Long-term studies on the integration of acellular porcine dermis as an implant shell and the effect on capsular fibrosis around silicone implants in a rat model

Journal of Plastic, Reconstructive & Aes.. by I. Ludolph, J.s. Gruener, A. Weigan.. - 8h ago Preview

 
 
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Acellular dermal matrices have recently increasingly been used in alloplastic breast reconstruction with silicone breast implants. Among these, acellular porcine dermis (APD) is frequently applied, but long-term data on tissue integration and capsular fibrosis formation are still missing.Silicone prostheses with (group A) and without (group B) APD as an implant covering shell were implanted in male Lewis rats. At 3, 12, and 52 weeks after implantation, the constructs were explanted. Molecular biological and immunohistochemical analysis was performed afterwards.

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