Allergy and Immunology

GATA2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in humans

JACI (AOP) by Avanti Desai, Kathryn Sowerwine, Yi.. - 8h ago Preview

 
 
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GATA2 deficient patients have a low prevalence of allergic disease resulting from impaired IgE-mediated mast cell activation; thus, GATA2 represents a novel therapeutic target for clinical allergy.

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Virus-specific T cell clonotypes may contribute to drug hypersensitivity reactions via heterologous immunity

JACI (AOP) by Coral-ann Almeida, Paula Van Miert,.. - 8h ago Preview

 
 
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We provide proof-of-principle evidence that pathogen-specific memory T cells can recognise drug altered peptide repertoire presented on autologous HLA. Results presented here may have major implications for the aetiology, prevention and management of drug HSR.

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A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis

JACI (AOP) by Mohammed F. Alosaimi, Michelle C. M.. - 8h ago Preview

 
 
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A novel STAT2 variant causing complete STAT2 protein abrogation presents with hemophagocytic lymphohistiocytosis (HLH). This is the first report of HLH in association with STAT2 deficiency.

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NLRP3 contributes to inflammation, pyroptosis, and mucin production in human airway epithelium upon rhinovirus infection

JACI (AOP) by Tao Liu, Yu Tao Zhou, Li Qiu Wang, .. - 8h ago Preview

 
 
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The mechanism underlying hRV-induced airway epithelial alteration is poorly understood. Modulation of the NLRP3 inflammasome could be a novel therapeutic approach to control the hRV-induced exacerbation of chronic airway inflammation.

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GATA2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in humans

Journal of Allergy and Clinical Immunolo.. - 12h ago Preview

 
 
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Publication date: Available online 15 May 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Avanti Desai, Kathryn Sowerwine, Yihui Liu, Monica G. Lawrence, Jack Chovanec, Amy P. Hsu, Michael P. O’Connell, Jiwon Kim, Lisa Boris, Nina Jones, Laura Wisch, Robin R. Eisch, Melody C. Carter, Hirsh D. Komarow, Christa Zerbe, Joshua D. Milner, Irina Maric, Xiaoping Sun, Chyi-Chia R. Lee, Ilker Tunc

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Virus-specific T cell clonotypes may contribute to drug hypersensitivity reactions via heterologous immunity

Journal of Allergy and Clinical Immunolo.. - 12h ago Preview

 
 
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Publication date: Available online 15 May 2019

Source: Journal of Allergy and Clinical Immunology

Author(s): Coral-Ann Almeida, Paula van Miert, Kane O’Driscoll, Yvonne M. Zoet, Abha Chopra, Campbell Witt, Mina John, Frans H.J. Claas, Lloyd J. D’Orsogna

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Standardization of the nasal cytology in the work-up of allergic rhinitis.

Allergy - 18h ago Preview

 
 
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Publication date: Available online 15 May 2019

Source: Annals of Allergy, Asthma & Immunology

Author(s): Giorgio Ciprandi, Michela Silvestri

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