Abstract The incidence of melanoma in situ (MIS) is increasing more rapidly than this of invasive,1. According to SEER database it represents one of the most fast‐growing malignancies2. Reported data from South Europe mostly include information from Italy and Spain3. We tried to study the epidemiological trends of MIS in Greece.
21h
Abstract Epidermodysplasia verruciformis (EV), a rare dermatologic condition, was first described by Lewandosky and Lutz in 1922. Subsequently, the disease was linked to nonsense mutations in EVER1 and EVER2 which were proposed to enhance susceptibility to EV‐specific β‐human papillomavirus (HPV) subtypes. However, genetic alterations alone did not adequately explain the propensity for EV to arise in immunocompromised patients, especially those who are human immunodeficiency virus (HIV)‐positive...
21h
Abstract Background Long‐term efficacy and safety of ixekizumab (160 mg at Week 0, then 80 mg every 2 weeks [Q2W] for 12 weeks, followed by every 4 weeks [Q4W] thereafter [i.e., Q2W/Q4W], which is the labeled psoriasis dosing where approved, except in Japan) has been established for the treatment of adults with moderate‐to‐severe plaque psoriasis. However, some patients may benefit from remaining on Q2W dosing beyond 12 weeks. Methods Among patients who had sPGA>1 at Week 12, efficacy...
21h
Abstract Warts are benign neoplasms of the skin and mucosa caused by human papillomavirus (HPV) infection.1 The most common treatments for wart are topical application of salicylic acid and cryotherapy. Other modalities include chemical agents, contact sensitizing agents and surgical excision.2 Laser modalities, including carbon dioxide (CO2), pulsed dye and neodymium‐doped: yttrium‐aluminum‐garnet lasers, have also been used to treat recalcitrant plantar warts.
21h
Abstract Post‐Traumatic Stress Disorder (PTSD) can develop when an individual has an experience that threatens their psychological or physical integrity.1 PTSD has been observed in patients with sudden‐onset, life‐altering or life‐threatening health conditions ranging from cancer and asthma2,3 to Stevens‐Johnson Syndrome,4 but has not been evaluated in chronic, relapsing inflammatory dermatologic diseases such as autoimmune bullous disease. PTSD may also directly impact immune function and a wide...
21h
Abstract Background Basal cell carcinomas (BCCs) exhibit aberrant activation of the hedgehog pathway. Sonidegib is a hedgehog pathway inhibitor approved for the treatment of locally advanced BCC (laBCC) and metastatic BCC (mBCC) based on primary results of the BOLT (Basal Cell Carcinoma Outcomes with LDE225 [sonidegib] Treatment) study. Purpose This is the final 42‐month analysis of the BOLT study evaluating sonidegib efficacy and safety. Methods Adults with no prior hedgehog pathway...
21h
Abstract Purpose Success rate in replantation/revascularization digital surgery is one of the challenges of reconstructive surgery. For this reason, investigating prognostic factors for survival and improvement of outcomes is highly relevant. The goal of this study was to establish predictive factors of survival in replantation/revascularization digital surgery. Methods ...
21h
Abstract Differentiation antagonizing non‐protein coding RNA (DANCR) is a newly identified oncogenic long noncoding RNA found in various cancers. However, the functional role of DANCR in tumor angiogenesis and the underlying mechanisms are still unclear. The expression of DANCR was determined in ovarian malignant tissues and cell lines. The functional role of DANCR in tumor angiogenesis was revealed by the following methods: CD31 staining of ovarian tumor tissues, matrigel‐plug assay tissues, HUVEC‐related...
21h
Abstract Syndecan‐1 (CD138) is a transmembrane proteoglycan expressed in normal and malignant tissues. It is of interest because of a possible prognostic effect in tumors and as a target for Indatuximab, a monoclonal antibody coupled to a cytotoxic agent. To assess the prognostic role of CD138 expression in breast cancer (BCa), a tissue microarray containing 1535 BCa specimens was analyzed by immunohistochemistry. Cytoplasmic, membranous, and stromal CD138 staining was separately analyzed. In normal...
21h
Abstract Cell manipulation plays a vital role in the success rate and efficiency of the cell microsurgical operations, including biopsy of cell internal organelles such as the embryo biopsy, in which the embryo is manipulated and reoriented safely to a predefined desired position and orientation. In this paper, a simplified approach for the blastocyst embryo reorientation is proposed. It utilizes conventional tools and techniques currently in use in manual approaches in research...
21h
Background: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma represents an important subgroup of head and neck cancer, but HPV occurs also in the less common neuroendocrine carcinomas (NEC). The PD-1/PD-L1 pathway appears to be activated in pulmonary NEC and correlates with a higher mutation burden, but the potential of NEC to respond to checkpoint inhibitors is unknown to a large extent. Objectives: To determine the HPV status of NEC of the head and neck region and to investigate...
21h
We appreciate the comments of Zhang and colleagues in their Letter to the Editor about our recent work “Impact of Neoadjuvant Chemotherapy on the Postoperative Outcomes of Patients Undergoing Liver Resection for Colorectal Liver Metastases: A Population Based Propensity-Matched Analysis."1 In their letter, Zhang and colleagues raised several questions about the selection of covariates for propensity score matching in our study. Specifically, the authors recommended matching all variables (including...
21h
We read with great interest the recent study reported by Wiseman and colleagues.1 Through propensity score matching (PSM) analysis of 3,779 patients, the authors evaluated the impact of neoadjuvant chemotherapy before hepatectomy on postoperative complications in colorectal cancer patients with liver metastases (CRLMs). We appreciated this work, which specified the safety of earlier neoadjuvant chemotherapy of CRLMs receiving hepatectomy. However, we would like to raise the following concerns: First,...
21h
In a recent issue of the Journal, Turner and colleagues1 described how, after their hospital was identified as an American College of Surgeons NSQIP outlier for Clostridium difficile (C difficile) infection, a series of interventions was associated with a substantial reduction in C difficile infection over the next year. The article is well written and there is no question that Dr Turner's hospital put a lot of time and effort into quality improvement. But because this article does not contemplate...
21h
We would like to thank Sauaia and colleagues1 for their thoughtful commentary on our article, “Wounding Patterns Based on Firearm Type in Civilian Public Mass Shootings in the United States.” We wholeheartedly agree with the points raised by these authors. As noted in our article, our inability to obtain autopsy results on all of the events, and the fact that we did not have information on firearm type for the events for which we had autopsy results are key limitations of the article. We therefore...
21h
Get credit right away by taking all CME tests online http://jacscme.facs.org
21h
We read with interest the recent publication by Luckett and colleagues, “Use of Hepatitis C Virus Antibody-Positive Donor Livers in Hepatitis C Nonviremic Liver Transplant Recipients,”1 which outlined their important work on this topic. As a high-volume liver transplant program in United Network for Organ Sharing region 5, which has the highest mean Model for End-Stage Liver Disease score at transplantation of any region of the US, we are acutely aware of the shortage of donor organs and how critical...
21h
We read with interest the article titled, “Cholecystectomy during the third trimester of pregnancy: proceed or delay?” by Fong and colleagues.1 The authors should be congratulated; their article addresses an important issue: gallbladder disease during pregnancy, which poses a management dilemma for surgeons and patients alike. Using the California Office of Statewide Health Planning and Development database, the authors identified all women undergoing cholecystectomy during the third trimester of...
21h
We thank Pearl and colleagues1 for their interest in our article titled, “Cholecystectomy during the third trimester of pregnancy: proceed or delay?” First, we would like to acknowledge and thank the authors for their role in the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) Guidelines Committee. These efforts are time consuming and costly, and these surgeons should be commended for taking on the necessary task of providing practitioners with guidelines to assist with everyday...
21h
Background gammadelta (γδ) T cells play important roles in allergic lower airway inflammation. However, little is known about their infiltration pattern in the nasal mucosa during upper airway inflammation. This study investigated γδ T cell distribution in nasal tissues of allergic rhinitis (AR) patients and the relationship between γδ T cells and other inflammatory cell types. Methods A total of 30 patients with septal deviation were examined, including 22 with and 8 without AR. The localization...
21h
Background The mechanisms underlying mucosal eosinophilia in chronic rhinosinusitis with nasal polyps (CRSwNP) remain poorly clarified. The nervous system and neuropeptides play an important role in the regulation of immune response. Herein we explore the expression and function of hemokinin‐1 (HK‐1), a newly identified tachykinin, along with its receptor neurokinin 1 receptor (NK1R) in CRSwNP. Methods HK‐1, NK1R, and C‐C motif chemokine ligand 24 (CCL24) expression in nasal tissues (53 eosinophilic...
21h
Splenic metastases are rare and usually occur in cases of disseminated disease. We report a case of a patient who had isolated splenic metastases with a previous history of left nephrectomy due to a renal cell carcinoma 11 years before. The aim of this report is to describe the case and review the literature of isolated splenic metastases due to renal carcinoma. This case emphasizes the importance of considering splenic metastatic disease even after many years of diagnosis of renal cell carcinoma.
21h
Abstract Our comprehensive cohort of 1100 unrelated achromatopsia (ACHM) patients comprises a considerable number of cases (~5%) harboring only a single pathogenic variant in the major ACHM gene CNGB3. We sequenced the entire CNGB3 locus in 33 of these patients in order to find a second variant which eventually explained the patients’ phenotype. Forty‐seven intronic CNGB3 variants were identified in 28 subjects after a filtering step based on frequency and the exclusion of variants found in cis...
21h
Abstract Expression of vascular endothelial growth factor A (VEGFA) is increased in chronic inflammatory skin diseases including psoriasis and loci for two VEGFA single nucleotide polymorphisms, are associated with early‐onset psoriasis (presenting before age 40 years). Studies have suggested that expression of placenta growth factor (PGF) is also up‐regulated in cutaneous inflammation and that VEGFA‐mediated angiogenesis may be dependent on the simultaneous presence of PGF within the skin. To...
21h
Abstract Purpose Radiomic features, clinical and dosimetric factors have the potential to predict radiation-induced toxicity. The aim of this study was to develop prediction models of radiotherapy-induced toxicities in prostate cancer patients based on computed tomography (CT) radiomics, clinical and dosimetric parameters. Methods In this prospective study, prostate...
21h
Abstract The finding of an effective cure or treatment for neurodegenerative diseases is one of the biggest challenges for this century. Although these diseases show different clinical manifestations, the presence of toxic protein aggregates in the brain of patients is a common feature to all of them, suggesting a loss of protein homeostasis. Aging, the primary risk factor for the majority of neurodegenerative disorders, is linked to the impairment of degradative compartments such as lysosomes and...
21h
We examined the effects of different components involved in the BioLuminescent‐Optogenetic (BL‐OG) on neural activity in vivo. We found a large dynamic range in which Coelenterazine (CTZ) elicits robust and specific effects, and a systematic relationship between CTZ, bioluminescence, and spiking activity. These data show that BL‐OG is a viable and selective method for modulating neural activity in vivo. Abstract BioLuminescent (BL) light production can modulate neural activity and behavior through...
21h
Purpose: The aim of this study was to develop an exercise protocol to improve maximal mouth opening (MMO), tongue protrusion (Tprot), tongue strength (Tstren), and lip strength (Lstren), and to assess its effects on subjects with scleroderma. Methods: We performed four replicated single-system studies in a consecutive sample of subjects with scleroderma. An instrumented assessment measured MMO, Tprot, Tstren, and Lstren. Each day, subjects were assessed and performed orofacial exercises conducted...
21h
The past few decades have seen rapid changes in speech-language pathology in terms of technology, information on speech production and perception, and increasing levels of multilingualism in communities. This tutorial provides an overview of phonetic transcription for the modern world, both for work with clients, and for research and training. The authors draw on their backgrounds in phonetics, phonology and speech-language pathology, and their crosslinguistic project in the phonological acquisition...
21h
AbstractThe medial frontal cortex is important for goal-directed behaviours such as visual search. The pre-supplementary motor area (pre-SMA) plays a critical role in linking higher-level goals to actions, but little is known about the responses of individual cells in this area in humans. Pre-SMA dysfunction is thought to be a critical factor in the cognitive deficits that are observed in diseases such as Parkinson’s disease and schizophrenia, making it important to develop a better mechanistic understanding...
22h
BackgroundAmbulance services across the UK have recognised a clinical and operational problem with persistent high users of the 999 service, but there is a lack of evidence about what works in this setting and how. We aim to evaluate the effectiveness, safety and efficiency of multi-agency case management approaches to the care of people who frequently call the emergency ambulance service, and gain understanding of barriers and facilitators to implementation. MethodsWe will carry out a mixed methods...
22h
The incidence of pressure ulcers or injuries is a global healthcare issue and in the top six most common adverse events in healthcare. Pressure injuries also are symptomatic of wider system failure and poor care. Recognition of these injuries and prevention strategies must start in the emergency department. This article will detail best practice in relation to both assessment of these injuries and their prevention in the emergency department.
22h
BackgroundPre-hospital research around the experience of transgender and non-binary (TNB) patients is scarce, with existing articles lacking input from TNB patients. This research aimed to collate TNB patients’ experiences of interacting with the ambulance service. A secondary aim was to gather TNB patients’ opinions regarding the education of ambulance clinicians on TNB health issues. MethodAn online-based, mixed-methods survey was created. A range of free text, multiple choice and Likert-scaled...
22h
ObjectiveThis study determined the impact of the caller’s emotional state and cooperation on out-of-hospital cardiac arrest (OHCA) recognition and dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) performance metrics. MethodsThis was a retrospective study using data from November 2015 to October 2016 from the emergency medical service dispatching centre in northern Taiwan. Audio recordings of callers contacting the centre regarding adult patients with non-traumatic OHCA were reviewed. The...
22h
BackgroundOpioids account for more fatalities by overdose than any other drug. Fatal opioid overdose is a growing public health problem, with incidence rising in western countries especially. We sought to describe the deaths, sociodemographic characteristics, and service usage patterns of decedents of opioid overdose in Wales. MethodsWe carried out a retrospective cross-sectional analysis of opioid related deaths in Wales identified from Office for National Statistics data between 01/01/2012 and...
22h
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