success in treating hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors....
Wed Sep 11, 2019 03:00
Cells, Vol. 8, Pages 1066: Potential Therapies Using Myogenic Stem Cells Combined with Bio-Engineering Approaches for Treatment of Muscular Dystrophies Cells doi: 10.3390/cells8091066 Authors: Motohashi Shimizu-Motohashi Roberts Aoki Muscular dystrophies (MDs) are a group of heterogeneous genetic disorders caused by mutations in the genes encoding the structural components of myofibres. The current state-of-the-art treatment is oligonucleotide-based gene therapy that restores...
Wed Sep 11, 2019 03:00
Cells, Vol. 8, Pages 1067: Detection of Androgen Receptor Variant 7 (ARV7) mRNA Levels in EpCAM-Enriched CTC Fractions for Monitoring Response to Androgen Targeting Therapies in Prostate Cancer Cells doi: 10.3390/cells8091067 Authors: Hille Gorges Riethdorf Mazel Steuber Amsberg König Peine Alix-Panabières Pantel Expression of the androgen receptor splice variant 7 (ARV7) in circulating tumor cells (CTCs) has been associated with resistance towards...
Wed Sep 11, 2019 03:00
Cells, Vol. 8, Pages 1064: Lipocalin-2 (Lcn-2) Attenuates Polymicrobial Sepsis with LPS Preconditioning (LPS Tolerance) in FcGRIIb Deficient Lupus Mice Cells doi: 10.3390/cells8091064 Authors: Thunnicha Ondee Joseph Gillen Peerapat Visitchanakun Poorichaya Somparn Jiraphorn Issara-Amphorn Cong Dang Phi Wiwat Chancharoenthana Devikala Gurusamy Aleksandra Nita-Lazar Asada Leelahavanichkul In patients with active lupus, spontaneous endotoxemia and possibly tolerance...
Wed Sep 11, 2019 03:00
Cells, Vol. 8, Pages 1065: Total DNA Methylation Changes Reflect Random Oxidative DNA Damage in Gliomas Cells doi: 10.3390/cells8091065 Authors: Anna-Maria Barciszewska Małgorzata Giel-Pietraszuk Patrick M. Perrigue Mirosława Naskręt-Barciszewska DNA modifications can be used to monitor pathological processes. We have previously shown that estimating the amount of the main DNA epigenetic mark, 5-methylcytosine (m5C), is an efficient and reliable way to diagnose brain tumors,...
Wed Sep 11, 2019 03:00
Children, Vol. 6, Pages 103: Biologic Treatment Options for Pediatric Psoriasis and Atopic Dermatitis Children doi: 10.3390/children6090103 Authors: Abigail Cline Gregory J. Bartos Lindsay C. Strowd Steven R. Feldman Background and Objectives: Severe, recalcitrant cases of pediatric psoriasis or atopic dermatitis may necessitate treatment with biological agents; however, this may be difficult due to lack of treatment options and standardized treatment guidelines. This review...
Wed Sep 11, 2019 03:00
Climate, Vol. 7, Pages 110: Spatial Process of Surface Urban Heat Island in Rapidly Growing Seoul Metropolitan Area for Sustainable Urban Planning Using Landsat Data (1996–2017) Climate doi: 10.3390/cli7090110 Authors: Prabath Priyankara Manjula Ranagalage DMSLB Dissanayake Takehiro Morimoto Yuji Murayama The urban heat island (UHI) phenomenon is an important research topic in the scholarly community. There are only few research studies related to the UHI in the Seoul metropolitan...
Wed Sep 11, 2019 03:00
Diseases, Vol. 7, Pages 53: “Not Thinking that This Means the End When You Are Seriously Ill but Doing Something Positive about It”—A Qualitative Study of Living with a Life-Changing Disease Diseases doi: 10.3390/diseases7030053 Authors: Benkel Ljungqvist Arnby Molander Background: Chronic diseases have an impact on and can change the lives of the persons affected by them. This study examines how a disease can influence patients’ daily lives, the strategies they...
Wed Sep 11, 2019 03:00
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