Mesenchymal stromal cells (MSCs) secrete many soluble growth factors and have previously been shown to stimulate nerve regeneration. MSC seeded processed nerve allografts could potentially be a promising method for large segmental motor nerve injuries. Further progress in our understanding of how the functions of MSCs can be leveraged for peripheral nerve repair is required before clinical translation can be made. The present study therefore investigated whether interactions of adipose-derived MSCs with decellularized nerve allografts can improve gene- and protein expression of growth factors that may support nerve regeneration.
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