The emergence of drug resistance limits the efficacy of targeted therapies in human tumors. The prevalent view is that resistance is a fait accompli: when treatment is initiated, cancers already contain drug-resistant mutant cells. Bacteria exposed to antibiotics transiently increase their mutation rates (adaptive mutability), thus improving the likelihood of survival. We investigated whether human colorectal cancer (CRC) cells likewise exploit adaptive mutability to evade therapeutic pressure. We...
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Risk of heart disease and stroke reduced even in people with genetic susceptibility to the conditions Related items fromOnMedica Physical activity might offset harms of time spent sitting Heart disease and stroke deaths plummet in Scotland One in two women and one in three men will develop neurological disease Coronary heart disease remains UK ’s biggest killer Most supplements offer no real benefit, some might increase risks (Source: OnMedica Latest News)MedWorm Message: If you are looking to buy...
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The PACE ‘Steps to Success’ programme is a complex educational and development intervention for staff to improve palliative care in long-term care facilities (LTCFs). In a cluster randomized controlled trial, ... (Source: Implementation Science)
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(Mary Ann Liebert, Inc./Genetic Engineering News) The American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS) is pleased to announce that it has acquired JAMA Facial Plastic Surgery and has selected Mary Ann Liebert, Inc. as the new publisher of the Journal, which will be published under the new title of Facial Plastic Surgery& Aesthetic Medicine starting in January 2020. (Source: EurekAlert! - Medicine and Health)MedWorm Message: Have you tried our new medical search engine? More...
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(Bigelow Laboratory for Ocean Sciences) The same technology that powers facial recognition and self-driving cars may soon help Maine's shellfish industry protect people from the dangerous effects of harmful algal blooms. A recent paper reports how researchers can use these deep learning algorithms to forecast shellfish toxicity, just like meteorologists forecast the weather. (Source: EurekAlert! - Medicine and Health)MedWorm Message: If you are looking to buy something in the January Sales please...
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(University of Texas at Austin) Lowering exposure to allergens from mice may lead to improved lung growth for children with asthma living in low-income neighborhoods, helping them avoid lung ailments and possibly live longer, according to newly published research in The Journal of Allergy and Clinical Immunology. (Source: EurekAlert! - Social and Behavioral Science)
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(PLOS) Human toxocariasis -- a neglected tropical disease found worldwide, can cause a range of allergic, neurological, cardiac, and other symptoms. However, it also goes unnoticed in many people who contract the infection. Now, researchers report in PLOS Neglected Tropical Diseases that about 19% of the world's human population carries antibodies against Toxocara. (Source: EurekAlert! - Infectious and Emerging Diseases)MedWorm Message: If you are looking to buy something in the January Sales please...
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(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health, today announced the establishment of the Infectious Diseases Clinical Research Consortium, a clinical trials network that will encompass the Institute's long-standing Vaccine and Treatment Evaluation Units (VTEUs) and create a new consortium leadership group. NIAID intends to provide approximately $29 million per year for seven years...
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(NIH/National Institute of Allergy and Infectious Diseases) An experimental Zika vaccine lowered levels of virus in pregnant monkeys and improved fetal outcomes in a rhesus macaque model of congenital Zika virus infection, according to a new study in Science Translational Medicine. Scientists developed the experimental vaccine and currently are evaluating it in a Phase 2 human clinical trial. The vaccine uses a small circular piece of DNA, or plasmid, containing genes that encode Zika virus surface...
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(Aarhus University) Researchers at the Department of Engineering, Aarhus University, are world leaders in unique brain measurement via a special device fitted in the ear like a hearing aid. The technology is called ear-EEG, and it measures extremely small voltage changes on the surface of the skin inside the ear caused by electrical activity in the brain's neurons. Now, the university has received a EUR 2.7 million grant to ensure further development of this Danish-designed method. (Source: EurekAlert!...
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-- Treating hearing loss early can ward off problems with a child's speech and language development, says the University of Rochester Medical Center. A health care team, including an audiologist, otolaryngologist and speech pathologist, can help... (Source: Drugs.com - Daily MedNews)
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The paediatric intensive care audit network (PICANet) has published its sixteenth clinical audit report summarising paediatric critical care in the UK and Republic of Ireland between 2016 and 2018. (Source: NHS Networks)
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A new study helps to explain the mechanism by which pancreatic cells secrete high levels of insulin during the early stages of diabetes.A central question in diabetes research is why cells of the pancreas, known as beta cells, initially over-secrete insulin. The prevailing theory was that the body may be in the process of becoming “deaf” to insulin, so beta cells secrete more to compensate. But isolated beta cells still over-secrete insulin, which exposes a gap in that theory.In the new study, researchers...
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(Oregon State University) Eating watermelon in the form of powdered supplements helped adult obese mice avoid some detrimental health effects of an unhealthy diet, according to a new Oregon State University study. (Source: EurekAlert! - Medicine and Health)
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Artificial intelligence (AI) software developer Zebra Medical Vision has signed...Read more on AuntMinnie.comRelated Reading: Zebra gets FDA OK for pleural effusion AI software Zebra adds AI1 software to Nuance AI marketplace Zebra teams with Emergent Connect Intelerad partners with Zebra Zebra partners with Medsynaptic for AI in India (Source: AuntMinnie.com Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
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Contrast developer Bayer has received 510(k) clearance from the U.S. Food and...Read more on AuntMinnie.comRelated Reading: Bayer releases new CT injection system Bayer wins FDA nod for use of Gadavist in cardiac MRI Bayer debuts new CT contrast injector at ECR 2019 Bayer announces layoffs in Pa. office Bayer gets breakthrough nod for AI algorithm (Source: AuntMinnie.com Headlines)
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How-to guidance for using abbreviated MRI as a screening tool. (Source: Diagnostic Imaging)
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Hitachi Board of Directors votes to sell company's medical division to Fujifilm is approximately $1.6-billion deal. (Source: Diagnostic Imaging)
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Interview with Mohamad Bassam Sonbol, M.D., author of The Role of Maintenance Strategies in Metastatic Colorectal Cancer: A Systematic Review and Network Meta-analysis of Randomized Clinical Trials (Source: JAMA Specialty Journals Author Interviews)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Conclusions: Engagement is a central process within a complex system of psychosocial constructs operating in therapy. Engagement is emergent, synergistic, and change-inducing - it emanates from, involves, and influences multiple aspects of therapy. Notably, engagement ties two pivotal elements - positive expectations and positive affect - to positive relationships, collaboration, and therapy progress. Implications for practice include an understanding of how providers manage the therapeutic context...
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(University of Pennsylvania School of Medicine) According to a new study from researchers at Penn Medicine, Magnetic Resonance Imaging (MRI) and radiomics could help to characterize the heterogeneity of cancer cells within a tumor and allow for a better understanding of the causes and progression of a person's individual disease. (Source: EurekAlert! - Medicine and Health)
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(University of Pennsylvania) A team led by Rumela Chakrabarti of the University of Pennsylvania has made new discoveries into how a key protein involved in triple-negative breast cancer functions in puberty. (Source: EurekAlert! - Medicine and Health)
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(ECOG-ACRIN Cancer Research Group) The Journal of Clinical Oncology reports results for Arm Z1D of NCI-MATCH, investigating the activity of nivolumab in tumors with DNA mismatch repair deficiencies. Eighteen different cancer types were studied, mostly rare and none colorectal, with DNA repair defects. The results showed a promising signal for nivolumab beyond colorectal cancer. The 36% response rate across a range of cancers compares well with a previous 31% response in colon cancer. (Source: EurekAlert!...
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(American Friends of Tel Aviv University) The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. A new Tel Aviv University study finds that fibroblasts also play a devastating role in the development of breast cancer. (Source: EurekAlert! - Medicine and Health)
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(Fred Hutchinson Cancer Research Center) For many lung cancer patients, the best treatment options involve checkpoint inhibitors, but the drugs only help a small subset of patients. A new study links the most abundant white blood cell to failure of checkpoint inhibitors. (Source: EurekAlert! - Medicine and Health)
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(University of Kentucky) According to a University of Kentucky study, worksite intervention may be key to connecting men in rural Kentucky with critical lung cancer prevention and control resources and services. (Source: EurekAlert! - Medicine and Health)
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. (Source: Epigenetics)
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Publication date: Available online 19 December 2019Source: European UrologyAuthor(s): Susan F. Slovin (Source: European Urology)
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CONCLUSIONS: There is a significant difference between the extracellular matrix in prostate cancer compared to the non-tumor area (control) especially in Gleason 7. Important modifications of the prostatic stromal elements strongly correlate with different Gleason scores and can contribute to predict the pathological staging of prostate cancer. PMID: 31851213 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
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ConclusionComplete surgical resection of the tumor is usually sufficient, but there are reported cases with recurrence. Wedge resection for complete excision can be carried out for tumors arising from visceral pleura. Extra pleural excision can be done without chest wall resection in tumors arising from the parietal pleura. (Source: International Journal of Surgery Case Reports)
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