Immunohistochemical analysis of class‐switched subtype of primary cutaneous marginal zone lymphoma in terms of inducible skin‐associated lymphoid tissue (iSALT)
Toshiaki Kogame  Tomoya Takegami  Tatsuhiro Sakai  Tatsuki Kataoka  Masahiro Hirata  Fatimah Mohammad Budair  Chiyuki Ueshima  Miho Matsui  Takashi Nomura  Kenji Kabashima
First published: 24 May 2019 https://doi.org/10.1111/jdv.15703
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Abstract
Primary cutaneous marginal zone lymphoma (PCMZL) is a type of B‐cell lymphoma which is also known as cutaneous mucosa‐associated lymphoid tissue (MALT) lymphoma, since PCMZL harbors analogous cytology to MALT, a tertiary lymphoid organ (TLO) in digestive tract. PCMZL has two subtypes, “class‐switched subtype” and “non‐class‐switched subtype”. The class‐switched subtype is marked by well‐circumscribed lymphoid follicles (LFs) with plasmacytic infiltration coupled with the expression of class‐switched immunoglobulin rather than IgM. The non‐class‐switched subtype is characterized by the unorganized infiltration of IgM‐expressing B‐cells. The class‐switched subtype is associated with a better prognosis of 99‐100% survival in 5 years.

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