Toll like receptors (TLRs) in response to human gut microbiota of Indian obese and lean individuals Tej Bahadur, Rama Chaudhry, Vishwa Deepak Bamola, Sonu K Agrawal, Pawan Malhotra, Alka M Chutani, Bijay R Mirdha, Bimal K Das, Rahul K Sharma, Chandan K Thakur Journal of Family Medicine and Primary Care 2019 8(5):1567-1570 Background: The rising incidence of obesity is one of the most serious public health issues in the developed as well as in developing countries like India. Obesity and overweight are most important risk factors for many chronic diseases, including cardiovascular diseases, diabetes and cancer. In this study the body mass index (BMI) cut off was taken as 18.5-22.9 kg/m2 for normal, 23.0-24.9 kg/m2 for Overweight and >25 kg/m2 for obese as per WHO recommendation for Asian Indians, which is different for developed and developing countries. Role of gut microbiota mediated immune response in the development of obesity has been studied but the literature on Indian population are lacking. Therefore, a study was conducted to determine Toll like receptors (TLRs) in response to human gut microbiota of Indian obese and lean individuals using viable colonocytes in a Non invasive technique and Flowcytometry. Methods: A total of 20 healthy volunteer (10 obese and 10 lean) were enrolled in the study as per inclusion and exclusion criteria. Viable colonocytes were isolated from fecal samples using a Non invasive technique (SCSR Method). Toll like receptors (TLRs) and immunoglobulin (IgA &IgG) receptor concentration were measured by standard Flowcytometry methods using specific fluorochrome conjugated antibodies. Results: Average TLR2 receptor concentration was significantly higher in obese (6.35 %) as compared to lean (2.9 %) (P = 0.01). TLR4 receptor concentration was 1.4 % in obese and 1.65 % in lean although the difference was not statistically significant (P = 0.59). IgA & IgG receptor concentration was 49.6 % & 11.2 % in the obese and 67.15 % & 8.05 % in the lean respectively but the differences among both the group were not statistically significant. Conclusion: The results of the present study will be helpful for physicians and researchers to find some biomarkers which can determine predisposition of the obesity in Indian population and helps to use alternative therapeutics such as probiotics to maintain gut homeostasis and immune modulation to prevent obesity. |
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
Translate
Ετικέτες
Πέμπτη 30 Μαΐου 2019
Αναρτήθηκε από
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
στις
11:01 μ.μ.
Ετικέτες
00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(278)
- ► Φεβρουαρίου (139)
- ► Ιανουαρίου (139)
-
►
2022
(1962)
- ► Δεκεμβρίου (107)
- ► Σεπτεμβρίου (158)
- ► Φεβρουαρίου (165)
- ► Ιανουαρίου (163)
-
►
2021
(3614)
- ► Δεκεμβρίου (152)
- ► Σεπτεμβρίου (271)
- ► Φεβρουαρίου (64)
- ► Ιανουαρίου (357)
-
►
2020
(3279)
- ► Δεκεμβρίου (396)
- ► Σεπτεμβρίου (157)
- ► Φεβρουαρίου (382)
- ► Ιανουαρίου (84)
-
▼
2019
(11718)
- ► Δεκεμβρίου (265)
- ► Σεπτεμβρίου (545)
-
▼
Μαΐου
(1970)
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Pulmonary pleomorphic carcinoma harboring epide...
- Cervical cancer with breast metastasisChing-Tin...
- Inflammatory Pseudotumor of the LiverTsen-Long ...
- Pembrolizumab-induced uveitis in a patient with...
- Detection of anaplastic lymphoma kinase gene re...
- A Patient with refractory metastatic germ cell ...
- Modulation of oxidative stress by doxorubicin l...
- Antiproliferative effect of oxidative stress in...
- High-intensity focused ultrasound for localized...
- Prevention and management catheter-associated uri...
- people suffering from special phobiasAlireza Sang...
- singing on the happiness of older peopleMaryam En...
- Modeling of cardiac function of patients with a...
- patients with spinal muscular atrophy ,Ali-Asghar...
- Effect of cognitive behavior therapy integrated w...
- Warning System Designed to Predict Severe Sepsis ...
- Neurologic Complications of Infective Endocardi...
- Myeloid-Derived Suppressor Cells Mediate Immunosu...
- Tumour Spheroids-on-a-Chip ,M Ibrahim Khot, Mark ...
- Cancer Research and Practice
- Nursing and Midwifery Sciences
- Critical Care Medicine
- Podcast: Being a Professional Musician with Bipola...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Adjuvant therapies in venous leg ulcer management...
- Pressure Ulcer Summit 2018: An Interdisciplinary ...
- Leukemia inhibitory factor promotes the regenerat...
- Toll like receptors (TLRs) in response to human...
- Evaluation of hypercalciuria in patients receiv...
- Cytochemical tests to investigate sperm DNA dam...
- Family Medicine and Primary Care
- IL‐17A is not a treatment target in progressiv...
- The next‐generation BET inhibitor, PLX51107, d...
- Otolaryngology & Head and Neck Surgery
- Tropical Medicine
- Treating the primary in metastatic prostate cance...
- Cytoreductive nephrectomy in metastatic kidney ...
- Treating advanced penile cancer: where do we st...
- Supplemental oxygen for the management of dyspn...
- Multidimensional measurement of breathlessness:...
- Interdisciplinary management of chronic breath...
- Supportive and Palliative Care
- Organ Transplantation
- Serum carcinoembryonic antigen to predict recurre...
- Precision medicine in the ageing world: The role ...
- Prognostic roles of microRNA 143 and microRNA 145...
- Elevated neutrophil to lymphocyte and platelet to...
- Associated measurement of fucosylated levels of A...
- Clinicopathological and prognostic significance o...
- β-Arrestin-1 expression and epithelial-to-mesench...
- Prognostic nomogram for patients with non-metasta...
- Clinicopathological and molecular differences in ...
- Performance of a MethyLight assay for methylated ...
- Cell-free microRNAs as non-invasive biomarkers in...
- Urinary markers in treatment monitoring of lung c...
- Circular RNA ABCB10 promotes tumor progression an...
- Predictive significance of CYFRA21-1, squamous ce...
- Clinical significance of tumor miR-21, miR-221, m...
- The serum level of CC chemokine ligand 18 correla...
- iTRAQ-based proteomics reveals SOD2 as a potentia...
- New and old biomarkers in the differential diagno...
- Prognostic markers affecting the early recurrence...
- Cancer registries - guardians of breast cancer bi...
- Automated Pupillometry Devices in Critically Il...
- Language Monitoring in Brain Surgery Under Gene...
- Subanesthetic Dose of Ketamine Improved CFA-ind...
- Defining a Taxonomy of Intracranial Hypertensio...
- Pain Anxiety as a Mechanism Linking Pain Severi...
- The Association Between Antenatal Maternal Self...
- Prenatal Practice Staff Perceptions of Three Su...
- Exploring the Effects of Vitamin D Supplementat...
- How Might Maternal Poverty Impact the Course of...
- Poverty and Excess Length of Hospital Stay in Neo...
- The Effect of Depth of Anesthesia on Hemodynam...
- Neurosurgical Anesthesiology
- Addiction Medicine
- Vehicle Collision : Blunt rupture of the myocardiu...
- Variability in international normalized ratio a...
- Promotility Agents For The Treatment Of Ileus I...
- Ketamine Infusion for Pain Control in Adult Pat...
- Resuscitative Endovascular Balloon Occlusion of...
- Trauma and Acute Care Surgery
- Unfractionated heparin attenuates histone-mediat...
- Wall Contrast Enhancement of Thrombosed Intracran...
- Assessment of Explicitly Stated Interval Change o...
- Deep Learning–Based Automatic Segmentation of Lum...
- Hazardous Materials
- Sugar Alternatives : Molasses,Raw Honey,Stevia,Xyl...
- The Hearing Journal
- Molecular markers used to guide treatment, assess ...
- Programmed death-ligand 1 (PD-L1) also known as cl...
- Anaplastic lymphoma kinase (ALK) also known as ALK...
- Proto-oncogene tyrosine-protein kinase ROS is an e...
- The KRAS gene provides instructions for making a p...
- Amplification, also known as the over-expression o...
- Mutations that lead to EGFR overexpression (known ...
- A BRCA mutation is a mutation in either of the BRC...
- BRAF is a human gene that encodes a protein called...
- Differences in the Intended Meaning of Congest...
- ► Φεβρουαρίου (1143)
- ► Ιανουαρίου (744)
-
►
2017
(2)
- ► Φεβρουαρίου (1)
- ► Ιανουαρίου (1)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου