1 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
2 Audiology Institute, Department of Audiology and Speech-Language Pathology, Hallym University of Graduate Studies, Seoul, Korea.,,Soree Ear Clinic, Seoul, Korea.,Department of Head and Neck Surgery, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.,1 Laboratory of Peroxisomes & Lipid Metabolism, Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.,1
1 Department of Otolaryngology, Faculty of Medicine, Shimane University, Izumo city, Japan.
2 Department of Experimental Animals, Center for Integrated Research in Science, Shimane University, Izumo city, Japan.
3 Department of Otorhinolaryngology, University of Crete, School of Medicine, Crete, Greece.,
1 Oregon Hearing Research Center, Department of Otolaryngology-Head & Neck Surgery, OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA.
2 Sartorius-Stedim North America, Arvada, CO, USA.
3 OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA.,
1 Baylor University, Waco, TX, USA.
2 Texas Tech University Health Sciences Center School of Health Professions, Lubbock, TX, USA.
3 University of Texas-Austin, Austin, TX, USA.
4 University of Texas at Dallas School of Behavioral and Brain Sciences, Callier Center for Communication Disorders, Richardson, TX, USA.
5 Vanderbilt University, Nashville, TN, USA.
6 University of Texas at Dallas Erik Jonsson School of Engineering and Computer Science, Richardson, TX, USA.,1 Department of Otorhinolaryngology, Showa University, Shinjuku-ku, Tokyo, Japan.
2 Product Support Department, Carl Zeiss Microscopy Co. Ltd., Shinjuku-ku, Tokyo, Japan.
3 Department of Otolaryngology, Ebara Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo, Japan.
4 Department of Molecular Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.,
2 Department of Obstetrics and Gynecology, Iksan Hospital, Jeonbuk, Korea.
3 Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.,Department of Otorhinolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.1 Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
2 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,1 Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
2 Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,,1 Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
2 Department of Radiology, Ajou University School of Medicine, Suwon, Republic of Korea.,1
1 Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
2 Department of Integrative Biology & Physiology, UCLA, Los Angeles, CA, USA.
3 Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,
1 Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
2 The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.,
Department of Otolaryngology, Faculty of Medicine, Oita University, Oita, Japan.
1 Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Kangnam Secred Heart Hospital, Seoul, Korea.
2 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea.
3 Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Cheonan, Korea.
1 University of Iowa, Iowa City, IA, USA.
2 Johns Hopkins University, Baltimore, MD, USA.
1 Department of Ophthalmology, Division of Glaucoma, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
2 Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
3 Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
4 Robotic Surgery Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
5 Department of Otolaryngology-Head and Neck Surgery, Division of Sleep Surgery, Rush University Medical Center, Chicago, Illinois, USA.
6 Department of Otolaryngology, Advanced Center for Specialty Care, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.
7 Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
8 Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
2 Audiology Institute, Department of Audiology and Speech-Language Pathology, Hallym University of Graduate Studies, Seoul, Korea.,,Soree Ear Clinic, Seoul, Korea.,Department of Head and Neck Surgery, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.,1 Laboratory of Peroxisomes & Lipid Metabolism, Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.,1
1 Department of Otolaryngology, Faculty of Medicine, Shimane University, Izumo city, Japan.
2 Department of Experimental Animals, Center for Integrated Research in Science, Shimane University, Izumo city, Japan.
3 Department of Otorhinolaryngology, University of Crete, School of Medicine, Crete, Greece.,
1 Oregon Hearing Research Center, Department of Otolaryngology-Head & Neck Surgery, OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA.
2 Sartorius-Stedim North America, Arvada, CO, USA.
3 OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA.,
1 Baylor University, Waco, TX, USA.
2 Texas Tech University Health Sciences Center School of Health Professions, Lubbock, TX, USA.
3 University of Texas-Austin, Austin, TX, USA.
4 University of Texas at Dallas School of Behavioral and Brain Sciences, Callier Center for Communication Disorders, Richardson, TX, USA.
5 Vanderbilt University, Nashville, TN, USA.
6 University of Texas at Dallas Erik Jonsson School of Engineering and Computer Science, Richardson, TX, USA.,1 Department of Otorhinolaryngology, Showa University, Shinjuku-ku, Tokyo, Japan.
2 Product Support Department, Carl Zeiss Microscopy Co. Ltd., Shinjuku-ku, Tokyo, Japan.
3 Department of Otolaryngology, Ebara Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo, Japan.
4 Department of Molecular Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.,
2 Department of Obstetrics and Gynecology, Iksan Hospital, Jeonbuk, Korea.
3 Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.,Department of Otorhinolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.1 Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
2 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,1 Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
2 Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,,1 Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
2 Department of Radiology, Ajou University School of Medicine, Suwon, Republic of Korea.,1
1 Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
2 Department of Integrative Biology & Physiology, UCLA, Los Angeles, CA, USA.
3 Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.,
1 Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
2 The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.,
Department of Otolaryngology, Faculty of Medicine, Oita University, Oita, Japan.
1 Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Kangnam Secred Heart Hospital, Seoul, Korea.
2 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea.
3 Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Cheonan, Korea.
1 University of Iowa, Iowa City, IA, USA.
2 Johns Hopkins University, Baltimore, MD, USA.
1 Department of Ophthalmology, Division of Glaucoma, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
2 Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
3 Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
4 Robotic Surgery Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
5 Department of Otolaryngology-Head and Neck Surgery, Division of Sleep Surgery, Rush University Medical Center, Chicago, Illinois, USA.
6 Department of Otolaryngology, Advanced Center for Specialty Care, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.
7 Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
8 Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Effects of OSA Surgery on Ophthalmological Microstructures.
Author information
- 1
- 1 Department of Ophthalmology, Division of Glaucoma, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
- 2
- 2 Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
- 3
- 3 Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
- 4
- 4 Robotic Surgery Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
- 5
- 5 Department of Otolaryngology-Head and Neck Surgery, Division of Sleep Surgery, Rush University Medical Center, Chicago, Illinois, USA.
- 6
- 6 Department of Otolaryngology, Advanced Center for Specialty Care, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.
- 7
- 7 Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
- 8
- 8 Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Abstract
OBJECTIVE:
Obstructive sleep apnea/hypopnea syndrome (OSA) could compromise oxygenation of the optic nerve and cause glaucomatous optic neuropathy; however, there were no studies to investigate the changes of visual function and retinal microstructures in OSA patients after upper airway surgery. We aim to assess the changes in the visual sensitivity and retinal fiber layer thickness in OSA patients before and after surgery.
METHODS:
This prospective single-blind study enrolled patients with OSA from a tertiary academic medical center who had unsuccessful conservative therapy and then underwent surgery. The patients were referred for comprehensive ophthalmologic evaluation at baseline and 6 months after OSA surgery. The polysomnographic findings were collected pre- and postoperatively. Visual sensitivities on standard automated perimetry (SAP) were assessed. Peripapillary retinal nerve fiber layer (RNFL) thickness and macular layer (ML) thickness parameters were measured by spectral-domain optical coherence tomography (OCT).
RESULTS:
A total of 108 OSA patients were enrolled. Six months after surgery, the major parameters of polysomnography (PSG), mean deviation, and pattern standard deviation of SAP significantly improved in these OSA patients. Regarding the OCT parameters, thickness of ML in the nasal-outer, superior-inner, temporal-inner, inferior-inner, nasal-inner sectors, and total ML thickness significantly increased 6 months after upper airway surgery in the severe OSA group (apnea/hypopnea index ⩾30 per hour).
CONCLUSION:
The visual sensitivities on SAP, ML thickness on OCT, and oxygenation status on PSG significantly improved 6 months after upper airway surgery in patients with severe OSA. Upper airway surgery may ameliorate the microstructures of the retina in patients with severe OSA.
KEYWORDS:
glaucoma; macular thickness; obstructive sleep apnea surgery; obstructive sleep apnea syndrome; retinal nerve fiber layer
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