IJERPH, Vol. 16, Pages 3456: Effect of Same-Sex Marriage Referendums on the Suicidal Ideation Rate among Nonheterosexual People in Taiwan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183456 Authors: Lin Ko Huang Chen Lu Yen : Taiwan held voter-initiated referendums to determine same-sex marriage legalization on 24 November 2018. This study aims to compare suicidal ideation rates in heterosexual and nonheterosexual participants...
IJERPH, Vol. 16, Pages 3458: Impacts of Climate Change on Outdoor Workers and their Safety: Some Research Priorities International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183458 Authors: Moda Filho Minhas The literature on the potential impacts of climate change on the health of outdoor workers has received limited attention as a whole, and in sub-Saharan African countries in particular. Yet, substantial numbers of workers are experiencing the...
IJERPH, Vol. 16, Pages 3455: Spatial and Temporal Variation of PM10 from Industrial Point Sources in a Rural Area in Limpopo, South Africa International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183455 Authors: Cheledi E. Tshehla Caradee Y. Wright Air pollution from industrial point sources accounts for a large proportion of air pollution issues affecting many communities around the world. However, emissions from these sources are technically controllable...
IJERPH, Vol. 16, Pages 3453: Prospective Application of Palm Oil Mill Boiler Ash as a Biosorbent: Effect of Microwave Irradiation and Palm Oil Mill Effluent Decolorization by Adsorption International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183453 Authors: Muhammad Hazwan Hamzah Muhammad Fitri Ahmad Asri Hasfalina Che Man Abdulsalam Mohammed Common conventional biological treatment methods fail to decolorize palm oil mill effluent (POME). The...
IJERPH, Vol. 16, Pages 3452: Dynamic Changes of NDVI in the Growing Season of the Tibetan Plateau During the Past 17 Years and Its Response to Climate Change International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183452 Authors: Xianglin Huang Tingbin Zhang Guihua Yi Dong He Xiaobing Zhou Jingji Li Xiaojuan Bie Jiaqing Miao The fragile alpine vegetation in the Tibetan Plateau (TP) is very sensitive to environmental changes, making...
IJERPH, Vol. 16, Pages 3454: Analysis of Epidemiological Characteristics of Scarlet Fever in Zhejiang Province, China, 2004–2018 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183454 Authors: Qinbao Lu Haocheng Wu Zheyuan Ding Chen Wu Junfen Lin Objective: The aim of this study was to analyze the trends and epidemiological characteristics of scarlet fever in Zhejiang Province in 2004–2018, intending to provide a basis for...
IJERPH, Vol. 16, Pages 3450: New Eye Lens Dose Limit: Status of Knowledge in Campania Hospitals International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183450 Authors: Vittoria D’Avino Leopoldo Angrisani Giuseppe La Verde Mariagabriella Pugliese Adelaide Raulo Giuseppe Sabatino Fulvio Coppola The International Commission on Radiation Protection (ICRP) in 2011 recommended the lowering of the annual eye lens dose limit from 150 mSv/year...
IJERPH, Vol. 16, Pages 3449: Identifying the Factors Related to Depressive Symptoms Amongst Community-Dwelling Older Adults with Mild Cognitive Impairment International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183449 Authors: Dan Song Doris S.F. Yu Polly W.C. Li Qiuhua Sun High-level depressive symptoms have been reported in individuals with mild cognitive impairment (MCI), resulting in increased risk of progression to dementia. However, studies...
IJERPH, Vol. 16, Pages 3451: Move-It: A Cluster-Randomised Digital Worksite Exercise Intervention in China: Outcome and Process Evaluation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183451 Authors: Holly Blake Betsy Lai Emil Coman Jonathan Houdmont Amanda Griffiths We evaluate the outcomes and processes of a video and web-based worksite exercise intervention for sedentary office workers in China, in a 2-arm cluster-randomised wait-list...
IJERPH, Vol. 16, Pages 3448: Newborn Health Indicators Associated with Maternal Age during First Pregnancy International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183448 Authors: Leticia Molina-García Manuel Hidalgo-Ruiz Ana María Cámara-Jurado Maria Jose Fernández-Valero Miguel Delgado-Rodríguez Juan Miguel Martínez-Galiano Delaying motherhood is becoming increasingly common, raising questions of the possible influence that maternal age...
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IJMS, Vol. 20, Pages 4613: A Novel Effector Protein of Apple Proliferation Phytoplasma Disrupts Cell Integrity of Nicotiana spp. Protoplasts International Journal of Molecular Sciences doi: 10.3390/ijms20184613 Authors: Cecilia Mittelberger Hagen Stellmach Bettina Hause Christine Kerschbamer Katja Schlink Thomas Letschka Katrin Janik Effector proteins play an important role in the virulence of plant pathogens such as phytoplasma, which are the causative agents of hundreds...
IJMS, Vol. 20, Pages 4612: Application of the SwissDrugDesign Online Resources in Virtual Screening International Journal of Molecular Sciences doi: 10.3390/ijms20184612 Authors: Antoine Daina Vincent Zoete SwissDrugDesign is an important initiative led by the Molecular Modeling Group of the SIB Swiss Institute of Bioinformatics. This project provides a collection of freely available online tools for computer-aided drug design. Some of these web-based methods, i.e., SwissSimilarity...
IJMS, Vol. 20, Pages 4611: Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis International Journal of Molecular Sciences doi: 10.3390/ijms20184611 Authors: David L. Newman Stephen L. Gregory Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between...
IJMS, Vol. 20, Pages 4610: Proteomic Analysis in Morquio A Cells Treated with Immobilized Enzymatic Replacement Therapy on Nanostructured Lipid Systems International Journal of Molecular Sciences doi: 10.3390/ijms20184610 Authors: J. Víctor Álvarez Susana B. Bravo María García-Vence María J. De Castro Asteria Luzardo Cristóbal Colón Shunji Tomatsu Francisco J. Otero-Espinar María L. Couce Morquio A syndrome, or mucopolysaccharidosis type IVA (MPS IVA), is a lysosomal...
IJMS, Vol. 20, Pages 4608: Genetically Encoded Photosensitizers as Light-Triggered Antimicrobial Agents International Journal of Molecular Sciences doi: 10.3390/ijms20184608 Authors: Fabienne Hilgers Nora Lisa Bitzenhofer Yannic Ackermann Alina Burmeister Alexander Grünberger Karl-Erich Jaeger Thomas Drepper Diseases caused by multi-drug resistant pathogens have become a global concern. Therefore, new approaches suitable for treating these bacteria are urgently needed....
IJMS, Vol. 20, Pages 4606: Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20184606 Authors: Rodríguez Castaño Parween Pandey Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric is rich in curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin....
IJMS, Vol. 20, Pages 4607: PKCδ Mediates NF-κB Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms20184607 Authors: Lee Kim Lee Kwon The precise mechanism of hepatic cirrhosis remains largely unclear. In particular, a potential regulatory mechanism by which protein kinase C-delta (PKCδ ) affects profibrogenic gene expression involved in hepatic cirrhosis has never been explored....
IJMS, Vol. 20, Pages 4604: Effects of the Hydrophilic–Lipophilic Balance of Alternating Peptides on Self-Assembly and Thermo-Responsive Behaviors International Journal of Molecular Sciences doi: 10.3390/ijms20184604 Authors: Ihsan Nargis Koyama A series of N-substituted poly(Gly–alter–Val) peptides were successfully synthesized for the systematic evaluation of the micellization behavior of alternating peptides. Three-component polymerization employing an...
IJMS, Vol. 20, Pages 4605: 46,XX DSD due to Androgen Excess in Monogenic Disorders of Steroidogenesis: Genetic, Biochemical, and Clinical Features International Journal of Molecular Sciences doi: 10.3390/ijms20184605 Authors: Baronio Ortolano Menabò Cassio Baldazzi Di Natale Tonti Vestrucci Balsamo The term ‘differences of sex development’ (DSD) refers to a group of congenital conditions that are associated with atypical development...
IJMS, Vol. 20, Pages 4609: Rare Human Missense Variants can affect the Function of Disease-Relevant Proteins by Loss and Gain of Peroxisomal Targeting Motifs International Journal of Molecular Sciences doi: 10.3390/ijms20184609 Authors: Chong Kunze Hochreiter Krenn Berger Maurer-Stroh Single nucleotide variants (SNVs) resulting in amino acid substitutions (i.e., missense variants) can affect protein localization by changing or creating new targeting signals. Here,...
IJMS, Vol. 20, Pages 4602: Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity International Journal of Molecular Sciences doi: 10.3390/ijms20184602 Authors: Nemeikaitė-Čėnienė Šarlauskas Jonušienė Marozienė Misevičienė Yantsevich Čėnas Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN→O) exhibit promising antibacterial, antiprotozoal, and tumoricidal activities. Their...
IJMS, Vol. 20, Pages 4603: Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184603 Authors: Ohneda Ohmori Yamamoto Mast cell tryptases have crucial roles in allergic and inflammatory diseases. The mouse tryptase genes represent a cluster of loci on chromosome 16p3.3. While their functional studies have been extensively performed, transcriptional regulation...
IJMS, Vol. 20, Pages 4600: Exosomal MiRNAs in Pediatric Cancers International Journal of Molecular Sciences doi: 10.3390/ijms20184600 Authors: Angela Galardi Marta Colletti Virginia Di Paolo Patrizia Vitullo Loretta Antonetti Ida Russo Angela Di Giannatale MicroRNAs (miRNAs) have generated great attention in oncology as they play a fundamental role in the regulation of gene expression and their aberrant expression is present in almost all types of tumors including pediatric...
IJMS, Vol. 20, Pages 4601: Urinary Neuropilin-1: A Predictive Biomarker for Renal Outcome in Lupus Nephritis International Journal of Molecular Sciences doi: 10.3390/ijms20184601 Authors: Torres-Salido Sanchis Solé Moliné Vidal Vidal Solà Hotter Ordi-Ros Cortés-Hernández At present, Lupus Nephritis (LN) is still awaiting a biomarker to better monitor disease activity, guide clinical treatment, and predict a patient’s long-term outcome. In...
IJMS, Vol. 20, Pages 4599: PTX3 Modulates Neovascularization and Immune Inflammatory Infiltrate in a Murine Model of Fibrosarcoma International Journal of Molecular Sciences doi: 10.3390/ijms20184599 Authors: Tiziana Annese Roberto Ronca Roberto Tamma Arianna Giacomini Simona Ruggieri Elisabetta Grillo Marco Presta Domenico Ribatti Fibrosarcoma is an aggressive subtype of soft tissue sarcoma categorized in infantile/congenital-type and adult-type. Fibrosarcoma cells...
IJMS, Vol. 20, Pages 4598: Effect of Central Injection of Neostigmine on the Bacterial Endotoxin Induced Suppression of GnRH/LH Secretion in Ewes during the Follicular Phase of the Estrous Cycle International Journal of Molecular Sciences doi: 10.3390/ijms20184598 Authors: Andrzej Przemysław Herman Janina Skipor Agata Krawczyńska Joanna Bochenek Karolina Wojtulewicz Bartosz Pawlina Hanna Antushevich Anna Herman Dorota Tomaszewska-Zaremba Induced by a bacterial...
IJMS, Vol. 20, Pages 4595: Development of Immortalized Human Tumor Endothelial Cells from Renal Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20184595 Authors: Nako Maishi Hiroshi Kikuchi Masumi Sato Hiroko Nagao-Kitamoto Dorcas A. Annan Shogo Baba Takayuki Hojo Misa Yanagiya Yusuke Ohba Genichiro Ishii Kenkichi Masutomi Nobuo Shinohara Yasuhiro Hida Kyoko Hida Tumor angiogenesis research and antiangiogenic drug development...
IJMS, Vol. 20, Pages 4596: Freezing–Thawing Procedures Remodel the Proteome of Ram Sperm before and after In Vitro Capacitation International Journal of Molecular Sciences doi: 10.3390/ijms20184596 Authors: Patricia Peris-Frau Alicia Martín-Maestro María Iniesta-Cuerda Irene Sánchez-Ajofrín Lourdes Mateos-Hernández J. Julián Garde Margarita Villar Ana Josefa Soler Mammalian sperm must undergo a set of structural and functional changes collectively termed as capacitation...
IJMS, Vol. 20, Pages 4597: Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications International Journal of Molecular Sciences doi: 10.3390/ijms20184597 Authors: Sharon Eleuteri Alessandra Fierabracci Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can be easily isolated and expanded in vitro. Despite being a powerful tool for clinical applications, they present limitations in terms of delivery, safety, and variability...
IJMS, Vol. 20, Pages 4594: Sequence and Structural Analysis of AA9 and AA10 LPMOs: An Insight into the Basis of Substrate Specificity and Regioselectivity International Journal of Molecular Sciences doi: 10.3390/ijms20184594 Authors: Xiaoli Zhou Xiaohua Qi Hongxia Huang Honghui Zhu Lytic polysaccharide monooxygenases (LPMOs) are key enzymes in both the natural carbon cycle and the biorefinery industry. Understanding the molecular basis of LPMOs acting on polysaccharide substrates...
IJMS, Vol. 20, Pages 4593: Identification and Expression Analysis of GRAS Transcription Factors to Elucidate Candidate Genes Related to Stolons, Fruit Ripening and Abiotic Stresses in Woodland Strawberry (Fragaria vesca) International Journal of Molecular Sciences doi: 10.3390/ijms20184593 Authors: Hong Chen Huihui Li Xiaoqing Lu Longzheng Chen Jing Liu Han Wu The cultivated strawberry (Fragaria × ananassa), an allo-octoploid with non-climacteric fleshy fruits,...
IJMS, Vol. 20, Pages 4592: The Second Life of Methylarginines as Cardiovascular Targets International Journal of Molecular Sciences doi: 10.3390/ijms20184592 Authors: Natalia Jarzebska Arduino A. Mangoni Jens Martens-Lobenhoffer Stefanie M. Bode-Böger Roman N. Rodionov Endogenous methylarginines were proposed as cardiovascular risk factors more than two decades ago, however, so far, this knowledge has not led to the development of novel therapeutic approaches. The initial...
IJMS, Vol. 20, Pages 4591: Roles of the INO80 and SWR1 Chromatin Remodeling Complexes in Plants International Journal of Molecular Sciences doi: 10.3390/ijms20184591 Authors: Jianhao Wang Sujuan Gao Xiuling Peng Keqiang Wu Songguang Yang Eukaryotic genes are packed into a dynamic but stable nucleoprotein structure called chromatin. Chromatin-remodeling and modifying complexes generate a dynamic chromatin environment that ensures appropriate DNA processing and metabolism in...
IJMS, Vol. 20, Pages 4589: Specialist and Generalist Fungal Parasites Induce Distinct Biochemical Changes in the Mandible Muscles of Their Host International Journal of Molecular Sciences doi: 10.3390/ijms20184589 Authors: Shanshan Zheng Raquel Loreto Philip Smith Andrew Patterson David Hughes Liande Wang Some parasites have evolved the ability to adaptively manipulate host behavior. One notable example is the fungus Ophiocordyceps unilateralis sensu lato, which has evolved...
IJMS, Vol. 20, Pages 4590: PGE1-Containing Protocols Generate Mature (Leukemia-Derived) Dendritic Cells Directly from Leukemic Whole Blood International Journal of Molecular Sciences doi: 10.3390/ijms20184590 Authors: Daniel Christoph Amberger Fatemeh Doraneh-Gard Carina Gunsilius Melanie Weinmann Sabine Möbius Christoph Kugler Nicole Rogers Corinna Böck Uwe Ködel Jan-Ole Werner Doris Krämer Britta Eiz-Vesper Andreas Rank Christoph Schmid Helga Maria...
IJMS, Vol. 20, Pages 4588: Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion International Journal of Molecular Sciences doi: 10.3390/ijms20184588 Authors: Eman A. Taha Kisho Ono Takanori Eguchi Extracellular heat shock proteins (ex-HSPs) have been found in exosomes, oncosomes, membrane surfaces, as well as free HSP in cancer and various pathological conditions, also known as alarmins. Such ex-HSPs include HSP90 (α, β, Gp96,...
IJMS, Vol. 20, Pages 4585: A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics International Journal of Molecular Sciences doi: 10.3390/ijms20184585 Authors: Nikolai Genov Stefano Castellana Felix Scholkmann Daniele Capocefalo Mauro Truglio Jessica Rosati Elisa Maria Turco Tommaso Biagini Annalucia Carbone Tommaso Mazza Angela Relógio Gianluigi Mazzoccoli Cellular, organ, and whole animal physiology show temporal variation...
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JCM, Vol. 8, Pages 1480: Association between Achievement of Estimated Average Glucose Level and 6-Month Neurologic Outcome in Comatose Cardiac Arrest Survivors: A Propensity Score-Matched Analysis Journal of Clinical Medicine doi: 10.3390/jcm8091480 Authors: Yong Hun Jung Byung Kook Lee Kyung Woon Jeung Dong Hun Lee Hyoung Youn Lee Yong Soo Cho Chun Song Youn Jung Soo Park Yong II Min We investigated whether achieving estimated average glucose (EAG) levels versus...
JCM, Vol. 8, Pages 1479: Disseminated Well-Differentiated Gastro-Entero-Pancreatic Tumors Are Associated with Metabolic Syndrome Journal of Clinical Medicine doi: 10.3390/jcm8091479 Authors: Santos Castro Antunes Henrique Cardoso Monteiro The association of well-differentiated gastro-entero-pancreatic neuroendocrine tumors (WD GEP-NETs) with metabolic syndrome (MetS), abdominal obesity, and fasting glucose abnormalities was recently described. The aim of this study...
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