68Ga-DOTA-Exendin PET-MRI Fusion Imaging in a Case of Insulinoma.

Sood A1, Basher RK1, Kang M2, Shukla J1, Behera A3, Walia R4, Nada R5, Mittal BR1, Bhattacharya A1.

Author information

1

From the Departments of Nuclear Medicine.

2

Radiodiagnosis.

3

General Surgery.

4

Endocrinology, and.

5

Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Persistent hyperinsulinemic hypoglycemia in adults is most commonly caused by insulinomas, which pose a diagnostic challenge to physicians, surgeons, and radiologists and require multimodality imaging for precise localization and staging. PET tracers such as F-FDOPA and glucagon-like peptide 1 receptor analogs have been used for imaging insulinomas. Glucagon-like peptide 1 receptor analogs have recently shown promising results in preoperative localization of these tumors, as all insulinomas express glucagon-like peptide 1 receptors. Ga-DOTA-Exendin PET and MRI done in the present case helped in precise localization and management of the culprit lesion, whereas contrast-enhanced CT and F-FDOPA PET failed to do so.

PMID:

 

31107750

 

DOI:

 

10.1097/RLU.0000000000002620

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