Chondrosarcoma of the Jaw: A Retrospective Series

Oral Surgery, Oral Medicine, Oral Pathol.. - 3d ago Preview

 
 
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Publication date: Available online 24 May 2019

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Akram A Almansoori, Hui-Young Kim, Bongju Kim, Soung-Min Kim, Jong-Ho Lee

Abstract

Objectives

Low-grade chondrosarcoma presents with similar features to other benign lesions like chondroma and synovial chondromatosis, which increases the difficulty in reaching an accurate diagnosis preoperatively. Here, we retrospectively reviewed 10 chondrosarcoma cases and evaluated their diagnostic approaches and management modalities.

Study Design

Ten patients were involved in the current study. We evaluated their clinical features, initial diagnosis, histopathology subtype, immunohistological markers, final diagnosis, and treatment modalities.

Results

Most of the lesions were found in the mandible. Two cases were followed up for one month and four years, respectively, as benign lesions before malignant changes were detected. Regarding chondrosarcoma histopathology subtypes, six cases were conventional chondrosarcoma, while four cases were mesenchymal chondrosarcoma with aggressive behavior; three of these were associated with local recurrence and metastasis. The immunohistological markers showed no specificity for chondrosarcoma.

Conclusions

Distinction of low-grade chondrosarcoma, particularly in the temporomandibular joint, from benign lesions like chondroma or synovial chondromatosis remains difficult. Currently, the correlation between clinical, radiographic, and histological features accompanied by close follow-up is extremely important for patients diagnosed with chondrogenic lesions. Postoperative radiotherapy seems to be beneficial for patients with positive surgical margins.