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Πέμπτη 30 Μαΐου 2019

Cancer registries - guardians of breast cancer biomarker information: A systematic review
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Lena Voith von Voithenberg, Emanuele Crocetti, Carmen Martos, ...
First Published April 10, 2019 Research Article 
https://doi.org/10.1177/1724600819836097
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 Article has an altmetric score of 1   Open Access Creative Commons Attribution 4.0 License
Article Information
Article first published online: April 10, 2019
Received: July 16, 2018; Revisions received: January 24, 2019; Accepted: February 05, 2019
Lena Voith von Voithenberg, Emanuele Crocetti, Carmen Martos, Nadya Dimitrova, Francesco Giusti, Giorgia Randi, Roisin Rooney, Tadeusz Dyba, Manola Bettio, Raquel Negrão Carvalho
European Commission, Joint Research Centre (JRC), Ispra, Italy

Corresponding Author:

Lena Voith von Voithenberg, European Commission, Directorate-General Joint Research Centre, Via Enrico Fermi 2749, TP 127, I-21027 Ispra (VA), Italy. Email: lena.voithenberg@web.de
This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Abstract
Background:
Breast cancer is the most common cancer and the leading cause of cancer-related death in females, with a large societal and economic impact. Decisions regarding its treatment are largely affected by the categorization into different subtypes with hormone receptor status and HER2 status being the most important predictive factors. Other biological markers play an important role for prognostic and predictive reasons. The data collection and harmonization of cancer cases are performed by cancer registries whose collection of parameters largely differs, partially including results from biomarker testing.

Methods:
This systematic literature review consisting of a total of 729 reports determined whether information about biomarker testing in breast cancer cases is collected and published by cancer registries worldwide.

Results:
The number of publications using breast cancer biomarker data from registries steeply rose with the beginning of the 21st century and some hospital-based and population-based cancer registries reacted with immediate collection of biomarker data following the recommendation of clinical guidelines. For female breast cancer, biomarkers have achieved an essential clinical value and this review points to a steady increase in the collection of biomarker data by cancer registries during the last decade.

Conclusions:
In the future, recommendations for biomarker data collection and coding by cancer registries may be required to ensure harmonization and comparability of the data.

Keywords Biomarkers, cancer registries, breast cancer < disease sites, prognostic/predictive markers < markers, molecular markers
Introduction
Biomarkers generally measure biological states that are objectively determinable by experiments. Biomarkers can be used as indicators for normal biological processes, treatment response, or pathogenic processes. The definition of biomarkers in the context of cancer includes substances produced by the cancer cells themselves or by the body in response to the tumor. These substances range from macromolecules such as RNA, DNA, genetic mutations, or proteins to whole cells. To date, no biomarker is sufficiently specific for cancer screening purposes. However, they are used in diagnosis, prognosis, staging, subtype differentiation, or treatment response of different types of cancer. While the research and discovery of new biomarkers is ongoing, and a variety of new biomarkers can be found in clinical studies, the number of biomarkers for which a recommendation for testing is included in national and international guidelines is limited. In recent decades, the definition and clinical classification of female breast cancer (BC) (Supplementary Note (SN)1) has changed completely relying on the expression of biomarkers for subtype differentiation (SN2). The analysis of biomarkers such as estrogen receptor (ER) and progesterone receptor (PgR), overexpressed in about two-thirds of all BC cases, and human epidermal growth factor receptor 2 (HER2) are indispensable for systemic treatment decisions in BC cases.1 Therefore a number of national and international recommendations on the topic have been issued. The most recent clinical guidelines recommend testing of ER, PgR, and HER2 for all primary invasive BC cases and recurrent lesions.1 Furthermore, the guidelines have been extended to include testing of the prognostic biomarkers Ki-67, carcinoembryonic antigen (CEA), cancer antigens (CA) 15.3 and 27.29, urokinase plasminogen activator (uPA), plasminogen activator inhibitor 1 (PAI-1), and the use of multi-gene expression panels under certain circumstances.1

This review set out to investigate the extent to which biomarker data on BC are collected by cancer registries worldwide and how this information is analyzed and published. Generally, cancer registries collect and analyze detailed information about cancer cases, ranging from essential information to describe incidence and mortality to a larger number of variables including treatment, follow-up, or biomarker data. As recent publications have facilitated the collection of biomarker data by providing templates for biomarker testing in BC,2 the number of cancer registries collecting detailed information about biomarker status is expected to constantly increase.

Methods
The literature review (Figure A(1)) was performed following the guidelines for systematic review (PRISMA)3 and results were compared to national and international clinical BC guidelines (Supplementary Methods).

Results and discussion
Onset of the collection of BC biomarker data by cancer registries
Cancer registries are a valuable source of information to evaluate cancer burden in the population, plus cancer care quality and treatment effects in the real world. Their scope, with respect to the number and types of variables collected, may differ between countries, regions, and individual registries. We used this study to identify the data on biomarkers included in clinical guidelines for BC and collected by cancer registries. The review comprised 729 publications (Figure A(1)), with sample numbers ranging from 10 patients to 34 million patients (SN3; Figure A(2)). The first reports were published as early as 1984 (Figure 1(a)). A substantial increase in the number of publications using BC biomarker data collected by registries occurred at the beginning of the 21st century. The same trend was observed for hospital-based and population-based registries, which meant that the data were available immediately to population-based registries with minimal time delay (Figure A(3); Figure 1(b)). Our search string resulted in a higher number of publications with data from population-based cancer registries (578) compared to hospital-based registries (155). This may be explained by the better availability of the data from population-based cancer registries to the research environment, but it also may be affected by the search string itself as hospitals, which did not carry “registr*” in their name in the title, abstract, or keywords of an article, were not included in the analysis. An overview of the temporal distribution of publications from population-based cancer registries for individual countries is displayed in Figure A(4)). In summary, the onset of frequent biomarker data use collected by cancer registries for publication is around 2000, with a development paralleling the recommendations issued in clinical guidelines.


                        figure
                   
Figure 1. Temporal distribution of publications using biomarker data from breast cancer patients collected by cancer registries. (a) Temporal distribution of the total number of publications for the years 1984–2016. (b) Temporal distribution of publications for the individual biomarkers ER, PgR, and HER2 stratified by type of registry (upper graph: population-based cancer registries, lower graph: hospital-based cancer registries) for the years 1984–2016. The first time point of clinical recommendations for each of the biomarkers is shown as an arrow of the respective color.

Geographical distribution of biomarker data use from cancer registries
Geographically, more than half of the publications (449) used data from North America—more specifically the US (418) (Figure 2). The number of publications from Europe was around half of that of the US (214). A total of 73 studies used data from Asia, 26 from Australia and New Zealand, 9 from Africa, and 6 from Central and South America. The distribution of publications within Europe ranged from numbers down to zero for some Eastern European countries (a total of 3 publications) and up to 20–30 publications in countries from Northern (total of 79), Western (91), and Southern (41) Europe (Figure A(5)). Interestingly, the temporal distribution of the published biomarker data collected by cancer registries did not differ between North America and Europe (Figure A(6)). An overview of the registries found to publish biomarker data is shown in Supplementary Table A(1).


                        figure
                   
Figure 2. Geographical distribution of the origin of the data used in the publications (violet circles). When data from several countries were used in one publication, this publication was counted for every country individually. One publication using data from the European Group for Blood and Marrow Transplantation Registry was excluded from the geographical representation.

Several reasons—apart from the collection of biomarker data by registries, such as the language of publication—can lead to the discrepancy in the number of publications from different regions of the world. Additionally, the use of biomarkers in the clinics may differ although American and European clinical guidelines have similar approaches on biomarker use.

It is interesting to note that more than half of the US–American publications retrieved their data from a common data source, the Surveillance, Epidemiology, and End Results Program (SEER), which has been collecting data regarding the ER and PgR status since 1990.4 The establishment of a common database of European cancer data is thus expected to greatly facilitate studies at the European level, and will result in a multitude of publications as the success of the SEER database indicates.5,6

Appearance of different molecular biomarkers in cancer registry-derived publications
All biomarkers collected and used for publication by cancer registries were found in clinical guideline recommendations (SN4). A clear majority of publications (97%, 75%, and 35%) used ER, PgR, and HER2 data, respectively (Figure 3(a)). These receptors were the first ones to be recommended in national and international guidelines and are, up to this date, the only ones that are recommended for testing in all newly diagnosed BCs, and recurrent lesions, which may differ from the original tumor.7,8 Furthermore, the steep increase in the number of publications around the year 2000 was mainly influenced by publications using ER and PgR data (Figure 3(b)). Although the role of ER in BC has long been known,9 early biochemical testing of these receptors was only possible with large tissue sections, and routine ER and PgR testing could only be introduced upon the establishment of immunohistochemical (IHC) analysis.10 A first guideline discussing the promise of ER IHC testing was published by Hutter in 1990.11


                        figure
                   
Figure 3. Distribution of the publications by breast cancer biomarker. (a) Number of publications using data from the individual biomarkers ER, PgR, HER2, Ki-67, CEA, cancer antigens (CA) 15.3 and 27.29, BRCA1 and 2, p53, and gene expression assays. (b) Temporal distribution of publications using data from the individual biomarkers ER, PgR, HER2 (upper graph), Ki-67, CEA, CA15.3, CA27.29 (middle), BRCA1/2, p53, and gene expression assays (lower graph) for the years 1984–2016. The first time point of clinical recommendations and guidelines for the biomarkers in breast cancer patients is shown as an arrow of the respective color.

Biomarker testing for adjuvant treatment decisions was reported less frequently (Figure 3(a)). Ki-67 status was found in 3% of the publications only. A lack of standardization and comparability of Ki-67 testing results has been described,12-14 which makes a harmonized collection of Ki-67 data difficult, and may be one of the reasons that explains the low number of publications. CEA, CA15.3, or CA27.29 were found even less frequently (0.1%–0.2% of publications). A single value of these biomarkers is usually not expressive, and these biomarkers can be tested regularly to follow the treatment response or metastatic BC.15 These multiple tests make data collection more challenging for the registries. Surprisingly, we did not observe the use of uPA and PAI-1 data in any of the publications, although these biomarkers are recommended in clinical guidelines for adjuvant treatment decisions since 2005 and testing comes at low tissue requirements and costs.16 Multigene expression assays—such as the 21- or 70-gene recurrence score used for similar prognostic reasons and chemotherapy applications—on the other hand, were found by our literature search from 2015 onwards (1% of publications). Their use and cost effectiveness have been described in a large variety of publications.17-19 However, owing to the large number of different tests, their results may not be easily collected in a standard format by the cancer registries. Genetic testing of BRCA1, BRCA2, or p53 has been published by cancer registries since 2001 with a rise in the numbers of publications (3%, 2%, and 0.5%, respectively) from 2009 onwards.

When compared to national or international recommendations of these biomarkers in clinical guidelines, the immediate onset of the clinical use and data collection by the registries was visible as the difference between the first time of recommendation and the publication (Figure 3(b)). A closer investigation of the time between the recommendation and publications by hospital-based or population-based cancer registries showed that the biomarker data of the three most frequently tested markers ER, PgR, and HER2 were collected and used by hospital-based and population-based registries almost simultaneously after recommendation (Figure 1 (b)). In addition, a few reports of biomarker data collection were even found before statements of recommendations were published. This is especially prominent in hospital-based registries, where publications using ER and PgR data can be found as early as 1984, and first publications using HER2 data appeared in 2002.

Utilization of molecular biomarker status
Biomarker data are analyzed for a variety of purposes including patient characteristics, cancer risk, staging, diagnosis, or subtype differentiation (SN5). As expected from the frequency of use of the biomarkers ER, PgR, and HER2, the largest number of the reviewed publications utilized the biomarker information for subtype differentiation leading to prognostic and predictive decisions (Figure A(7)).

Conclusions
This literature review clearly shows that biomarker data of BC patients are collected and used for publication by cancer registries. As this review is taking into account only registries using their biomarker data for publication, the total number of cancer registries collecting such information might be underestimated. At the same time, biomarker data could be collected for specific studies only and therefore a publication may not always be associated with the routine collection of biomarker data. The temporal trend of biomarker collection and publication of results using registry data seems to closely follow the inclusion of recommendations for biomarker use in the clinical guidelines. Furthermore, although the proportion of BC cases with available information regarding the biomarkers ER, PgR, and HER2 is high owing to their predictive values, an accurate and complete collection by registries is required for research and public health studies.20 Howlader et al.,21 for example, determined that for 12% of the BC cases, information regarding these biomarkers was not available in the SEER 17 registry database. Additionally, it is necessary to consider the timeframe of biomarker collection; for example, HER2 data has only been collected by the SEER database since 2010.22 Furthermore, there is still a need for inter-clinical and inter-registry harmonization of the data;5 for example, the thresholds for positivity, which can be achieved by common registration and reporting guidelines. Considering the ongoing establishment of a European cancer database,23 such harmonization would facilitate the extension of the variable list to include biomarker status, thus extending the ongoing research in North America by a Europe-wide analysis of cancer cases with the possibility of using large sample sizes. Common guidelines on the collection of biomarker data by registries, a centralized collection, and harmonization will therefore lead to the better availability of the data to the research community enabling large scale real world data analyses.

Acknowledgements
We are grateful to Úna Cullinan from the Joint Research Centre library for patiently retrieving non-open access publications. We thank Pedrazzoli Paolo, Asterios Kasmiris, Eoin McGrath, and Alanna Mueller for their help in searching missing information.

Declaration of conflicting interest
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding
The author(s) received no financial support for the research, authorship, and/or publication of this article.

Supplemental material
Supplemental material for this article is available online.

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