Related ArticlesParaneoplastic opsoclonus-myoclonus syndrome secondary to melanoma metastasis form occult primary cancer. Case Rep Neurol. 2019 Jan-Apr;11(1):66-79 Authors: Mondragón JD, Jiménez-Zarazúa O, Vélez-Ramírez LN, Martínez-Rivera MA, Enríquez-Maciel S, González-Guzmán J, Alvarez-Delgado MM, González-Carrillo PL Abstract Introduction: Opsoclonus-myoclonus syndrome (OMS) is an inflammatory neurological disorder, often requiring a prompt medical...
20h
Related ArticlesElectrochemotherapy and Ablative Therapies in Non-melanoma Skin Cancer. Clin Oncol (R Coll Radiol). 2019 Sep 19;: Authors: O'Donoghue N, Mowatt D, Sykes AJ Abstract Although surgery and radiotherapy remain the most commonly used treatments for non-melanoma skin cancer, there are a variety of alternatives. Here we discuss the use of electrochemotherapy and ablative treatments and examine the evidence for their effectiveness against a number...
20h
Related ArticlesResearch Techniques Made Simple: Feature Selection for Biomarker Discovery. J Invest Dermatol. 2019 Oct;139(10):2068-2074.e1 Authors: Torres R, Judson-Torres RL Abstract Molecular biomarkers can be powerful tools for aiding in the efficiency and precision of clinical decision-making. Feature selection methods, machine-learning, and biostatistics have been applied to discover subsets of molecular markers that identify target classes of...
20h
Related ArticlesPARANEOPLASTIC VITELLIFORM MACULOPATHY - ASSOCIATION WITH PRIMARY CANCERS. Ulster Med J. 2018 Oct;87(3):199-200 Authors: PMID: 31105353 [PubMed - indexed for MEDLINE]
20h
Related ArticlesObservation of Moderately Dysplastic Nevi With Positive Margins: Are We There Yet? JAMA Dermatol. 2018 12 01;154(12):1387-1388 Authors: Adamson AS, Nelson KC PMID: 30304351 [PubMed - indexed for MEDLINE]
20h
Related ArticlesCardiotoxicity mechanisms of the combination of BRAF-inhibitors and MEK-inhibitors. Pharmacol Ther. 2018 12;192:65-73 Authors: Bronte E, Bronte G, Novo G, Rinaldi G, Bronte F, Passiglia F, Russo A Abstract Many new drugs have appeared in last years in the oncological treatment scenario. Each drug carries an important set of adverse events, not less, cardiovascular adverse events. This aspect is even more important considering the increasing...
20h
Related ArticlesApplication of in vivo reflectance confocal microscopy and ex vivo fluorescence confocal microscopy in the most common subtypes of basal cell carcinoma and correlation with histopathology. Br J Dermatol. 2018 05;178(5):1215-1217 Authors: Villarreal-Martinez A, Bennàssar A, Gonzalez S, Malvehy J, Puig S PMID: 29405259 [PubMed - indexed for MEDLINE]
20h
Related ArticlesRepair of a Full-Thickness Defect of the Lower Eyelid Margin. Dermatol Surg. 2019 06;45(6):845-847 Authors: Kohli N, Bordeaux JS PMID: 29016536 [PubMed - indexed for MEDLINE]
20h
Squalene is a major sebum lipid which is easily peroxidized by ultraviolet A (UVA) irradiation, generating products that can stress keratinocytes. Prevention of squalene photooxidation with antioxidants could potentially help defend skin from environmental stress. Previously, we have systematically characterized butylated caffeic acid (BCA) as a more lipophilic alternative of caffeic acid (CA). The current study aimed to test the hypothesis that the lipophilic property of BCA makes it a good candidate...
20h
Related ArticlesSurgery for patellar tendinopathy (jumper's knee). Cochrane Database Syst Rev. 2019 Sep 23;9:CD013034 Authors: Dan M, Phillips A, Johnston RV, Harris IA Abstract BACKGROUND: Patellar tendinopathy is an overuse condition that commonly affects athletes. Surgery is usually offered if medical and physical therapies fail to treat it effectively. There is variation in the type of surgery performed for the condition. OBJECTIVES: To...
20h
Related ArticlesPerioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing cardiac surgery. Cochrane Database Syst Rev. 2019 Sep 23;9:CD013435 Authors: Blessberger H, Lewis SR, Pritchard MW, Fawcett LJ, Domanovits H, Schlager O, Wildner B, Kammler J, Steinwender C Abstract BACKGROUND: Randomized controlled trials (RCTs) have yielded conflicting results regarding the ability of beta-blockers to influence perioperative...
20h
Related Articles[E-health and "Cancer outside the hospital walls", Big Data and artificial intelligence]. Bull Cancer. 2019 Sep 19;: Authors: Bertucci F, Le Corroller-Soriano AG, Monneur A, Fluzin S, Viens P, Maraninchi D, Goncalves A Abstract To heal otherwise in oncology has become an imperative of Public Health and an economic imperative in France. Patients can therefore receive live most of their care outside of hospital with more ambulatory care....
20h
Flow diagram of the studies screened for eligibility and included in the review. Abstract What is known and objective Capsaicin, the major active ingredient of chili pepper, may play a “dual role” in tumourigenesis, acting as a carcinogen or as a cancer preventive agent. The aim of this study was to investigate the anticancer mechanisms of capsaicin and the effects of capsaicin on traditional chemotherapeutic drugs and radiotherapy in various cancer types and the potential for clinical application...
20h
Markers of oxidative stress and inflammation were assessed in non‐small cell lung cancer (NSCLC) patients before treatment and after first cycle of chemotherapy. Significant decrease in IL‐6 levels in partial responders indicates that IL‐6 may be a potential marker of treatment response in NSCLC patients. Abstract What is known and objective Oxidative stress and inflammation are known to be high in non‐small cell lung cancer (NSCLC). However, association of change in their levels with treatment...
20h
We present a case of a 30‐year‐old female who developed acute severe oral ulcerative mucositis with degree IV myelosuppression and degree III hepatic injury, after 3 doses of low‐dose methotrexate (LDMTX) to treat placenta accrete. This case indicated that early recognition of this potentially life‐threatening complication and immediate leucovorin rescue will usually result in the patient's favorable outcome. Abstract What is known and objective Low‐dose methotrexate (LDMTX) has been widely...
20h
Abstract What is known and objective Ganciclovir is a first‐line antiviral agent to treat cytomegalovirus disease in immunocomprimised patients. Ganciclovir pharmacokinetics in ECMO is unknown. Case description A 6‐year‐old with a stage IV extra‐renal rhabdoid tumor with respiratory failure leading to extracorporeal membrane oxygenation had increasing serum CMV DNAemia while on ganciclovir. What is new and conclusion This is the first case report of ganciclovir pharmacokinetics in...
20h
Related ArticlesA Case of Cutaneous Larva Migrans in a Child from Vinces, Ecuador. Am J Case Rep. 2019 Sep 23;20:1402-1406 Authors: Coello RD, Pazmiño BJ, Reyes EO, Rodríguez EX, Rodas EI, Rodas KA, Dávila AX, Rodas JP, Cedeño PP Abstract BACKGROUND Cutaneous larva migrans (CLM) is caused by nematode parasites of the hookworm family of Ancylostomatidae. Ancylostomiasis is a zoonosis found in cats and dogs, and humans are an accidental host. This report...
20h
Related ArticlesUse of Micro X-ray Computed Tomography with Phosphotungstic Acid Preparation to Visualize Human Fibromuscular Tissue. J Vis Exp. 2019 Sep 05;(151): Authors: O J, Kwon HJ, Kim SH, Cho TH, Yang HM Abstract Manual dissection and histological observation are common methods used to investigate human tissues. However, manual dissection can damage delicate structures while processing and histological observation provide limited information through...
20h
Related ArticlesFlow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia. J Vis Exp. 2019 Sep 05;(151): Authors: Di Marcantonio D, Sykes SM Abstract We present a flow cytometric approach for analyzing mitochondrial ROS in various live bone marrow (BM)-derived stem and progenitor cell populations from healthy mice as well as mice with AML driven by MLL-AF9. Specifically,...
20h
Related ArticlesExamining Online Syntactic Processing of Spoken Complex Sentences in Chinese Using Dual-Modal Interference Tasks. J Vis Exp. 2019 Sep 05;(151): Authors: Cheng T, Wu JT Abstract Working memory (WM) plays a central role in the comprehension of complex sentences. Its function in the processing of spoken complex sentences is especially evident because spoken complex sentence processing is memory-intensive. The dual-modal interference paradigm...
20h
Related ArticlesA Photonic System for Generating Unconditional Polarization-Entangled Photons Based on Multiple Quantum Interference. J Vis Exp. 2019 Sep 05;(151): Authors: Terashima H, Sato Y, Kobayashi S, Tsubakiyama T, Nozaki R, Kubo S, Osada T, Sanaka K Abstract We present a high-performance source of unconditional polarization-entangled photons that have a high-emission rate, a broadband distribution, are degenerated and postselection free. The...
20h
Related ArticlesIdentifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan. J Vis Exp. 2019 Sep 07;(151): Authors: Bai QR, Dong L, Shen Q Abstract Neural stem and progenitor cells (NSPCs) are the cellular basis for the complex structures and functions of the brain. They are located in specialized niches in vivo and can be isolated and expanded in vitro, serving as an important resource for cell transplantation...
20h
Related ArticlesPooled CRISPR-Based Genetic Screens in Mammalian Cells. J Vis Exp. 2019 Sep 04;(151): Authors: Chan K, Tong AHY, Brown KR, Mero P, Moffat J Abstract Genome editing using the CRISPR-Cas system has vastly advanced the ability to precisely edit the genomes of various organisms. In the context of mammalian cells, this technology represents a novel means to perform genome-wide genetic screens for functional genomics studies. Libraries of guide...
20h
Related ArticlesApplication of 3D Printing in the Construction of Burr Hole Ring for Deep Brain Stimulation Implants. J Vis Exp. 2019 Sep 07;(151): Authors: Chen J, Chen X, Lv S, Zhang Y, Long H, Yang K, Qi S, Zhang W, Wang J Abstract 3D printing has been widely applied in the medical field since the 1980s, especially in surgery, such as preoperative simulation, anatomical learning and surgical training. This raises the possibility of using 3D printing...
20h
Related ArticlesMicroinjection of DNA into Eyebuds in Xenopus laevis Embryos and Imaging of GFP Expressing Optic Axonal Arbors in Intact, Living Xenopus Tadpoles. J Vis Exp. 2019 Sep 04;(151): Authors: Dao S, Jones K, Elul T Abstract The primary visual projection of tadpoles of the aquatic frog Xenopus laevis serves as an excellent model system for studying mechanisms that regulate the development of neuronal connectivity. During establishment of the...
20h
Related ArticlesA FACS-based Protocol to Isolate RNA from the Secondary Cells of Drosophila Male Accessory Glands. J Vis Exp. 2019 Sep 05;(151): Authors: Immarigeon C, Karch F, Maeda RK Abstract To understand the function of an organ, it is often useful to understand the role of its constituent cell populations. Unfortunately, the rarity of individual cell populations often makes it difficult to obtain enough material for molecular studies. For example,...
20h
Related ArticlesIon Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides. J Vis Exp. 2019 Sep 07;(151): Authors: Yousef EN, Sesham R, McCabe JW, Vangala R, Angel LA Abstract Electrospray ionization (ESI) can transfer an aqueous-phase peptide or peptide complex to the gas-phase while conserving its mass, overall charge, metal-binding interactions,...
20h
Related ArticlesHierarchical and Programmable One-Pot Oligosaccharide Synthesis. J Vis Exp. 2019 Sep 06;(151): Authors: Cheng CW, Zhou Y, Pan WH, Dey S, Wu CY, Hsu WL, Wong CH Abstract This article presents a general experimental protocol for programmable one-pot oligosaccharide synthesis and demonstrates how to use Auto-CHO software for generating potential synthetic solutions. The programmable one-pot oligosaccharide synthesis approach is designed...
20h
Related ArticlesA Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences. J Vis Exp. 2019 Sep 04;(151): Authors: Villanueva I, Husman J, Christensen D, Youmans K, Khan MT, Vicioso P, Lampkins S, Graham MC Abstract Over the past ten years, research into students' emotions in educational environments has increased. Although researchers have called for more studies that rely on objective measures...
20h
Related ArticlesSplit Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements. J Vis Exp. 2019 Sep 07;(151): Authors: Conrad BM, Johnson MR Abstract Researchers from myriad fields frequently seek to quantify and classify concentrations of carbonaceous aerosols as organic carbon (OC) or elemental carbon (EC). This is commonly accomplished using thermal-optical OC/EC analyzers (TOAs), which enable measurement...
20h
Related ArticlesIsolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets. J Vis Exp. 2019 Sep 06;(151): Authors: Powell RLR, Fox A Abstract Even in the absence of antiretroviral drugs, only ~15% of infants breastfed by HIV-infected mothers become infected, suggesting a strong protective effect of breast milk (BM). Unless access to clean water and appropriate infant formula is reliable,...
20h
Related ArticlesRapid Isolation of Dorsal Root Ganglion Macrophages. J Vis Exp. 2019 Sep 07;(151): Authors: Yu X, Leff J, Guan Z Abstract There are growing interests to study the molecular and cellular interactions among immune cells and sensory neurons in the dorsal root ganglia after peripheral nerve injury. Peripheral monocytic cells, including macrophages, are known to respond to a tissue injury through phagocytosis, antigen presentation, and cytokine...
20h
Related ArticlesSingle-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules. J Vis Exp. 2019 Sep 05;(151): Authors: Rocha JM, Gahlmann A Abstract Single-molecule localization microscopy probes the position and motions of individual molecules in living cells with tens of nanometer spatial and millisecond temporal resolution. These capabilities make single-molecule localization microscopy ideally suited to study...
20h
Vaccines, Vol. 7, Pages 128: Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children Vaccines doi: 10.3390/vaccines7040128 Authors: Lorenzo Lodi Silvia Ricci Francesco Nieddu Maria Moriondo Francesca Lippi Clementina Canessa Giusi Mangone Martina Cortimiglia Arianna Casini Ersilia Lucenteforte Giuseppe Indolfi Massimo Resti Chiara Azzari The effectiveness and...
20h
Vaccines, Vol. 7, Pages 127: Food Additives as Novel Influenza Vaccine Adjuvants Vaccines doi: 10.3390/vaccines7040127 Authors: Huapeng Feng Makoto Yamashita Li Wu Tiago Jose da Silva Lopes Tokiko Watanabe Yoshihiro Kawaoka Influenza is a major threat to public health. Vaccination is an effective strategy to control influenza; however, the current inactivated influenza vaccine has mild immunogenicity and exhibits suboptimal efficacy in clinical use. Vaccine efficacy can...
23h
Publication date: Available online 23 September 2019Source: Journal of Cultural HeritageAuthor(s): Lucie Blahová, Jakub Horák, Radek Přikryl, Jan Pekárek, Jakub Tkacz, Přemysl Menčík, František KrčmaAbstractCombinations of different acrylic resins and microcrystalline waxes are most often used for conservation and preservation these days. However, their properties are not sufficient and satisfactory in many ways. A novel barrier coating for the conservation of iron archaeological artefacts composed...
20h
Summary Pulmonary complications have a significant impact on morbidity and mortality in patients after major surgery. Lung ultrasound can be used at the bed‐side, and has gained widespread acceptance in the intensive care unit. We conducted a prospective study to evaluate whether lung ultrasound could be used as a predictive marker for postoperative ventilatory support in high‐risk surgical patients. We included 109 patients admitted to the intensive care unit while having mechanical ventilation...
20h
Summary Delirium is a common complication following hip fracture surgery. We introduced a peri‐operative care bundle that standardised management in the emergency department, operating theatre and ward. This incorporated: use of fascia iliaca blocks; rationalisation of analgesia; avoidance of drugs known to trigger delirium; a regular education program for staff; and continuous auditing of compliance. The study was conducted between June 2017 and December 2018. We recruited 150 patients before (control...
20h
Abstract In 2014, this journal reported for the first time a series of 6 cases of Primordial Odontogenic Tumor (POT)1, a new entity which was subsequently included in the fourth edition of the World Health Organization (WHO) classification of the Head and Neck Tumors2. Since the first report, 9 more cases from various areas of the world have been reported, reaching a total of 15 cases.
21h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου