Related ArticlesMicrofluidic Droplet Digital PCR Is a Powerful Tool for Detection of BRAF and TERT Mutations in Papillary Thyroid Carcinomas. Cancers (Basel). 2019 Dec 02;11(12): Authors: Ylli D, Patel A, Jensen K, Li ZZ, Mendonca-Torres MC, Costello J, Gomes-Lima CJ, Wartofsky L, Burman KD, Vasko VV Abstract We examined the utility of microfluidic digital PCR (dPCR) for detection of BRAF and TERT mutations in thyroid tumors. DNA extracted from 100 thyroid...
Sun Dec 08, 2019 13:03
Related ArticlesEpstein-Barr Virus-Associated Smooth Muscle Tumor of the Spine after Bone Marrow Transplant - a case report and review of literature. World Neurosurg. 2019 Dec 03;: Authors: Calafiore R, Mouchtouris N, Flomenberg N, Harrop JS Abstract BACKGROUND: Epstein-Barr virus associated smooth muscle tumors are rare neoplasms that have been found to develop in immunocompromised patients. Three distinct groups of affected patients have been described;...
Sat Dec 07, 2019 14:26
Related ArticlesSmall-cell variant renal oncocytoma: case report on its clinicopathological and genetic characteristics and literature review. Gene. 2019 Dec 03;:144266 Authors: Li K, Wang C, Xiong X, Ma H, Qi Y, Hu W, Xiao S, Zhou X, Pang L, Zou H Abstract INTRODUCTION: Small-cell variant of RO is a rare subtype of renal tumor that can be easily misdiagnosed. To date, only 20 cases had been reported, with its genetic alterations largely unknown due...
Sat Dec 07, 2019 14:26
Related ArticlesMetastatic non-muscle invasive bladder can-cer with cervical lymph node metastasis. Int Braz J Urol. 2019 Nov-Dec;45(6):1270-1274 Authors: Garrido-Abad P, Martin LG, Zarra KV, Menendez AD, Arjona MF Abstract Bladder cancer is a common cancer that may present as superficial, invasive, or metastatic disease. Non-muscle-invasive bladder cancer (NMIBC) represents the majority of bladder cancer diagnoses, but represents a spectrum of disease...
Sat Dec 07, 2019 14:26
Related ArticlesMalignant leydig cell tumor in a 91-year-old man: Case report. Int Braz J Urol. 2019 Nov-Dec;45(6):1260-1265 Authors: Justo RM, Bernabe E, Ronchini MC, Lucas E, Saber G, da Silva LCZ Abstract Testicle tumors are a rare entity among men population, accounting for only 1-1.5% of all can-cers among men. The stromal tumors of the sexual cord correspond just 4% of all testicular cancers. Only 10% of them are malignant. The major representative...
Sat Dec 07, 2019 14:26
Related ArticlesSubsequent development of histiocytic sarcoma and follicular lymphoma: cytogenetics and next-generation sequencing analyses provide evidence for transdifferentiation of early common lymphoid precursor-a case report and review of literature. Virchows Arch. 2019 Dec 05;: Authors: Péricart S, Waysse C, Siegfried A, Struski S, Delabesse E, Laurent C, Evrard S Abstract Histiocytic sarcoma (HS) is a rare aggressive hematologic neoplasm that...
Sat Dec 07, 2019 13:25
Related ArticlesHead-and-neck paragangliomas: An overview of 54 cases operated at a tertiary care center. South Asian J Cancer. 2019 Oct-Dec;8(4):237-240 Authors: Singh S, Madan R, Singh MK, Thakar A, Sharma SC Abstract Background: Head-and-neck paragangliomas (HNP's) are rare autonomic neoplasms associated with high morbidity and mortality. We aimed to study epidemiology, clinicopathological correlation, and management of HNP to assist clinicians in...
Sat Dec 07, 2019 13:25
Related ArticlesProgressive dyspnea and a right atrial mass in an 80-year-old man. Autops Case Rep. 2019 Oct-Dec;9(4):e2019135 Authors: Aiello VD, Tanigawa RY, Chate RC, de Campos FPF, Mansur AJ Abstract Hepatocellular carcinoma (HCC) is among the five most frequent causes of cancer death worldwide, according to the WHO. The disease is related to alcohol abuse, viral infections, and other causes of cirrhosis, and unfortunately, in some developed countries,...
Sat Dec 07, 2019 13:25
Related ArticlesInfantile synchronous primary bilateral testicular germ cell tumor: a case report and review of the literature. Transl Androl Urol. 2019 Oct;8(5):540-547 Authors: Zhu L, Chen G, Shen Y, Wang X, Gao L, Zhao Y, Ru W, Xu D, Tang D Abstract Testicular tumors are uncommon in adults, accounting for <1% of all cancers, with testicular germ cell tumors (TGCTs) representing the majority (>95%) of reported cases. Adult and prepubertal TGCTs...
Sat Dec 07, 2019 13:25
Related ArticlesPhyllodes tumor with metastases to the skull managed with local excision: A case report. Rare Tumors. 2019;11:2036361319890710 Authors: Patel R, Mehta A, Suri K, Bocian H, Hu J Abstract The behavior of phyllodes tumors is unpredictable and can behave as benign fibroadenomas or malignant neoplasms mimicking the course of aggressive sarcomas, characterized by distant metastases and a high short-term mortality. The malignant forms are treated...
Sat Dec 07, 2019 13:25
Related ArticlesThe Prognostic Significance Of JMJD3 In Primary Sarcomatoid Carcinoma Of The Lung, A Rare Subtype Of Lung Cancer. Onco Targets Ther. 2019;12:9385-9393 Authors: Li S, Jiang L, He Q, Wei W, Wang Y, Zhang X, Liu J, Chen K, Chen J, Xie D Abstract Introduction: Primary sarcomatoid carcinoma of the lung (PSC) is a rare subtype of non-small cell lung cancer, which has a bad prognosis and lacks biomarkers for its diagnosis and prognosis. Recent...
Sat Dec 07, 2019 13:25
Related ArticlesThe Role of PET/CT in the Imaging of Pancreatic Neoplasms. Semin Ultrasound CT MR. 2019 Dec;40(6):500-508 Authors: Duan H, Baratto L, Iagaru A Abstract Pancreas cancer is a complex disease and its prognosis is related to the origin of the tumor cell as well as the stage of disease at the time of diagnosis. Pancreatic adenocarcinomas derive from the exocrine pancreas and are the fourth leading cause of cancer-related deaths in the United...
Sat Dec 07, 2019 13:25
Related ArticlesRare Solid Tumor of the Exocrine Pancreas: A Pictorial Review. Semin Ultrasound CT MR. 2019 Dec;40(6):483-499 Authors: Dioguardi Burgio M, Ronot M, Vilgrain V Abstract Numerous other solid primary neoplasms may arise from the pancreas besides primary ductal adenocarcinomas and neuroendocrine tumors. Although diagnosis can be difficult because of the very low incidence of these tumors, knowledge of several, typical, epidemiologic, biological,...
Sat Dec 07, 2019 13:25
Related ArticlesPrognostic impact of platinum sensitivity in ovarian carcinoma patients with brain metastasis. BMC Cancer. 2019 Dec 05;19(1):1194 Authors: da Costa AABA, Dos Santos ES, Cotrim DP, Pandolfi NC, Cesca MG, Mantoan H, Sanches SM, Ribeiro ARG, de Brot L, Bonvolim G, Sanematsu PI, de Souza RP, Maya JML, de Souza Castro F, da Nogueira Silveira Lima JP, Chen MJ, Guimarães APG, Baiocchi G Abstract BACKGROUND: Brain metastasis (BM) is a rare event...
Sat Dec 07, 2019 13:25
Related ArticlesCan postfertile life stages evolve as an anticancer mechanism? PLoS Biol. 2019 Dec 05;17(12):e3000565 Authors: Thomas F, Giraudeau M, Renaud F, Ujvari B, Roche B, Pujol P, Raymond M, Lemaitre JF, Alvergne A Abstract Why a postfertile stage has evolved in females of some species has puzzled evolutionary biologists for over 50 years. We propose that existing adaptive explanations have underestimated in their formulation an important parameter...
Fri Dec 06, 2019 14:20
Related ArticlesDGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis. J Clin Invest. 2019 Dec 05;: Authors: Rivera B, Nadaf J, Fahiminiya S, Apellaniz-Ruiz M, Saskin A, Chong AS, Sharma S, Wagener R, Revil T, Condello V, Harra Z, Hamel N, Sabbaghian N, Muchantef K, Thomas C, de Kock L, Hébert-Blouin MN, Bassenden AV, Rabenstein H, Mete O, Paschke R, Pusztaszeri MP, Paulus W, Berghuis A, Ragoussis J, Nikiforov YE, Siebert R, Albrecht...
Fri Dec 06, 2019 14:20
Related ArticlesMelanotic neuroectodermal tumor of infancy in ovary: A rare case report. Medicine (Baltimore). 2019 Dec;98(49):e18181 Authors: Liu Z, Li M, Tang X, Xiao Y, Xiao Z, Li Y Abstract RATIONALE: Melanotic neuroectodermal tumor of infancy (MNTI) is an extremely rare benign pigmented neoplasm of neural crest origin with rapid expansile growth and a high recurrence rate. It is predominantly found in infants of <1 year of age, involvement of...
Fri Dec 06, 2019 14:20
Related ArticlesMultiple sites of soft-tissue metastases secondary to lung cancer: A case report. Medicine (Baltimore). 2019 Dec;98(49):e18162 Authors: Zhu X, Chen J, Yang F, Tang C Abstract RATIONALE: The prognosis of lung cancer is dismal, which has resulted in lung carcinoma being one of the leading causes of cancer-related deaths worldwide. Non-small cell lung cancer accounts for approximately 80% of all types of lung carcinoma. The skeletal system...
Fri Dec 06, 2019 14:20
Related ArticlesInsulin Autoantibody Syndrome: Varying Clinical Presentations and Response Patterns of an Underrecognized Entity. Indian J Endocrinol Metab. 2019 Sep-Oct;23(5):540-544 Authors: Manjunath PR, Pavithran PV, Bhavani N, Kumar H, Nair V, Menon AS, Menon UV, Abraham N, Narayanan P, Ruben R Abstract Context: Insulin autoantibody syndrome (IAAS) is considered to be a rare cause of hyperinsulinaemic hypoglycaemia. Lack of familiarity with the...
Fri Dec 06, 2019 14:20
Related ArticlesHow I treat NTRK gene fusion-positive cancers. ESMO Open. 2019;4(Suppl 2):e000612 Authors: Lassen U Abstract NTRK fusions are found at low frequencies (commonly <1%) in a range of common tumour types and at high frequencies (up to or greater than 90%) in rare cancer types (secretory breast carcinoma, mammary analogue secretory carcinoma and infantile fibrosarcoma). The fusions typically occur in a mutually exclusive fashion with other...
Fri Dec 06, 2019 14:20
Related ArticlesEwing sarcoma and Ewing-like tumors. Virchows Arch. 2019 Dec 04;: Authors: Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP Abstract Ewing sarcoma (ES) and Ewing-like sarcomas are highly aggressive round cell mesenchymal neoplasms, most often occurring in children and young adults. The identification of novel molecular alterations has greatly contributed to a profound reappraisal of classification, to the extent that the category of undifferentiated...
Fri Dec 06, 2019 13:21
Related ArticlesThe Ubiquitin specific Protease Usp7, a novel Merkel cell polyomavirus Large T-Antigen interaction partner, modulates viral DNA replication. J Virol. 2019 Dec 04;: Authors: Czech-Sioli M, Siebels S, Radau S, Zahedi RP, Schmidt C, Dobner T, Grundhoff A, Fischer N Abstract Merkel Cell Polyomavirus (MCPyV) is the major cause for Merkel Cell Carcinoma (MCC), a rare but highly aggressive skin cancer predominantly found in elderly and immunosuppressed...
Fri Dec 06, 2019 13:21
Related ArticlesInteractions of pharmaceutical companies with world countries, cancers and rare diseases from Wikipedia network analysis. PLoS One. 2019;14(12):e0225500 Authors: Rollin G, Lages J, Serebriyskaya TS, Shepelyansky DL Abstract Using the English Wikipedia network of more than 5 million articles we analyze interactions and interlinks between the 34 largest pharmaceutical companies, 195 world countries, 47 rare renal diseases and 37 types of...
Fri Dec 06, 2019 02:17
Related ArticlesUp-regulated microRNA-33b inhibits epithelial-mesenchymal transition in gallbladder cancer through downregulating CROCC. Biosci Rep. 2019 Dec 04;: Authors: Xu G, Wei X, Tu Q, Zhou C Abstract Gallbladder cancer (GBC) is a relatively rare but fatal gastrointestinal tumor. The microRNA-33b (miR-33b), a member of miR-33 family, is reported to function as a tumor suppressor in various cancers. Notably, miR-33 was predicted to target CROCC...
Fri Dec 06, 2019 02:17
Related ArticlesArtificial intelligence for precision medicine in neurodevelopmental disorders. NPJ Digit Med. 2019;2:112 Authors: Uddin M, Wang Y, Woodbury-Smith M Abstract The ambition of precision medicine is to design and optimize the pathway for diagnosis, therapeutic intervention, and prognosis by using large multidimensional biological datasets that capture individual variability in genes, function and environment. This offers clinicians the opportunity...
Fri Dec 06, 2019 02:17
Related Articles[Magnetic resonance imaging characteristics and differential diagnosis of common sellar cystic lesions]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Nov 07;54(11):819-825 Authors: Liu H, Lu X, Hang W, Liu G Abstract Objective: To investigate magnetic resonance imaging (MRI) characteristic and differential diagnostic keypoints of common sellar regional cystic lesions with the purpose of improving differential diagnostic accuracy....
Fri Dec 06, 2019 02:17
Related ArticlesClinicopathologic Features of Diencephalic Neuronal and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 03;: Authors: Ho CY, Bornhorst M, Almira-Suarez MI, Donev K, Grafe M, Gordish-Dressman H, Rodriguez FJ Abstract Neuronal/mixed glioneuronal tumors are central nervous system neoplasms composed of neoplastic neuronal cell components or a mixture of glial and neuronal elements. They occur in cerebral hemispheres, posterior fossa,...
Wed Dec 04, 2019 14:18
Related ArticlesDefining the Supportive Care Needs and Psychological Morbidity of Patients With Functioning Versus Nonfunctioning Neuroendocrine Tumors: Protocol for a Phase 1 Trial of a Nurse-Led Online and Phone-Based Intervention. JMIR Res Protoc. 2019 Dec 03;8(12):e14361 Authors: Guccione L, Gough K, Drosdowsky A, Fisher K, Price T, Pavlakis N, Khasraw M, Wyld D, Ransom D, Kong G, Rogers M, Leyden S, Leyden J, Michael M, Schofield P Abstract BACKGROUND:...
Wed Dec 04, 2019 14:18
Related ArticlesClinicopathological features of malignant urachal tumor: A hospital-based cancer registry data in Japan. Int J Urol. 2019 Dec 02;: Authors: Nagumo Y, Kojima T, Shiga M, Kojo K, Tanaka K, Kandori S, Kimura T, Kawahara T, Kawai K, Okuyama A, Higashi T, Nishiyama H Abstract OBJECTIVES: To identify the clinicopathological features of malignant urachal tumor in Japan, and analyze the 5-year overall survival of malignant urachal tumor patients....
Wed Dec 04, 2019 14:18
Related ArticlesA large family with CYLD cutaneous syndrome: medical genetics at the community level. J Community Genet. 2019 Dec 03;: Authors: Arruda AP, Cardoso-Dos-Santos AC, Mariath LM, Feira MF, Kowalski TW, Bezerra KRF, da Silva LACT, Ribeiro EM, Schuler-Faccini L Abstract Germline mutations in the cylindromatosis gene (CYLD) are associated with a rare autosomal dominant disease known as CYLD cutaneous syndrome (CCS). Patients present multiple...
Wed Dec 04, 2019 14:18
Related ArticlesCD138-negative plasma cell myeloma: a diagnostic challenge and a unique entity. BMJ Case Rep. 2019 Dec 01;12(11): Authors: Setiadi AF, Sheikine Y Abstract Plasma cell neoplasms may exhibit variations in morphology and immunophenotype, which can mimic mature B-cell lymphoproliferative disorders and pose diagnostic challenges. This case illustrates a rare entity of plasma cell myeloma, where the entire plasma cell population exhibited lymphoid...
Wed Dec 04, 2019 14:18
Related ArticlesChallenges and solutions to the study of rare childhood tumors. Curr Opin Pediatr. 2019 Nov 27;: Authors: Fair D, Potter SL, Venkatramani R Abstract PURPOSE OF REVIEW: The majority of progress made in pediatric oncology over the past 50 years has been achieved in the most common cancers. Rare pediatric cancers, which collectively comprise more than 10% of all pediatric cancers, pose multiple challenges to researchers and clinicians, all...
Wed Dec 04, 2019 13:15
Related ArticlesRare Case of Lipomatous Mixed Tumor With Follicular Differentiation. Am J Dermatopathol. 2019 Nov 26;: Authors: Doan L, Pham C, Elsensohn A, Kraus C, Binder S Abstract Cutaneous mixed tumors are adnexal neoplasms characterized by a mixture of epithelial, myoepithelial, and stromal components of varying proportions. The diagnosis may be of little challenge when chondroid or myxoid components are dominant. However, there are variants of...
Wed Dec 04, 2019 13:15
Related ArticlesPrimary scrotal melanoma: it is time to destigmatize genital lesions. An Bras Dermatol. 2019 Nov 02;: Authors: Ãzkur E, Altunay Ä°K Abstract Primary male genital melanomas are very rare; they are associated with high mortality and late detection. Scrotal melanoma is the least common presentation and only 23 cases have been reported. Herein, the authors present a 30-year-old patient with stage IIIC (T4b, N2a, M0) scrotal melanoma in order...
Wed Dec 04, 2019 13:15
Related ArticlesTumor lysis syndrome in gynecologic cancers: An uncommon but important diagnosis to recognize. Gynecol Oncol Rep. 2019 Nov;30:100514 Authors: Castellano T, Bulard BA, Staley A, Moore KN Abstract Objectives: To describe the incidence, treatment and outcomes associated with tumor lysis syndrome (TLS) in women with gynecologic cancer (GOC). Methods: A retrospective multi-institutional review of TLS associated with GOC. Women presenting...
Wed Dec 04, 2019 13:15
Related ArticlesChallenges associated with limited-resources cancer care facility: Bilateral breast myeloid sarcoma as an example. Clin Case Rep. 2019 Nov;7(11):2022-2026 Authors: Khoshnaw N, Yassin AK, Alwan AF, Hassan HA, Mula-Hussain L Abstract Myeloid sarcoma (MS) is a rare myeloid malignancy. It can arise before, concurrent with, or following different malignant hematological diseases, most commonly acute myeloid leukemia (AML), myelodysplastic...
Wed Dec 04, 2019 13:15
Related ArticlesSuccessful Re-administration of Osimertinib in Osimertinib-induced Interstitial Lung Disease with an Organizing Pneumonia Pattern: A Case Report and Literature Review. Intern Med. 2019 Nov 29;: Authors: Itano J, Higo H, Ohashi K, Makimoto G, Nishii K, Hotta K, Miyahara N, Maeda Y, Kiura K Abstract Osimertinib is the standard therapy for epidermal-growth-factor-receptor (EGFR)-mutant lung cancers. We herein report a case of osimertinib-induced...
Wed Dec 04, 2019 13:15
Related ArticlesHeterogeneity of clinical management of low-grade gastric lymphoma of mucosa-associated lymphoid tissue. An audit of 198 patients in Spain. Gastroenterol Hepatol. 2019 Nov 28;: Authors: Puig I, Sanabria E, Feu F, Couto I, Blanco M, Alonso P, Gisbert JP, McNicholl AG, Seoane A, Bory F, Polo F, Orivé V, Ponce J, Borda F, Hervás A, Pérez-Aisa Ã, Rivera R, Quintero E, Nicolás-Pérez D, Bujanda L, Rodrigo L, Calvet X, Spanish Gastroenterological Association...
Wed Dec 04, 2019 13:15
Related ArticlesThyroid metastasis from chondrosarcoma. Medicine (Baltimore). 2019 Nov;98(47):e18043 Authors: Wu ZH, Dai JY, Shi JN, Fang MY, Cao J Abstract For chondrosarcoma, metastasis to the thyroid gland is extremely rare. The diagnosis and treatment of thyroid metastasis from chondrosarcoma are discussed here.We found a case of thyroid malignancy occurring after treatment of chondrosarcoma. We reviewed patient characteristics, histological presentations...
Wed Dec 04, 2019 13:15
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