Defining three-dimensional (3D) normal craniofacial morphology in healthy children could provide craniofacial surgeons a reference point to assess disease, plan surgical reconstruction and evaluate treatment outcome. The purposes of this study were to report normal craniofacial form and quantify craniofacial asymmetry of healthy children in Taiwan by implementing 3D stereophotogrammetry technique.
7h
A plump single eyelid with medial epicanthal fold is the morphological feature of the Eastern Asian population. This study describes a practical technique that combines orbicularis oculi muscle resection based epicanthoplasty and orbicularis-tarsus fixation double eyelidplasty for cosmetic blepharoplasty, and reports on surgical outcomes in a large number of Chinese patients.
7h
Oncoplastic techniques have allowed surgeons to avoid deformity and obtain symmetry at the time of partial mastectomy without previous efforts at increasing breast size.1 Despite these successes, patients and surgeons have become increasingly demanding with regards to aesthetic outcomes. As such, we sought a way to safely augment and lift the breast in the same operative setting as the oncological resection. Here, we describe an approach that combines breast-conserving surgery with bilateral Wise-pattern...
7h
Although the complications of silicone implants and development of new materials have led to a decline in the use of silicone implants for orbital wall fractures, their usefulness is still reported. The overall incidence, risk factor, and treatment of silicone implant complications, especially those caused by cystic lesions, remain unclear. We aimed to report our experiences of patients with orbital wall fractures that were reconstructed with silicone implants and followed up for a long period.We...
7h
The use of povidone-iodine alone has been advocated by several authors who continued to utilize it for pocket irrigation despite the US Food and Drug Administration (FDA)’s prohibition of 2000. However, in 2017, the FDA removed the ban against povidone-iodine use in breast augmentation.In the practice of breast augmentation, pocket irrigation with various solutions has been advocated in preventing infection and capsular contraction. However, debate continues regarding an ideal solution that is most...
7h
Techniques based on three planes of implant placement, including the subglandular (SG), subpectoral (SP), and subfascial (SF) planes, are used for breast augmentation. The placement that offers the greatest balance of risks and benefits is unclear. This study presents a systematic review with a Bayesian network meta-analysis to compare different implant placement techniques for augmentation mammaplasty.
7h
Numerous advancements have been made in the surgical treatment of gynecomastia. However, one of the greatest challenges faced is the complete excision of the fibrous breast disc. We aim to review and compare the outcomes of the microdebrider excision and liposuction technique (MELT) with other techniques employed at our institution.
7h
In free tissue transfer, monitoring is paramount to timely detect vascular complications. While various technical methods have been introduced, clinical flap monitoring and here particularly capillary refill testing (CRT) remains the gold standard. In pale flaps, CRT is challenging as it relies on the color difference between blanched and perfused skin. We propose a new method of negative pressure induced hyperemia (NPIH) using handheld electrical negative pressure devices to improve flap monitoring.
7h
British Journal of Cancer, Published online: 25 September 2019; doi:10.1038/s41416-019-0580-9Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome
7h
British Journal of Cancer, Published online: 25 September 2019; doi:10.1038/s41416-019-0586-3Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy
7h
British Journal of Cancer, Published online: 24 September 2019; doi:10.1038/s41416-019-0591-6Correction: Desperately seeking…Models to find the right partner and the best use for checkpoint inhibitors
19h
British Journal of Cancer, Published online: 24 September 2019; doi:10.1038/s41416-019-0592-5Correction: Long-term outcomes of the GPOH NB97 trial for children with high-risk neuroblastoma comparing high-dose chemotherapy with autologous stem cell transplantation and oral chemotherapy as consolidation
19h
High Altitude Medicine &Biology, Volume 20, Issue 3, Page 279-292, September 2019.
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Abstract Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of the antimalarial drugs artemether and lumefantrine. Here we investigated the effect of CYP2B6*6 on the plasma pharmacokinetics of artemether, lumefantrine, and their metabolites in healthy volunteers. Thirty healthy and previously genotyped adult volunteers—15 noncarriers (CYP2B6*1/*1) and 15 homozygote carriers (CYP2B6*6/*6)—selected from a cohort of 150 subjects from the Ilorin metropolitan area were administered the complete...
8h
The “envirome” is a term which encompasses the overall environmental and extrinsic agents to which an individual is exposed, either constantly, seasonally or episodically. It has become increasingly recognized that such exposures may have significant impact on development of biological characteristics of an individual. This is especially notable in the development of allergic diseases. For example, the term “extrinsic asthma” refers to asthma driven by exposure to airborne allergens to which individuals...
8h
On a daily basis we, as emergency medicine providers, discuss drugs and their side effect profiles. We often survey our colleagues regarding rare reported phenomena that have not been previously encountered. In my short emergency medicine career, I've heard the praises of ketamine thousands of times over: “Ketamine is safe and effective.” “You can never give too much ketamine.” “You can theoretically get an emergence reaction, but I haven't seen it.” I will be the first to admit that I used ketamine...
8h
A healthy 36-year-old woman presented with onset of pelvic pain that began about 8 h prior to arrival in the emergency department (ED). She described the pain as cramping but intermittently sharp. It was throughout her pelvis and made worse with movement. The patient had no reported medical or surgical history. On initial evaluation, the patient's vital signs included a blood pressure of 122/78 mm/Hg and a heart rate of 76 beats/min. Remaining vital signs were unremarkable. The patient appeared uncomfortable...
8h
A 59-year-old man with a history of Graves' disease and diabetes presented to our emergency department with complaints of headache and vomiting. He had undergone surgical orbital decompression of his left eye for Graves' exophthalmos the previous day. On examination, the patient was somnolent with fixed-gaze palsy in his left eye. Pupils were reactive bilaterally. His vitals were unremarkable. The patient's computed tomography (CT) images are shown in Figures 1 and 2.
8h
The Internet is a universal source of information for parents of children with acute complaints.
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Abstract Oligodendrocyte progenitor cells (OPCs) account for about 5% of total brain and spinal cord cells, giving rise to myelinating oligodendrocytes that provide electrical insulation to neurons of the CNS. OPCs have also recently been shown to regulate inflammatory responses and glial scar formation, suggesting functions that extend beyond myelination. Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifaceted phagocytic receptor that is highly expressed in...
8h
Abstract The use of veterinary medical products and herbicides is a common practice in intensified livestock systems. These compounds affect nontarget organisms that perform important ecosystem functions, such as dung beetles. The assessment of body condition allows us to determine how individuals respond to changes in the environment. However, assessments of how contamination associated with cattle farming affects coprophagous insects such as dung beetles have not been conducted in natural systems....
8h
Abstract The OECD‐305 guidelines for bioaccumulation testing in fish include the option to conduct a dietary test for assessing a chemical's bioaccumulation behavior. However, the one‐compartment toxicokinetic model that is used in the guidelines to analyze the results from dietary bioaccumulation tests is not consistent with the current state of the science, experimental practices and information needs for bioaccumulation and risk assessment. This study presents (i) a two‐compartment toxicokinetic...
8h
Abstract Amphibians are declining worldwide, due in part to large‐scale degradation of habitat from agriculture and pervasive pathogens. Yet a common North American amphibian, the wood frog (Lithobates sylvaticus), ranges widely and persists in agricultural landscapes. Conventional survey techniques rely on visual encounters and dipnetting efforts, but detectability limits the ability to test for the effects of environmental variables on amphibian habitat suitability. Here, we used environmental...
8h
Nature Reviews Neurology, Published online: 24 September 2019; doi:10.1038/s41582-019-0271-4Trials take MS treatment forward
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Infertility has become a global health issue with the number of couples seeking in vitro fertilization (IVF) worldwide continuing to rise. Some couples remain childless after several IVF cycles. Women undergoi...
8h
Recently, numerous biological experiments have indicated that microRNAs (miRNAs) play critical roles in exploring the pathogenesis of various human diseases. Since traditional experimental methods for miRNA-di...
8h
To investigate the association of serum levels of 25(OH)D and 1,25(OH)2D3 in healthy and non-healthy controls with Crohn’s disease (CD) and ulcerative colitis (UC).
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Immunoglobulin A nephropathy (IgAN) is the leading cause of end-stage kidney disease. Previous mRNA microarray profiling studies of IgAN revealed inconsistent data. We sought to identify the aberrantly express...
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Advances in microRNAs (miRNAs) biomarkers have generated disease markers with potential clinical values. However, none of these published results have been applied in clinic until today. The main reason could ...
8h
Abstract The cattle tick, Rhipicephalus microplus, is a serious pest of cattle, with significant economic consequences to the livestock industries of tropical and semitropical countries. Rhipicephalus microplus belongs to the Metastriata group of the Ixodidae family known as hard ticks. When adult hard ticks feed, mating has not yet occurred and an initial host attachment phase of 1–2 days is followed by a slow feeding phase that can last several days. Once mating occurs, feeding...
8h
Abstract Leaf-dwelling mites often prefer to feed on young leaves and also are more likely to inhabit the abaxial leaf side. The aim of our study was to examine whether leaf age may affect production and distribution of eggs on black locust leaves by females of Aculops allotrichus. The eriophyoids were tested for 2.5 days on ‘trimmed’ compound leaves (with only two opposite leaflets left), which were maintained in vials filled with water. For the experiments we used leaves of three...
12h
Abstract Few studies have documented the indirect effects of predators on tick behavior. We conducted behavioral assays in the laboratory to quantify the effects of a highly abundant predator, the red imported fire ant (Solenopsis invicta), on three species of ticks endemic to the southern USA: the lone star tick (Amblyomma americanum), the Gulf Coast tick (A. maculatum), and the Cayenne tick (A. mixtum). We documented ant aggression toward ticks (biting, carrying, and stinging)...
12h
Abstract Dispersal of eriophyoid mites is crucial for the successful colonization of new plants. Literature suggests that their long-distance dispersal is through aerial transfer. During dispersal, eriophyoids might be captured in vapor or fine drops of water (perhaps most likely in clouds) where they might be protected against water loss and desiccation, but where they would have no food and be exposed to low temperatures and oxygen concentrations. Considerable resistance of these...
20h
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