A possible explanation for the poor response to inhaled corticosteroids (ICS) in approximately 45% of asthmatic children1 may be the weak association between guideline-based criteria for asthma control and ongoing allergic airway inflammation,2, 3 which may, if unrecognized in asymptomatic patients, result in serious sequelae, including airway remodeling.4 Thus, assessing airway inflammation has the potential to provide additional information to guidelines alone, which could be clinically useful in managing asthma.
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