Ionic liquid as antibacterial agent for an experimental orthodontic adhesive

Dental Materials - 12h ago Preview

 
 
• AUTO POST
 
• SAVE TO EVERNOTE

Publication date: Available online 23 May 2019

Source: Dental Materials

Author(s): Isadora Martini Garcia, Carolina Jung Ferreira, Virgínia Serra de Souza, Vicente Castelo Branco Leitune, Susana Maria Werner Samuel, Gabriela de Souza Balbinot, Amanda de Souza da Motta, Fernanda Visioli, Jackson Damiani Scholten, Fabrício Mezzomo Collares

Abstract

Objective

The aim of this study was to formulate and evaluate experimental orthodontic adhesives with different concentrations of 1-n-butyl-3-methylimidazoilium bis(trifluoromethanesulfonyl)imide (BMIM.NTf2).

Methods

The experimental orthodontic adhesives were formulated with methacrylate monomers, photoinitiators and silica colloidal. The ionic liquid BMIM.NTf2 was synthesized and characterized. BMIM.NTf2 was added at 5 (G5%), 10 (G10%) and 15 (G15%) wt.%. One group contained no BMIM.NTf2 to function as control (GCtrl). The adhesives were evaluated for polymerization kinetics, degree of conversion (DC), Knoop hardness and softening in solvent, ultimate tensile strength (UTS), shear bond strength (SBS), thermogravimetric analysis (TGA), antibacterial activity and cytotoxicity.

Results

BMI.NTf2 showed the characteristic chemical peaks. The polymerization kinetics were different among the groups. G10% and G15% showed higher DC (p < 0.05). G5% and GCtrl had no differences for softening in solvent (p > 0.05). There were no differences for UTS (p > 0.05) and SBS (p > 0.05). TGA showed one different peak for G15%. All groups with BMIM.NTf2 showed antibacterial activity compared to GCtrl (p < 0.05) without cytotoxicity (p > 0.05).

Significance

To reduce biofilm formation around brackets and to prevent demineralization at susceptible sites, materials have been developed with antibacterial properties. In this study, a new experimental orthodontic adhesive was formulated with an imidazolium ionic liquid (BMIM.NTf2) as antibacterial agent. The incorporation of 5 wt.% of ionic liquid decreased biofilm formation without affecting the physico-chemical properties and cytotoxicity of an experimental orthodontic resin.