A few studies have shown that esophageal air events (EAEs) such as air-swallows may be associated with symptoms that have historically been associated with gastroesophageal reflux disease (GERD). To objectively test a hypothesis that all EAE types (air swallows, supra-gastric belches and gastric belches) can be associated with GERD-like symptoms, we removed the impedance “tags” from the GER episodes (placed during autoscan) and instead tagged either air-swallows, supra-gastric belches or gastric...
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Background: Late preterm infants (born 34 to 36 weeks gestation) without cystic fibrosis (CF) are at risk for growth failure during the first two years of life. Infants with CF are at risk of being born premature and thus at risk for growth failure. The aim for this study was to assess weight-for-length (WFL) at two years of age for late preterm infants compared to term infants with CF. Methods: Data were collected from the U.S. CF Foundation Patient Registry. We compared growth parameters...
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BACKGROUND The appearance and symptoms of scars can cause significant distress to patients. OBJECTIVE To assess and compare efficacy of the 1,500-nm nonablative fractional laser (NAFL) and 10,600-nm ablative fractional laser (AFL) in reducing symptoms and improving the appearance of traumatic or surgical scars. MATERIALS AND METHODS Single-center prospective, randomized, blinded, split-scar study was conducted on 100 patients with a scar obtained through trauma or surgery. Three treatments...
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BACKGROUND Understanding the subjects' perspective is critical for successfully treating upper facial lines. OBJECTIVE To understand subjects' self-perception and overall satisfaction after onabotulinumtoxinA treatment for forehead and glabellar lines. METHODS This analysis pooled data from two 12-month, pivotal phase 3 studies in which toxin-naive subjects received onabotulinumtoxinA 40 U or placebo for treatment of upper facial lines. OnabotulinumtoxinA was administered as 0.1-mL injections...
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BACKGROUND Keloids have been assessed by numerous methods and severity indices resulting in a lack of standardization across published research. OBJECTIVE This study aims to evaluate published keloid randomized controlled trials (RCTs) and identify the need for a gold standard of assessment. METHODS and MATERIALS PubMed, MEDLINE, and Embase were searched for human RCTs on keloid treatment during a 10-year period. Eligible studies were English language RCTs reporting disease severity...
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BACKGROUND Pathologists sometimes include commentary on margin involvement in shave biopsy reports of keratinocyte carcinoma (KC). This practice can lead to confusion regarding the need for further treatment. There is limited literature evaluating the reliability of reported histologic margin status in shave biopsies of KC. OBJECTIVE To evaluate the negative predictive value (NPV) of reported clear shave biopsy margins in basal and squamous cell carcinomas to determine whether this assessment...
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Publication date: September 2019Source: Archives des Maladies Professionnelles et de l'Environnement, Volume 80, Issue 4Author(s):
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Publication date: September 2019Source: Archives des Maladies Professionnelles et de l'Environnement, Volume 80, Issue 4Author(s):
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Publication date: September 2019Source: Archives des Maladies Professionnelles et de l'Environnement, Volume 80, Issue 4Author(s):
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Publication date: September 2019Source: Archives des Maladies Professionnelles et de l'Environnement, Volume 80, Issue 4Author(s):
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This study was undertaken to determine the frequency, and the clinicopathologic and genetic features, of colon cancers driven by neurotrophic receptor tyrosine kinase (NTRK) gene fusions. Of the 7008 tumors screened for NTRK expression using a pan-Trk antibody, 16 (0.23%) had Trk immunoreactivity. ArcherDx assay detected TPM3-NTRK1 (n=9), LMNA-NTRK1 (n=3), TPR-NTRK1 (n=2) and EML4-NTRK3 (n=1) fusion transcripts in 15 cases with sufficient RNA quality. Patients were predominantly women (median age:...
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The pattern-based classification system of endocervical adenocarcinoma correlates with nodal metastasis and clinical outcomes, but its application in biopsies is challenging. The aim of this study was the correlation of additional histologic features with patterns of invasion as well as prognosis. A total of 103 specimens from 71 cervical adenocarcinoma cases were studied. Among the 71 cases, all had resection specimens including hysterectomy, cold knife cone excision or loop electrosurgical excision...
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Pneumocytic adenomyoepithelioma (PAM) was first described in 2007 and was included in the 2015 World Health Organization Classification of lung tumors as a variant of epithelial-myoepithelial tumor. This rare pulmonary neoplasm was reported to show both myoepithelial and duct-like components, with the latter exhibiting pneumocytic differentiation with TTF-1 expression. We present an index case and 6 additional retrospectively identified cases of pulmonary tumors with prototypical features of PAM....
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Publication date: Available online 24 September 2019Source: Neurobiology of AgingAuthor(s): Jun Yi Wang, David Hessl, Flora Tassone, Kyoungmi Kim, Randi J. Hagerman, Susan M. RiveraAbstractVentricular enlargement (VE) is commonly observed in aging and fragile X-associated tremor/ataxia syndrome (FXTAS), a late-onset neurodegenerative disorder. VE may generate a mechanical force causing structural deformation. In this longitudinal study, we examined the relationships between VE and structural changes...
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Publication date: Available online 24 September 2019Source: Neurobiology of AgingAuthor(s): Sarah Ryan, Eleanor Hobbs, Sara Rollinson, Stuart M. Pickering-BrownAbstractA C9orf72 repeat expansion is the most common cause of both frontotemporal dementia and motor neuron disease. The expansion is translated to produce dipeptide repeat proteins (DPRs), which are toxic in vivo and in vitro. However, the mechanisms underlying DPR toxicity remain unclear. Mouse models which express DPRs at repeat-lengths...
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Publication date: Available online 24 September 2019Source: Neurobiology of AgingAuthor(s): Shea J. Andrews, Brian Fulton-Howard, Christopher Patterson, G Peggy McFall, Alden Gross, Elias K. Michaelis, Alison Goate, Russell H. Swerdlow, Judy Pa, Alzheimer’s Disease Neuroimaging InitiativeAbstractWe examined the associations between mitochondrial DNA haplogroups (MT-hgs; mitochondrial haplotype groups defined by a specific combination of single nucleotide polymorphisms labeled as letters running from...
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Publication date: Available online 23 September 2019Source: Neurobiology of AgingAuthor(s): Foteini Christidi, Efstratios Karavasilis, Michail Rentzos, Georgios Velonakis, Vasiliki Zouvelou, Sofia Xirou, Georgios Argyropoulos, Ioannis Papatriantafyllou, Varvara Pantolewn, Panagiotis Ferentinos, Nikolaos Kelekis, Ioannis Seimenis, Ioannis Evdokimidis, Peter BedeAbstractWhile hippocampal involvement in ALS has been consistently highlighted by post-mortem studies, memory impairment remains under recognised...
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Publication date: Available online 23 September 2019Source: Neurobiology of AgingAuthor(s): Lucine Karanfilian, Maria Grazia Tosto, Karim MalkiAbstractAlzheimer’s Disease (AD) is a pervasive, neurodegenerative disorder and a major contributor to the global burden of disease. AD pathology includes amyloid plaque formation, tau hyperphosphorylation and neuroinflammation. Several genetic studies have identified a rare variant of TREM2 (Triggering Receptor Expressed on Myeloid cells 2) as a risk factor...
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Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Xiaoyun Chen, Xiaofeng Zhang, Jing Zhao, Xueyou Tang, Fengqin Wang, Huahua DuAbstractIron deficiency is the most common nutritional deficiency disorder in early postnatal period, which often manifesting into clinical complications. Therefore, iron supplementation is necessary to avoid iron deficiency anemia in the neonatal period. However, how to supplement iron effectively is a big problem. Thus, using...
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Publication date: December 2019Source: Biomedicine & Pharmacotherapy, Volume 120Author(s): Zhao Jin, Peipei Guo, Xinyi Li, Jianjuan Ke, Yanlin Wang, Huisheng WuAbstractIrisin, a 112-amino acid peptide induced with exercise in mice and human is thought to have correlation with the short-term outcomes of patients in ischemic stroke. In the present study, the neuroprotective effects of irisin were evaluated in vivo and in vitro and its underlying mechanism was also explored. The global cerebral...
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Abstract Introduction During surgery for lesions in eloquent areas the goal is to achieve the widest resection possible, without loss of neurological function. Intraoperative seizures may lead to abandonment of the procedure or damages to the patient. Awareness regarding the predictors of IOS would help the surgeon. The aim of this retrospective study was to identify the factors associated with the occurrence of IOS in patients who underwent...
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Abstract Purpose Information on predictive factors of cognitive functioning in patients with (multiple) brain metastases (BM) selected for radiosurgery may allow for more individual care and may play a role in predicting cognitive outcome after radiosurgery. The aim of this study was to evaluate cognitive performance, and predictors thereof, in patients with 1–10 BM before radiosurgery. ...
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Abstract Purpose Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) are noninvasive therapies for vestibular schwannomas providing excellent tumor control. However, delayed hearing loss after radiation therapy remains an issue. One potential target to for improving hearing rates is limiting radiation exposure to the cochlea. Methods ...
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AbstractIn recent years, the geographic information system (GIS) application has used the latest spatial data to help researchers make the right decisions in the shortest time. This study was conducted with the aim of using geographic information systems (ArcGIS) for selecting the best location for installing banners and billboards in a health campaign. This research was an analytical and applied research conducted in Sirjan city, Iran in 2018. In this research, GIS and fuzzy logic methods were used....
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AbstractThe purpose of this article is to describe the development of a theory-based, culturally and gender-relevant Community Health Worker (CWH)-led tobacco cessation intervention for low-income Brazilian women who augments the tobacco cessation program offered through the public health system using Intervention Mapping (IM). We began with the establishment of a network of representatives from different segments of society followed by comprehensive needs assessments. We then established a logical...
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AbstractLocal coalitions can advance public health initiative but have not been widely used or well-studied in low- and middle-income countries. This paper provides (i) an overview of an ongoing matched-pairs community-randomized controlled trial in 28 communities in Armenia and Georgia (N = 14/country) testing local coalitions to promote smoke-free policies/enforcement and (ii) characteristics of the communities involved. In July–August 2018, key informants (e.g. local public health center directors)...
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Abstract Purpose Torque control in lingual orthodontics is key to obtain optimal esthetic results. The aim of this in vitro experimental study was to verify the efficiency of the ligature–archwire–slot system in torque control using a customized lingual appliance. Methods An idealized cast with eight extracted human teeth was created and a set of customized...
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Zusammenfassung Ein präzises Lymphknoten(LK)-Staging ist in der onkologischen Chirurgie unerlässlich. Indocyaningrün(ICG)-gesteuerte Sentinel-Lymphknoten-Navigation mit Nahinfrarotfluoreszenz (NIRF) ist eine relativ neue Technik. Ziel dieses Artikels ist es, den Einfluss von ICG-NIRF auf die Identifikation von LK-Metastasen bei gastrointestinalen Tumoren zu analysieren. Es wurden die Literaturdatenbanken Scopus und PubMed/MEDLINE durchsucht und 20 Studien eingeschlossen. ICG-NIRF-LK-Navigation...
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Objectives: We report a case of a man with tamponade decompression syndrome following pericardial drainage. Data Sources: ICU - Montreal Heart Institute. Study Selection: Case report. Data Extraction: Clinical and surgical records. Data Synthesis None. Conclusions: Our case adds further concerns in supporting a patient with tamponade decompression syndrome, including mechanical circulatory support, due to the reversible nature of this condition. The authors have disclosed...
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Objectives: Vasopressin has achieved common usage for the treatment of catecholamine-requiring and catecholamine-resistant shock. Diabetes insipidus is a syndrome characterized by excretion of abnormally large volumes of dilute urine. To date, very few reports of diabetes insipidus after discontinuation of vasopressin infusion have been published; the majority of previous reports describe neurosurgical patients. The purpose of the present study was to investigate the occurrence rate of diabetes...
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Objective: Current international guidelines offer a conditional recommendation to consider a single dose of IV desmopressin (DDAVP) for antiplatelet-associated intracranial hemorrhage based on low-quality evidence. We provide the first comparative assessment analyzing DDAVP effectiveness and safety in antiplatelet-associated intracranial hemorrhage. Design: Retrospective chart review. Setting: Single tertiary care academic medical center. Patients: Adult patients taking at least...
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