Παρασκευή, 31 Μαΐου 2019

Pembrolizumab-induced uveitis in a patient with metastatic urothelial carcinoma
Lo-Ho Chen, Jhe-Cyuan Guo

Journal of Cancer Research and Practice 2019 6(2):92-95

Immune checkpoint blockade, especially targeting the programmed cell death protein-1/programmed death-ligand 1 axis, has changed the paradigm of anticancer therapy in several cancer types. For urothelial carcinoma (UC), pembrolizumab is an immune checkpoint inhibitor approved by the US Food and Drug Administration for locally advanced or metastatic disease. The new anticancer modalities are complicated with immune-related adverse events (irAEs) which are significantly different from conventional treatment such as chemotherapy or targeted therapy. Herein, we present an 85-year-old man with metastatic UC who developed a rare kind of irAE, uveitis, under pembrolizumab therapy, who fortunately partially recovered with local and systemic steroids. 

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