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Thu Sep 12, 2019 03:00
Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
Background We have previously shown an embryonic stem cell (ESC)-like population within keloid-associated lymphoid tissues (KALTs) in keloid lesions (KLs) expresses components of the renin-angiotensin system (RAS) which maybe dysregulated. We hypothesized that cathepsin B (cathB), cathepsin D (cathD) and cathepsin G (cathG) are present within the ESC-like population in KLs and contribute to bypass loops of the RAS. Methods 3,3-Diaminobenzidine (DAB) immunohistochemical (IHC) staining for...
Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
Background: In 1984, Terzis reported on the potential use of a free platysma muscle transfer to reanimate the orbicularis oculi in long standing paralysis of this unit. However, the vascularized platysma flap proved difficult to transfer, and this technique is not widely used today. In the present study, we have described the technique involving grafting of the platysma muscle to restore eyelid function and retrospectively discussed its clinical outcomes. Methods: This retrospective analysis...
Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
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Thu Sep 12, 2019 03:00
Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our aim was to validate the prognostic significance of TRG in muscle-invasive bladder cancer in a multicenter setting. We enrolled 389 patients who underwent cisplatin-based chemotherapy before radical cystectomy in 8 centers between 2010 and 2016. Median...
Thu Sep 12, 2019 03:00
Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare and recently described entity associated with hereditary leiomyomatosis and RCC syndrome. FH-deficient RCC may show variable clinical and pathologic findings, but commonly presents with locally advanced and metastatic disease and carries a poor prognosis. We identified 32 patients with FH-deficient RCC, confirmed by FH immunohistochemistry (IHC) and/or FH mutation analysis, and performed a retrospective review of the clinical...
Thu Sep 12, 2019 03:00
Medaka (Oryzias sp.) is an important fish species in ecotoxicology and considered as a model species due to its biological features including small body size and short generation time. Since Japanese medaka Oryzias latipes is a freshwater species with access to an excellent genome resource, the marine medaka Oryzias melastigma is also applicable for the marine ecotoxicology. In genome era, a high-density genetic linkage map is a very useful resource in genomic research, providing a means for comparative...
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Since the autosomal genome is shared between the sexes, sex-specic fitness optima present an evolutionary challenge. While sexually antagonistic selection might favor different alleles within females and males, segregation randomly reassorts alleles at autosomal loci between sexes each generation. This process of homogenization during transmission thus prevents between-sex allelic divergence generated by sexually antagonistic selection from accumulating across multiple generations. However, recent...
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Uncovering how new members of multigene families acquire new functions is an important topic in evolutionary and developmental genetics. CORL proteins (SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to mammalian Sno/Ski oncogenes. Drosophila CORL (dCORL) participates in TGF-β and insulin signaling during development and in adult homeostasis but roles for the two mouse CORL proteins (mCORL) are essentially unknown. A series of studies were conducted...
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Signia has launched Signia Xperience, a new platform that introduces the world's first combination of advanced acoustic sensors with a built-in motion sensor. Signia Xperience hearing aids provide a complete analysis of the wearer's dynamic soundscape, allowing for automatic adjustments between sounds in front of and all around the wearer for a personalized listening experience. With YourSound technology, Signia Xperience hearing aids can identify more variables from the environment than ever before...
Tue Sep 17, 2019 16:27
Surgical Infections, Ahead of Print.
Tue Sep 17, 2019 10:00
Objectives In-stent restenosis (ISR) is one of the main long-term complications after coronary stent placement, and the ability to evaluate ISR noninvasively using coronary computed tomography (CT) angiography remains challenging. For this application, spectral photon-counting CT (SPCCT) has the potential to increase image quality and reduce artifacts due to its advanced detector technology. Our study aimed to verify the technical and clinical potential of a novel SPCCT prototype using an ISR...
Mon Sep 16, 2019 03:00
The advent of computed tomography (CT) has revolutionized radiology, and this revolution is still going on. Starting as a pure head scanner, modern CT systems are now able to perform whole-body examinations within a couple of seconds in isotropic resolution, single-rotation whole-organ perfusion, and temporal resolution to fulfill the needs of cardiac CT. Because of the increasing number of CT examinations in all age groups and overall medical-driven radiation exposure, dose reduction remains a hot...
Mon Sep 16, 2019 03:00
Objective The aim of this study was to compare the risk of hypersensitivity reactions to iopromide after intra-arterial (IA) administration and intravenous (IV) administration. Materials and Methods Four observational studies were pooled. Almost half of the study population (48.1%) was from Europe, and one quarter each from China (27.6%) and other Asia countries (24.1%). All patients received iopromide either intra-arterially or intravenously for angiographic procedures (mostly cardio-angiography)...
Mon Sep 16, 2019 03:00
To determine whether blockade of the chemokine receptor CXCR4 might alter the tumor microenvironment and inhibit tumor growth, we tested the efficacy of the CXCR4 antagonist X4-136 as a single agent and in combination with various immune checkpoint inhibitors in the syngeneic murine melanoma model B16-OVA. We also tested its activity alone and in combination with axitinib in the renal cancer model Renca. We found that X4-136 exhibited potent single agent antitumor activity in the B16-OVA model that...
Thu Sep 12, 2019 03:00
A proportion of patients diagnosed with melanoma has a positive family history. Despite increasing knowledge on the genes responsible for familial clustering, the genetic basis in the majority of the families with an inherited predisposition to melanoma remains to be clarified. To identify novel melanoma-susceptibility genes, we applied whole-exome sequencing on DNA from two members of a family with four melanoma cases, not explained by established high penetrance melanoma-susceptibility genes. Whole-exome...
Thu Sep 12, 2019 03:00
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