A Case of Switching from GnRH Agonist to Antagonist for Castration Resistant Prostate Cancer Control
GnRH antagonist and GnRH agonist are widely used as androgen deprivation therapy for metastatic prostate cancer. A previous report demonstrated that patients with PSA levels of #x3e;20 ng/mL using GnRH antagonists showed favorable outcomes in comparison to those using GnRH agonists. An 82-year old male patient with edema, a stony hard nodule on his prostate, and an initial PSA level of 6,717 ng/mL was referred to our hospital due to suspected prostate cancer. He received prostate needle biopsy and...
Tue Sep 17, 2019 17:39
Neurothekeoma (NTK) is a specific benign soft tissue tumor, typically involving the skin of the head and neck area as well as the upper part of the body in young age with female predominance. It has a typical lobular pattern of growth but often displays atypical features such as myxoid stroma or fascicular pattern, which makes the diagnosis more difficult and may necessitate the use of immunohistochemical staining to differentiate NTK from nerve sheath tumor. Ocular NTK in general is very rare with...
Tue Sep 17, 2019 17:40
Adenoid cystic carcinomas (ACCs) are malignant tumors that most often occur in the salivary glands and bronchi, with occurrence in the breast being rare. ACCs of the breast reportedly give rise to few lymph node metastases or distant metastases and have a favorable prognosis. A 56-year-old woman with a left breast mass identified by mammographic screening was examined at our institute. Breast ultrasound revealed a sharply marginated, hypoechoic mass 12.7 × 9.4 × 8.7 mm in size in the upper outer...
Tue Sep 17, 2019 17:40
Epithelioid hemangioma is an uncommon benign vascular neoplasm which can arise in bone. Resection is generally curative, but occasionally lesions recur and recurrence after surgery can be morbid and destructive. Recent case reports have described the effective use of oral propranolol to control recurrent epithelioid hemangioma of the orbit. We report the case of a 26 year old man with recurrent aggressive osseous epithelioid hemangioma in the pelvis of which has been controlled for over a year with...
Tue Sep 17, 2019 17:41
Prior to the advent of immune checkpoint inhibitors targeting PD-1/PD-L1 axis no drug demonstrated to improve survival or quality of life in the second-line treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). Nivolumab appear to have a clear clinical benefit for R/M-HNSCC, based on improved survival, good toxicity profile, reduction in symptoms and improvement in overall quality of life. This benefit seems to be greater for PD-L1 positive patients and independent...
Tue Sep 17, 2019 17:41
Australian researchers looking for a genetic lifeline to endangered hog deer species endemic to Pakistan, northern India and mainland southeast Asia have found widespread hybridization of the species in Victoria.
Tue Sep 17, 2019 17:04
RNA World is a fascinating theory but it may not hold true. The problem is that the ingredients, such as enzymes, to make RNA World work just didn't exist on early Earth.
Tue Sep 17, 2019 18:54
ObjectiveTo assess the longitudinal associations of physical and psychosocial exposures with disability retirement due to a shoulder lesion.MethodsIn a nationwide register-based study, we followed 1 135 654 wage earners aged 30–59 years for the occurrence of disability retirement due to a shoulder lesion. The occupational exposures were assessed with job exposure matrices. We used a competing risk regression model to estimate HRs and their 95% CIs and to test for the association between the exposures...
Tue Sep 17, 2019 19:00
Zusammenfassung Adenome sind sehr seltene Tumoren des Mittelohres. Es handelt sich um benigne, von den Drüsenbestandteilen der Mittelohrschleimhaut ausgehende Neoplasien. Hyams und Michaels beschrieben erstmalig das Mitteladenomen, den sie als „adenomatöse Tumore“ bezeichneten im Jahr 1976. Wir berichten über eine 50-jährige Patientin, die sich mit seit einem Jahr bestehenden rezidivierenden rechtseitigen dumpfen Otalgien und pulssynchronen Tinnitus mit der Verdachtsdiagnose eines...
Tue Sep 17, 2019 03:00
Abstract Purpose The main aim of this study was to compare the efficacy of intratympanic administration of dexamethasone and resveratrol in preventing cisplatin ototoxicity by measuring acoustic brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Methods Forty rats (80 ears) were divided into five groups. Cisplatin was administered...
Tue Sep 17, 2019 03:00
Superior vestibular neuritis: improved detection using FLAIR sequence with delayed enhancement (1 h)
Abstract Introduction Vestibular neuritis is the second cause of vertigo and new imaging protocols using delayed FLAIR with double-dose of gadolinium are proposed for its diagnosis. Our aim is to demonstrate that a single dose of gadolinium is sufficient. Methods Thirty-three patients with a unilateral vestibular neuritis are compared to a control group....
Tue Sep 17, 2019 03:00
Abstract Purpose Surgical treatment is generally recommended for severe subglottic lesions following traumatic endotracheal intubation in children. An alternative approach is early transglottic corticosteroid administration to reduce scar formation and prevent the need for subsequent surgical intervention. This technique has been practiced successfully for several decades at the Children’s Hospital of Cologne and the outcomes of 26 subsequent...
Tue Sep 17, 2019 03:00
Abstract Despite widespread evidence that mating and intra‐sexual competition are costly, relatively little is known about how these costs dynamically change male and female phenotypes. Here, we test multiple hypotheses addressing this question in replicate flocks of red junglefowl (Gallus gallus). First, we test the inter‐relationships between social status, comb size (a fleshy ornament) and body mass at the onset of a mating trial. While comb size covaried positively with body mass across individuals...
Mon Sep 16, 2019 20:08
The adaptive value of epigenetic mutation: limited in large but high in small peripheral populations
Abstract The fate of populations during range expansions, invasions, and environmental changes is largely influenced by their ability to adapt to peripheral habitats. Recent models demonstrate that stable epigenetic modifications of gene expression that occur more frequently than genetic mutations can both help and hinder adaptation in panmictic populations. However, these models do not consider interactions between epimutations and evolutionary forces in peripheral populations. Here we use mainland‐island...
Tue Sep 17, 2019 15:12
Abstract Evolutionary theory predicts that females seek extra‐pair fertilisations from high‐quality males. In socially monogamous bird species, it is often old males that are most successful in extra‐pair fertilisations. Adaptive models of female extra‐pair mate choice suggest that old males may produce offspring of higher genetic quality than young males because they have proven their survivability. However, old males are also more likely to show signs of reproductive senescence, such as reduced...
Tue Sep 17, 2019 18:28
Abstract People can quickly detect bilateral reflection in an image. This is true when elements of the same luminance are matched on either side of the axis (symmetry) and when they have opposite luminance polarity (anti‐symmetry). Using EEG, we measured the well‐established Sustained Posterior Negativity (SPN) response to symmetry and anti‐symmetry. In one task, participants judged the presence or absence of regularity (Regularity Discrimination Task). In another, they judged the presence or absence...
Tue Sep 17, 2019 18:14
Abstract The main effectors in tumor control are the class I MHC molecule-restricted CD8+ cytotoxic T lymphocytes (CTLs). Tumor-specific CTL induction can be regulated by dendritic cells (DCs) expressing both tumor-derived epitopes and co-stimulatory molecules. Immunosuppressive tolerogenic DCs, having down-regulated co-stimulatory molecules, are seen within the tumor mass and can suppress tumor-specific CTL induction. The tolerogenic DCs expressing down-regulated XCR1+CD141+ appear...
Tue Sep 17, 2019 03:00
Abstract Trust may be important in shaping public attitudes to genetics and intentions to participate in genomics research and big data initiatives. As such, we examined trust in data sharing among the general public. A cross-sectional online survey collected responses from representative publics in the USA, Canada, UK and Australia (n = 8967). Participants were most likely to trust their medical doctor and less likely to trust other entities named. Company researchers were least...
Tue Sep 17, 2019 03:00
A reverse engineering system is employed to record and obtain detailed and comprehensive geometry data of vertebral endplates. Parametric models of vertebral endplate are then developed, which are beneficial to designing personalized spinal implants, making clinical diagnoses, and developing accurate finite element models.
Tue Sep 17, 2019 19:41
This paper demonstrates use of the gold standard method in behavioral genetics, the Cholesky decomposition method, to estimate unique, overlapping genetic and environmental influences on different variables to answer longitudinally motivated research questions.
Tue Sep 17, 2019 20:41
Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) is novel for the elimination of harmful antibodies. Here, we describe a detailed protocol for the synthesis of DCAF1 molecule, which can selectively block 4G2 antibody to eliminate antibody dependent enhancement effect during Dengue virus infection.
Tue Sep 17, 2019 20:41
Translating ribosome affinity purification (TRAP) enables rapid and efficient isolation of cell type-specific translating mRNA. Here, we demonstrate a method that combines hydrodynamic tail-vein injection in a mouse model of liver repopulation and TRAP to examine the expression profile of repopulating hepatocytes.
Tue Sep 17, 2019 21:42
We describe our protocol for measuring biological rhythms in protein catabolism via autophagy and the proteasome in mouse liver.
Tue Sep 17, 2019 21:42
Presented here is a protocol for enriching pachytene spermatocytes, round spermatids, and elongating spermatids from adult mouse testes using a discontinuous bovine serum albumin density gradient with standard laboratory equipment.
Tue Sep 17, 2019 22:44
Many of today’s smaller surgical clinics have to sterilize equipment in-house, and autoclave sensitive instruments are processed using ethylene oxide, a carcinogenic, explosive, and irritating gas. Gas plasma is another low temperature option, but it requires large and expensive equipment that doesn’t make sense for small practices. A new company called Plasmapp has developed small gas plasma sterilizers that are fast, affordable, and can be placed in any size clinic. Moreover, they...
Tue Sep 17, 2019 16:21
Siemens Healthineers won FDA clearance for the ARTIS icono angiography systems that are designed for use in a variety of procedure types. The ARTIS icono 2D/3D biplane system is intended for neuroradiology and abdominal imaging while the ARTIS icono floor has a single fluoroscope and is designed for vascular, interventional cardiology, surgical, and oncology procedures. Siemens touts its “OPTIQ image chain” implemented in the ARTIS icono, which supposedly “redesigns image processing for 2D...
Tue Sep 17, 2019 18:35
Ventrix, a spin-off company of the University of California San Diego, has developed a special hydrogel that can be injected into the heart to provide a platform for cardiac repair following a heart attack. The technology was just tested in humans for the first time as part of an FDA-approved Phase 1 clinical trial. Though limited in size, the study pointed to the safety of the hydrogel and there are definite signs that it helps to improve cardiac function. The hydrogel is produced from the...
Tue Sep 17, 2019 19:42
Biologics, being a group of drugs synthesized from biological sources, are often produced using bacteria. The manufacturing processes are usually slow and laborious, though they do benefit from economies of scale. Producing small quantities of biologics is typically limited to research labs, and even there it is limited in scope. Researchers at Duke University have now come up with an entirely new way to manufacture biologic drugs using engineered bacteria and tiny capsules. The bacteria,...
Tue Sep 17, 2019 22:43
Abstract The aim of the present study was to investigate and compare the surface deformations of different NiTi rotary files after retreatment under scanning electron microscope (SEM). A total of 240 upper central incisor teeth were obturated with vertical compaction technique and divided into 6 groups. Root canals were retreated by ProTaper Next (PTN), Twisted File Adaptive (TFA), Reciproc (RPC), ProTaper Universal Retreatment (PTR), R-Endo and Mtwo-R NiTi rotary systems. The...
Tue Sep 17, 2019 03:00
Abstract Bacterial colonization in the oral cavity is critical for efficient action of probiotics. However, limited colonization rates have been reported in many clinical trials. The aim of this pilot clinical study was to evaluate the colonization efficiency of Streptococcus dentisani under different dosing schedules and pre-treatment conditions. Eleven adult volunteers enrolled in the study. A professional ultrasound cleaning was performed in quadrants 1 and 4. The probiotic...
Tue Sep 17, 2019 03:00
Blunt, penetrating trauma to the ear, nose, and throat, and related structures are striking. Injuries may range from simple soft tissue wounds to complex injuries of the face, neck, and brain. Proximity of the cervical spine and airway complicate anesthetic management. A multidisciplinary approach is required. Airway control has highest priority in initial care. Management of airway, breathing, and circulation need to be tailored to the patient. Decisions regarding airway management, ventilation...
Tue Sep 17, 2019 03:00
Anesthesiologists and otolaryngologists share the airway in an elegant ballet that requires communication, collaboration, and mutual respect. This article addresses principles to prevent or manage challenging conditions such as airway fires, anatomically difficult airways, and post-tonsillectomy hemorrhage. Discussion includes rationales for the use of simulation and resilience engineering principles to achieve the safest patient care.
Tue Sep 17, 2019 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08018
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b02321
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09747
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05566
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07963
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07923
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06256
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07239
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06965
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06046
Tue Sep 17, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06276
Tue Sep 17, 2019 07:00
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