Publication date: Available online 9 May 2019
Source: Journal of Oral and Maxillofacial Surgery
Author(s): Gustavo Jacobucci Farah, Gustavo Zanna Ferreira, Carolina Ferrairo Danieletto-Zanna, Caroline Resquetti Luppi, Willian Pecin Jacomacci
Abstract
Objective
The objective of this study was to evaluate the effectiveness a herbal drug (valerian) to control anxiety during mandibular third molar extraction in comparison with a reference benzodiazepine drug commonly employed in dental procedures (midazolam).
Material and Methods
Twenty anxious patients with an indication for bilateral extraction of mandibular third molars were selected. Patients received capsules containing valerian 100 mg or midazolam 15 mg orally 60 minutes before the procedures in a randomized, split-mouth, crossover design. Changes in physiological parameters (oxygen saturation, heart rate, blood pressure, and respiratory rate) were assessed at specific times during surgery, and patients responded a questionnaire after the surgeries. The data were analyzed with Wilcoxon and paired t test with a significance level of 5%.
Results
No statistically significant differences in oxygen saturation were observed, regardless of the drug used. However, the other physiological parameters were significantly lower when patients received midazolam in comparison with valerian. Somnolence was the most common side effect reported with both drugs.
Conclusions
Although midazolam was more effective in reducing the physiological parameters studied, valerian seemed to provide the comfort and relaxation required, with no sedation and less somnolence than midazolam, during third molar extraction. Further studies are necessary before valerian may be clinically recommended.
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