British Journal of Cancer, Published online: 24 September 2019; doi:10.1038/s41416-019-0591-6Correction: Desperately seeking…Models to find the right partner and the best use for checkpoint inhibitors
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British Journal of Cancer, Published online: 24 September 2019; doi:10.1038/s41416-019-0592-5Correction: Long-term outcomes of the GPOH NB97 trial for children with high-risk neuroblastoma comparing high-dose chemotherapy with autologous stem cell transplantation and oral chemotherapy as consolidation
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A third of genes in prokaryotic and eukaryotic genomes encode membrane proteins that are either essential for signal transduction, solute transport, or function as scaffold structures. Unlike many of their soluble counterparts, the overall structural and functional organization of membrane proteins are sparingly understood. Recent advances in X-ray crystallography, cryo-electron microscopy (CryoEM) and nuclear magnetic resonance (NMR) are closing this gap by enabling an in-depth view of these ever-elusive...
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Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of cell-surface immune receptors that bind to sialic acid at terminal glycan residues. Siglecs also recognize non-sialic acid ligands, many of which remain to be characterized. Here, we found that Siglec5 and Siglec14 recognize lipid compounds produced by Trichophyton, a fungal genus containing several pathogenic species. Biochemical approaches revealed that the Siglec ligands are fungal alkanes and triacylglycerols, an unexpected...
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Epithelial Na+ channel (ENaC)-mediated Na+ transport has a key role in the regulation of extracellular fluid volume, blood pressure, and extracellular [K+]. Among the thousands of human ENaC variants, only a few exist whose functional consequences have been experimentally tested. Here, we used the Xenopus oocyte expression system to investigate the functional roles of four nonsynonymous human ENaC variants located within the β7 strand and its adjacent loop of the α subunit extracellular β-ball domain....
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A beloved physician and researcher who fought the status quo to foster antibiotic stewardship, Levy dedicated his life to warning the world about the dangers of misuse. Medscape Medical News
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The worldwide expansion of macrolide-resistant Mycoplasma genitalium (MG) in cases of genital infections has led to an increased recurrence rate of these infections after first-line azithromycin treatment. By det...
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The integrated stress response (ISR) is a conserved pathway which is activated by cells that are exposed to stress. In lung adenocarcinoma (LUAD), activation of the ATF4 branch of the ISR by certain oncogenic mutations has been linked to the regulation of amino acid metabolism. In the present study, we provide evidence for ATF4 activation across multiple stages and molecular subtypes of human LUAD. In response to extracellular amino acid limitation, LUAD cells with diverse genotypes commonly induce...
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Inhibition of DNA double-strand break (DSB) repair in cancer cells has been proposed as a new therapeutic strategy for potentiating the anticancer effects of radiotherapy. M3814 is a novel, selective pharmacological inhibitor of the serine/threonine kinase DNA-dependent protein kinase (DNA-PK), a key driver of non-homologous end-joining, one of the main DSB repair pathways, currently under clinical investigation. Here, we show that M3814 effectively blocks the repair of radiation-induced DSBs and...
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The bromodomain family member proteins (BRDs; BET proteins) are key coregulators for estrogen receptor alpha (ERα)-mediated transcriptional enhancers. The use of BRD selective inhibitors has gained much attention as a potential treatment for various solid tumors, including ER-positive breast cancers. However, the roles of individual BET family members have largely remained unexplored. Here, we describe the role of BRDs in estrogen (E2)-dependent gene expression in ERα-positive breast cancer cells....
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EMT is a pivotal mechanism involved in tumor metastasis, which is the leading cause of poor prognosis for hepatocellular carcinoma (HCC). Sirtuin family members function as NAD+-dependent deacetylases that are essential for tumor metastasis and EMT. However, no causal association has been established between SIRT6 and HCC metastasis.SIRT6 expression pattern and its association with HCC metastasis were investigated by informatic analysis, and verified by RT-qPCR and immunochemistry in HCC tissues....
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J Neurol Surg BDOI: 10.1055/s-0039-1697026 Objective The main purpose of this article is to determine if vestibular schwannoma consistency as determined by tissue intensity on T2-weighted magnetic resonance imagings (MRIs) is predictive of intraoperative experience and postoperative clinical outcomes. Study Design Retrospective chart review. Setting Tertiary referral center. Patients Seventy-seven patients diagnosed with vestibular schwannomas who were...
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Abstract The conservation of plant genetic resources is essential for breeding programs. Regarding the native species of the Brazilian Cerrado biome, many studies have demonstrated their high potential for use in both medicines and foods. Hymenaea stigonocarpa, a tree with wide occurrence in the Cerrado, has economic importance, and due its extractive use, the establishment of a breeding program is relevant for sustainable use and conservation. Thus, the first germplasm collection...
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TUESDAY, Sept. 24, 2019 -- A 50-year-old man has become the second patient in Kansas to die from lung damage tied to electronic cigarette use. That brings the national total of deaths from this illness to nine, CNN reported. So far, the number of...
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TUESDAY, Sept. 24, 2019 -- The recall of the commonly prescribed blood pressure drug losartan has been expanded once again to include an additional five lots. The drug, made by Torrent Pharmaceuticals, has been recalled because some lots are...
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TUESDAY, Sept. 24, 2019 -- In 2016, American and Canadian diplomats in Cuba complained of vertigo, ringing in the ears, pain, blurred vision, dizziness, and memory and concentration problems. The U.S. feared a Cuban-directed "sonic attack." Cuba...
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The 123rd American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting and OTO Experience The annual meeting of the American Academy of Otolaryngology-Head and Neck Surgery was held from Sept. 15 to 18 in New Orleans and...
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TUESDAY, Sept. 24, 2019 -- The U.S. Preventive Services Task Force (USPSTF) recommends using a urine culture to screen pregnant persons for asymptomatic bacteriuria (Grade B recommendation) but does not recommend screening nonpregnant adults. These...
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TUESDAY, Sept. 24, 2019 -- Among older individuals with type 2 diabetes, those with poor health have more prevalent insulin use, according to a study published online Sept. 23 in JAMA Internal Medicine. Jonathan Z. Weiner, M.D., M.P.H., from Kaiser...
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TUESDAY, Sept. 24, 2019 -- Increasing daily consumption of nuts is associated with less long-term weight gain and a lower risk for obesity in adults, according to a study published online Sept. 23 in BMJ Nutrition, Prevention & Health. Xiaoran...
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TUESDAY, Sept. 24, 2019 -- There is a strong association between 25-hydroxyvitamin D (25[OH]D) deficiency (<50 nmol/L) and increased mortality, particularly for diabetes-related deaths, according to a study presented at the annual meeting of the...
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TUESDAY, Sept. 24, 2019 -- From 1999 to 2016, the percentage of women in internal medicine residencies increased, but the percentage in subspecialty fellowships decreased, according to a research letter published online Sept. 23 in JAMA Internal...
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TUESDAY, Sept. 24, 2019 -- Young female athletes take longer than young male athletes to recover from sports-related concussion (SRC), according to research published in the September issue of the Clinical Journal of Sport Medicine. Natasha Desai,...
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TUESDAY, Sept. 24, 2019 -- Women with frequent or persistent vasomotor symptoms (VMS) during the menopause transition have an increased risk for cardiovascular disease (CVD) events, according to a study presented at the annual meeting of the North...
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TUESDAY, Sept. 24, 2019 -- A stepped care approach seems beneficial for insomnia treatment among cancer survivors, according to a study published online Sept. 24 in Cancer. Eric S. Zhou, Ph.D., from the Dana-Farber Cancer Institute in Boston, and...
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TUESDAY, Sept. 24, 2019 -- From 2014 to 2018, current and daily electronic cigarette use increased among U.S. young adults but declined or remained stable in older age groups, according to a research letter published online Sept. 16 in the Journal...
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TUESDAY, Sept. 24, 2019 -- Living through a hurricane increases both the short- and long-term risk for death among seniors with diabetes, according to a study published online Sept. 23 in Diabetes Care. Troy Quast, Ph.D., from the University of...
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TUESDAY, Sept. 24, 2019 -- Automated machine learning (ML) analysis has the potential to provide faster analysis of cardiovascular magnetic resonance imaging (CMR) with similar levels of precision, according to a study published online Sept. 24 in...
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Medtronic has just revealed its modular Robot-Assisted Surgery system.Based on their Form 8-K, "The Investor Update included a RAS prostatectomy procedure performed in a cadaveric lab as part of the Medtronic Minimally Invasive Therapy Group’s ongoing development and testing process of its RAS technology, as well as a short procedure overview with pre-recorded video from a recent cadaveric procedure that was also part of the Company’s ongoing development and testing process. Medtronic’s RAS technology...
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5 percutaneous coronary intervention (PCI) procedures performed 20 miles away with Corindusvascular robot in India Stryker acquires Cardan Robotics and Mobius Imaging for $500m Interview with Anthony Fernando - COO/CTO TransEnterix Edinburgh hospital is among firsts to get the £427,000 Versius robotKeranova raises $26.5 million for ophthalmic surgical robot Transenterix reports sales of $5.82 m for H1, 0.52x the revenue of H1 2018 CMR Surgical raised $243 million in a Series C, pushing the co's...
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"Machnet Medical Robotics is a new spinoff that utilises knowledge developed at the University of Twente. The company, which is located in Twente, is developing a robot for MRI-guided biopsies. The application is primarily focused on taking biopsies of early-stage breast cancer. The University of Twente and the existing company Machnet Holding BV are both shareholders in Machnet Medical Robotics BV.According to Jeroen Veltman, who works as a radiologist at Ziekenhuisgroep Twente and is closely involved...
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Objectives. The importance of preventive medicine in an aging society is increasing. Locomotive syndrome (LS) is attracting increasing attention. Recently, advances in bioelectrical impedance analysis (BIA) devices have made it possible to automatically measure waist circumference (WC). Nevertheless, there have been no reports evaluating the agreement or interchangeability between WC measured manually and using BIA. Therefore, we aimed to perform these analyses in the context of health checkups and...
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The main objective of this research was to evaluate the efficacy of intermittent hypoxic training (IHT) on aiming performance and aerobic capacity in biathletes. Fourteen male biathletes were randomly divided into a hypoxia group (H) (n = 7), which trained three times per week in a normobaric hypoxic environment (FiO2 = 16.5%, 2000 m a.s.l.) with lactate threshold intensity (LT) determined in hypoxia, and a control group (C) (n = 7), which exercised under normoxic conditions with LT intensity determined...
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Globe artichoke is an intriguing source of indigestible sugar polymers such as inulin-type fructans. In this study, the effect of ultrasound in combination with ethanol precipitation to enhance the extraction of long chain fructans from artichoke wastes has been evaluated. The inulin-type fructans content both from bracts and stems was measured using an enzymatic fructanase-based assay, while its average degree of polymerization (DP) was determined by HPLC-RID analysis. Results show that this method...
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Bacteria in biofilms are encased in an extracellular polymeric matrix that limits exposure of microbial cells to lethal doses of antimicrobial agents, leading to resistance. In Pseudomonas aeruginosa, biofilm formation is regulated by cell-to-cell communication, called quorum sensing. Quorum sensing facilitates a variety of bacterial physiological functions such as swarming motility and protease, pyoverdine, and pyocyanin productions. Peptide mix from the marine mollusc, Olivancillaria hiatula, has...
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