Wall Contrast Enhancement of Thrombosed Intracranial Aneurysms at 7T MRI
T. Sato, T. Matsushige, B. Chen, O. Gembruch, P. Dammann, R. Jabbarli, M. Forsting, A. Junker, S. Maderwald, H.H. Quick, M.E. Ladd, U. Sure and K.H. Wrede
American Journal of Neuroradiology May 2019, DOI: https://doi.org/10.3174/ajnr.A6084
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Abstract
BACKGROUND AND PURPOSE: The pathophysiology of wall contrast enhancement in thrombosed intracranial aneurysms is incompletely understood. This in vivo study aimed to investigate wall microstructures with gadolinium-enhanced 7T MR imaging.
MATERIALS AND METHODS: Thirteen patients with 14 thrombosed intracranial aneurysms were evaluated using a 7T whole-body MR imaging system with nonenhanced and gadolinium-enhanced high-resolution MPRAGE. Tissue samples were available in 5 cases, and histopathologic findings were correlated with 7T MR imaging to identify the gadolinium-enhancing microstructures.
RESULTS: Partial or complete inner wall enhancement correlated with neovascularization of the inner wall layer and the adjacent thrombus. Additional partial or complete outer wall enhancement can be explained by formation of vasa vasorum in the outer aneurysm wall layer. The double-rim enhancement correlated with perifocal edema and wall histologic findings suggestive of instability.
CONCLUSIONS: Two distinct aneurysm wall microstructures responsible for gadolinium enhancement not depictable at lower spatial resolutions can be visualized in vivo using high-resolution gadolinium-enhanced 7T MR imaging.
Footnotes
Disclosures: Bixia Chen—RELATED: Grant: Programm zur internen Forschungsförderung Essen grant, Comments: scientific grant of the University of Duisburg-Essen.* Oliver Gembruch—RELATED: Grant: Interne Forschungsförderung Essen, Comments: The grant is a scientific grant given by the University Duisburg-Essen.* Harald H. Quick—RELATED: Other: Siemens Healthcare, Erlangen, Germany, Comments: The Erwin L. Hahn Institute for MR Imaging, University Duisburg-Essen, has an established research cooperation with Siemens Healthcare, Erlangen, Germany.* Karsten H. Wrede—RELATED: Grant: Programm zur internen Forschungsförderung Essen grant, Comments: grant for scientific work from the University Duisburg Essen.* *Money paid to the institution.
Karsten H. Wrede, Bixia Chen, and Oliver Gembruch were supported by the University Duisburg-Essen (Programm zur internen Forschungsförderung Essen).
© 2019 by American Journal of Neuroradiology
T. Sato, T. Matsushige, B. Chen, O. Gembruch, P. Dammann, R. Jabbarli, M. Forsting, A. Junker, S. Maderwald, H.H. Quick, M.E. Ladd, U. Sure and K.H. Wrede
American Journal of Neuroradiology May 2019, DOI: https://doi.org/10.3174/ajnr.A6084
ArticleFigures & DataInfo & MetricsReferences PDF
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Abstract
BACKGROUND AND PURPOSE: The pathophysiology of wall contrast enhancement in thrombosed intracranial aneurysms is incompletely understood. This in vivo study aimed to investigate wall microstructures with gadolinium-enhanced 7T MR imaging.
MATERIALS AND METHODS: Thirteen patients with 14 thrombosed intracranial aneurysms were evaluated using a 7T whole-body MR imaging system with nonenhanced and gadolinium-enhanced high-resolution MPRAGE. Tissue samples were available in 5 cases, and histopathologic findings were correlated with 7T MR imaging to identify the gadolinium-enhancing microstructures.
RESULTS: Partial or complete inner wall enhancement correlated with neovascularization of the inner wall layer and the adjacent thrombus. Additional partial or complete outer wall enhancement can be explained by formation of vasa vasorum in the outer aneurysm wall layer. The double-rim enhancement correlated with perifocal edema and wall histologic findings suggestive of instability.
CONCLUSIONS: Two distinct aneurysm wall microstructures responsible for gadolinium enhancement not depictable at lower spatial resolutions can be visualized in vivo using high-resolution gadolinium-enhanced 7T MR imaging.
Footnotes
Disclosures: Bixia Chen—RELATED: Grant: Programm zur internen Forschungsförderung Essen grant, Comments: scientific grant of the University of Duisburg-Essen.* Oliver Gembruch—RELATED: Grant: Interne Forschungsförderung Essen, Comments: The grant is a scientific grant given by the University Duisburg-Essen.* Harald H. Quick—RELATED: Other: Siemens Healthcare, Erlangen, Germany, Comments: The Erwin L. Hahn Institute for MR Imaging, University Duisburg-Essen, has an established research cooperation with Siemens Healthcare, Erlangen, Germany.* Karsten H. Wrede—RELATED: Grant: Programm zur internen Forschungsförderung Essen grant, Comments: grant for scientific work from the University Duisburg Essen.* *Money paid to the institution.
Karsten H. Wrede, Bixia Chen, and Oliver Gembruch were supported by the University Duisburg-Essen (Programm zur internen Forschungsförderung Essen).
© 2019 by American Journal of Neuroradiology
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