Antibiotics, Vol. 8, Pages 165: Stability of Biological Activity of Frozen β-lactams over Time as Assessed by Time-Lapsed Broth Microdilutions Antibiotics doi: 10.3390/antibiotics8040165 Authors: Gleice Leite Alexander Lawandi Matthew P. Cheng Todd Lee To evaluate the antimicrobial agent’s stability stored at −80 °C, six β-lactams (meropenem, ertapenem, imipenem, ceftriaxone, ceftazidime, and piperacillin-tazobactam) were studied using the...
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Publication date: Available online 24 September 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Jucimara Baldissarelli, Aline Mânica, Micheli Mainardi Pillat, Margarete Dulce Bagatini, Daniela Bitencourt Leal, Fátima Husein Abdalla, Vera M. Morsch, Henning Ulrich, Clarissa Pereira Bornemann, Maria R. Chitolina SchetingerAbstractThyroid hormones have essential roles in regulation of cellular functions, including the immune system. The purinergic signaling, activated through extracellular...
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Publication date: Available online 23 September 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Dan Zhang, Hong-Yuan Tang, Li Tan, Dong-Mei ZhaoAbstractPolycystic ovary syndrome (PCOS) is an endocrine disorder, the etiology of which is complex and unclear. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a conserved long non-coding RNA which has been found to play a role in the pathophysiological process of reproductive system diseases, such as endometriosis and pregnancy...
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Related ArticlesTime, Resident Involvement, and Supply Drive Cost Variability in Septoplasty with Turbinate Reduction. Otolaryngol Head Neck Surg. 2018 08;159(2):310-314 Authors: Quinn NA, Alt JA, Ashby S, Orlandi RR Abstract Objective To determine factors that influence cost variability in septoplasty with inferior turbinate reduction. Study Design Case series with chart review. Setting Tertiary care hospital and affiliated ambulatory surgical center....
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Related ArticlesClassification of Spreader Flap Techniques. Facial Plast Surg. 2017 08;33(4):453 Authors: Seyhan A PMID: 28753723 [PubMed - indexed for MEDLINE]
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Related ArticlesPreliminary study on the efficacy of xerostomia treatment with sialocentesis targeting thyroid disease patients given radioiodine therapy. Maxillofac Plast Reconstr Surg. 2019 Dec;41(1):39 Authors: Kim EH, Lee DK, Kim CW, Song IS, Jun SH Abstract Background: Radioiodine therapy has been widely used for thyroid disease patients, but hyposalivation and xerostomia may occur in 10~30% of patients. Sialocentesis is a procedure that removes...
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Related ArticlesR-CHOP-Associated Graves' Hyperthyroidism. Case Rep Oncol. 2019 May-Aug;12(2):581-588 Authors: Mora N, Vu KN, Hoang TD, Mai VQ, Shakir MKM Abstract Radiation-induced thyroid dysfunction following oncologic treatment is not uncommon, however limited literature data has been found on patients that underwent chemotherapy only. A change in thyrometabolic autoimmune status is also a rare entity. We present a case of newly diagnosed Graves'...
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Related ArticlesSurgery alone for papillary thyroid microcarcinoma is less costly and more effective than long term active surveillance. Surgery. 2019 Sep 19;: Authors: Lin JF, Jonker PKC, Cunich M, Sidhu SB, Delbridge LW, Glover AR, Learoyd DL, Aniss A, Kruijff S, Sywak MS Abstract BACKGROUND: Papillary thyroid microcarcinoma is a subtype of thyroid cancer that may be managed with active surveillance rather than immediate surgery. Active surveillance...
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Preoperative Localization of Recurrence in the Thyroidectomy Bed Using a Radioactive Iodine125 Seed.
Related ArticlesPreoperative Localization of Recurrence in the Thyroidectomy Bed Using a Radioactive Iodine125 Seed. Otolaryngol Head Neck Surg. 2018 08;159(2):394-397 Authors: Garner HW, Paz-Fumagalli R, Young GD Abstract Intraoperative localization of nonpalpable recurrent thyroid cancer has been reported using needle localization, intraoperative ultrasound (US), dye injection, and radio-guided surgery. We describe the alternative technique of radioactive...
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Publication date: Available online 23 September 2019Source: The Lancet Infectious DiseasesAuthor(s): Dora Buonfrate, Joaquin Salas-Coronas, José Muñoz, Begoña Trevino Maruri, Paola Rodari, Francesco Castelli, Lorenzo Zammarchi, Leila Bianchi, Federico Gobbi, Teresa Cabezas-Fernández, Ana Requena-Mendez, Gauri Godbole, Ronaldo Silva, Marilena Romero, Peter L Chiodini, Zeno BisoffiSummaryBackgroundStrongyloides stercoralis infection is a neglected condition that places people who are immunocompromised...
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Publication date: Available online 23 September 2019Source: The Lancet Infectious DiseasesAuthor(s): Eveline Hürlimann, Jennifer Keiser
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Abstract Purpose The study had three aims. We investigated, first, how six recovery experiences (i.e., detachment, relaxation, control, mastery, meaning, and affiliation) during off-job time suggested by the DRAMMA model (Newman et al. in J Happiness Stud 15(3):555–578. https://doi.org/10.1007/s10902-013-9435-x, 2014) are related to well-being (i.e., vitality, life satisfaction, and work ability). Second, we examined how age related to...
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Related ArticlesNon-conventional doses of somatostatin analogs in patients with progressing well differentiated neuroendocrine tumor. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Lamberti G, Faggiano A, Brighi N, Tafuto S, Ibrahim T, Brizzi MP, Pusceddu S, Albertelli M, Massironi S, Panzuto F, Badalamenti G, Riccardi F, Butturini G, Gelsomino F, De Divitiis C, Modica R, Bongiovanni A, La Salvia A, Torchio M, Colao A, Ferone D, Campana D, ItaNet Abstract ...
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Related ArticlesThe prevalence of osteoporosis tested by quantitative computed tomography in patients with different glucose tolerances. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Zhao Z, Wang L, Fu Z, Ji L, Li Y, Wu X Abstract AIM: The objectives of the present study were to compare bone characteristics with QCT and other metabolic factors relevant to bone health in subjects with normal glucose tolerance, impaired glucose tolerance and diabetes...
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Related ArticlesSex hormone replacement therapy in Turner Syndrome - impact on morbidity and mortality. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Viuff MH, Berglund A, Juul S, Andersen NH, Stochholm K, Gravholt CH Abstract CONTEXT: The long-term effects of female hormone replacement therapy (HRT) in Turner syndrome (TS) are unknown. OBJECTIVE: To examine morbidity, mortality and medicinal use in TS and the impact of HRT in 45,X women....
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Related ArticlesWeight Change and Development of Subclinical Carotid Atherosclerosis Among Metabolically Healthy Adults: A Cohort Study. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Sinn DH, Kang D, Cho SJ, Chang Y, Ryu S, Song YB, Paik SW, Hong YS, Zhao D, Guallar E, Cho J, Gwak GY Abstract BACKGROUND: The benefit of weight loss for reducing cardiovascular disease (CVD) risk in metabolically healthy obese people is unknown. OBJECTIVES: We...
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Related ArticlesComparison between total thyroidectomy and medical therapy for amiodarone-induced thyrotoxicosis. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Cappellani D, Papini P, Pingitore A, Tomisti L, Mantuano M, Di Certo AM, Manetti L, Marconcini G, Scattina I, Urbani C, Morganti R, Marcocci C, Materazzi G, Iervasi G, Martino E, Bartalena L, Bogazzi F Abstract CONTEXT: It is not known whether total thyroidectomy is more favourable than medical...
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Related ArticlesFibroblast activation protein is a GH target: A prospective study of patients with acromegaly before and after treatment. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Arlien-Søborg MC, Grøndahl C, Bæk A, Dal J, Alle Madsen M, Høgild ML, Pedersen SB, Bjerre M, Jørgensen JOL Abstract BACKGROUND: Fibroblast growth factor 21 (FGF21) is a circulating hormone with pleiotropic metabolic effects, which is inactivated by fibroblast activation...
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Related ArticlesIGF2 Mutations: Report of Five Cases, Review of the Literature, and Comparison with H19/IGF2:IG-DMR Epimutations. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Masunaga Y, Inoue T, Yamoto K, Fujisawa Y, Sato Y, Kawashima-Sonoyama Y, Morisada N, Iijima K, Ohata Y, Namba N, Suzumura H, Kuribayashi R, Yamaguchi Y, Yoshihashi H, Fukami M, Saitsu H, Kagami M, Ogata T Abstract OBJECTIVE: IGF2 is a paternally expressed growth-promoting gene....
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Related ArticlesBody composition and markers of cardiometabolic health in transgender youth compared to cisgender youth. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Nokoff NJ, Scarbro SL, Moreau KL, Zeitler P, Nadeau KJ, Juarez-Colunga E, Kelsey MM Abstract CONTEXT: Up to 1.8% of adolescents identify as transgender and many more seek care, yet the impact of gender affirming hormone therapy (GAHT) on cardiometabolic health is unknown. OBJECTIVE:...
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Related ArticlesPioglitazone Exposure Reduced the Risk of All-Cause Mortality in Insulin-Treated Patients with Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2019 Sep 23;: Authors: Yen FS, Wang HC, Pan CW, Wei JC, Hsu CC, Hwu CM Abstract CONTEXT: The long-term safety and benefit of pioglitazone use in combination with insulin are still uncertain. OBJECTIVE: This study compared the risks of all-cause mortality and major cardiovascular (CV)...
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Related ArticlesTranslating Mesothelioma Molecular Genomics and Dependencies into Precision Oncology-Based Therapies. Semin Cancer Biol. 2019 Sep 20;: Authors: Hinz TK, Heasley LE Abstract Malignant pleural mesothelioma (MPM) is a rare, yet lethal asbestos-induced cancer and despite marked efforts to reduce occupational exposure, the incidence has not yet significantly declined. Since 2003, combined treatment with a platinum-based agent and pemetrexed...
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Related ArticlesProgressive Transfer Learning and Adversarial Domain Adaptation for Cross-Domain Skin Disease Classification. IEEE J Biomed Health Inform. 2019 Sep 23;: Authors: Gu Y, Ge Z, Bonnington CP, Zhou J Abstract Deep learning has been used to analyze and diag-nose various skin diseases through medical imaging. However,recent researches show that a well trained deep learning modelmay not generalize well to data from different cohorts due todomain...
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Related ArticlesFactors associated with skin cancer in lung transplant recipients: A single-center experience. Clin Transplant. 2019 Sep 23;:e13718 Authors: Elnahas S, Olson MT, Kang P, Panchanathan R, Masuda T, Walia R, Zeitouni NC, Smith MA, Bremner RM Abstract BACKGROUND: Skin cancer is common after solid organ transplantation, but few have investigated it after lung transplant (LTx). OBJECTIVE: We assessed incidence and predictors of non-melanoma...
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Related ArticlesLong-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase 2 randomised, double-blind BOLT study. Br J Dermatol. 2019 Sep 23;: Authors: Dummer R, Guminksi A, Gutzmer R, Lear JT, Lewis KD, Chang ALS, Combemale P, Dirix L, Kaatz M, Kudchadkar R, Loquai C, Plummer R, Schulze HJ, Stratigos AJ, Trefzer U, Squittieri N, Migden MR Abstract BACKGROUND: Basal cell carcinomas (BCCs)...
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Related ArticlesCore‑shell type thermo‑nanoparticles loaded with temozolomide combined with photothermal therapy in melanoma cells. Oncol Rep. 2019 Sep 20;: Authors: Hou X, Pang Y, Li X, Yang C, Liu W, Jiang G, Liu Y Abstract A novel core‑shell type thermo‑nanoparticle (CSTNP) co‑loaded with temozolomide (TMZ) and the fluorescein new indocyanine green dye IR820 (termed IT‑CSTNPs) was designed and combined with a near‑infrared (NIR) laser to realize its...
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Related ArticlesSerum proteomic analysis of melanoma patients with immunohistochemical profiling of primary melanomas and cultured cells: Pilot study. Oncol Rep. 2019 Sep 17;: Authors: Kučera J, Strnadová K, Dvořánková B, Lacina L, Krajsová I, Štork J, Kovářová H, Skalníková HK, Vodička P, Motlík J, Dundr P, Smetana K, Kodet O Abstract The steadily increasing incidence of malignant melanoma (MM) and its aggressive behaviour makes this tumour an attractive...
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Related ArticlesSelective uveal melanoma inhibition with calcium channel blockade. Int J Oncol. 2019 Sep 06;: Authors: Shaughnessy M, Lamuraglia G, Klebanov N, Ji Z, Rajadurai A, Kumar R, Flaherty K, Tsao H Abstract Uveal malignant melanoma (UMM), the most common primary adult intraocular tumor with a marked metastatic potential, is genetically unique and has unfortunately had few treatment breakthroughs. In this study, we subjected a UMM cell line to...
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Related ArticlesGRWD1 directly interacts with p53 and negatively regulates p53 transcriptional activity. J Biochem. 2019 Sep 23;: Authors: Fujiyama H, Tsuji T, Hironaka K, Yoshida K, Sugimoto N, Fujita M Abstract GRWD1 functions as a histone chaperone to promote loading of the MCM replication helicase at replication origins. GRWD1 is overexpressed in several cancer cell lines, and GRWD1 overexpression confers tumorigenic potential in human cells. However,...
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Related ArticlesPatient/Provider Discussions About Clinical Trial Participation and Reasons for Nonparticipation Among Adolescent and Young Adult Women with Cancer. J Adolesc Young Adult Oncol. 2019 Sep 23;: Authors: Anderson C, Smitherman AB, Meernik C, Edwards TP, Deal AM, Cannizzaro N, Baggett CD, Chao C, Nichols HB Abstract Purpose: Clinical trial enrollment is low among adolescents and young adults (AYAs) with cancer and may contribute to inferior...
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Related ArticlesUsefulness of combination with both continuous administration of hypoxic cytotoxin and mild temperature hyperthermia in boron neutron capture therapy in terms of local tumor response and lung metastatic potential. Int J Radiat Biol. 2019 Sep 23;:1-10 Authors: Masunaga SI, Sakurai Y, Tanaka H, Takata T, Suzuki M, Sanada Y, Tano K, Maruhashi A, Ono K Abstract Purpose: To evaluate the usefulness of combined treatment with both continuous...
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Related ArticlesStructural validation of facial skin using optical coherence tomography: A descriptive study. Skin Res Technol. 2019 Sep 23;: Authors: Jerjes W, Hamdoon Z, Hopper C Abstract BACKGROUND: In this immediate ex vivo study, we aimed to identify the structures of normal and pathological facial skin using optical coherence tomography (OCT) and compared them to the gold standard histopathology. MATERIAL AND METHODS: A total of 53 patients,...
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Related ArticlesUveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019 Sep 23;: Authors: Matuskova V, Hornackova P, Uhmannova R, Zlamalikova L, Liskova K, Uher M, Vlkova E Abstract AIM: The aim of this cytogenetic study is to confirm the significance of chromosome 3 loss (monosomy 3) and of the gain of chromosome 8 as prognostic markers in histopathological samples...
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Related ArticlesMelanoma-derived exosomes induce reprogramming fibroblasts into cancer-associated fibroblasts via Gm26809 delivery. Cell Cycle. 2019 Sep 23;:1-10 Authors: Hu T, Hu J Abstract Cancer-associated fibroblasts (CAFs) are activated fibroblasts and can interact with cancer cells to promote tumor progression. The process of how tumor cells reprogram normal fibroblasts (NFs) to tumor-promoting CAFs regulated by long non-coding RNA (lncRNA) remains...
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Related ArticlesSynthesis and relaxometric characterization of new Poly[N,N-bis(3-AminoPropyl)Glycine] (PAPGly) dendrons Gd-based contrast agents and their in-vivo study by using the Dynamic Contrast-Enhanced MRI technique at Low field (1 T). Chem Biodivers. 2019 Sep 22;: Authors: Laurent S, Granato L, Longo D, Vander Elst L, Henoumont C, Aime S, Muller RN Abstract The synthesis of poly[N,N-bis(3-aminopropyl)glycine] (PAPGly) dendrons Gd-based contrast...
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Related ArticlesFollow the nevus: the cost-utility of monitoring for growth of choroidal nevi. Int J Ophthalmol. 2019;12(9):1456-1464 Authors: Barsam AS, Gibbons A, McClellan AJ, Harbour JW, Smiddy WE Abstract AIM: To develop a model to evaluate the cost-utility of choroidal nevi monitoring recommendations with varying clinical risk factors. METHODS: A Markov model was created to evaluate the cost-utility in cost per quality-adjusted life-year...
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Related ArticlesParaneoplastic opsoclonus-myoclonus syndrome secondary to melanoma metastasis form occult primary cancer. Case Rep Neurol. 2019 Jan-Apr;11(1):66-79 Authors: Mondragón JD, Jiménez-Zarazúa O, Vélez-Ramírez LN, Martínez-Rivera MA, Enríquez-Maciel S, González-Guzmán J, Alvarez-Delgado MM, González-Carrillo PL Abstract Introduction: Opsoclonus-myoclonus syndrome (OMS) is an inflammatory neurological disorder, often requiring a prompt medical...
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