IJMS, Vol. 21, Pages 59: Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21010059 Authors: Elena Y. Komarova Larisa V. Marchenko Alexander V. Zhakhov Alina D. Nikotina Nikolay D. Aksenov Roman V. Suezov Alexander M. Ischenko Boris A. Margulis Irina V. Guzhova Cancer cells are known to contain high levels of the heat shock protein 70 kDa (Hsp70),...
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IJMS, Vol. 21, Pages 57: Glucocorticoids Equally Stimulate Epithelial Na+ Transport in Male and Female Fetal Alveolar Cells International Journal of Molecular Sciences doi: 10.3390/ijms21010057 Authors: Mandy Laube Diana Riedel Benjamin Ackermann Melanie Haase Ulrich H. Thome Preterm infants frequently suffer from respiratory distress syndrome (RDS), possibly due to lower expression of epithelial Na+ channels (ENaC). RDS incidence is sex-specific, affecting males almost twice...
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IJMS, Vol. 21, Pages 58: Hedgehog Signaling for Urogenital Organogenesis and Prostate Cancer: An Implication for the Epithelial–Mesenchyme Interaction (EMI) International Journal of Molecular Sciences doi: 10.3390/ijms21010058 Authors: Taiju Hyuga Mellissa Alcantara Daiki Kajioka Ryuma Haraguchi Kentaro Suzuki Shinichi Miyagawa Yoshiyuki Kojima Yutaro Hayashi Gen Yamada Hedgehog (Hh) signaling is an essential growth factor signaling pathway especially in the regulation...
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IJMS, Vol. 21, Pages 54: Comparative Analysis and Expression Patterns of the PLP_deC Genes in Dendrobium officinale International Journal of Molecular Sciences doi: 10.3390/ijms21010054 Authors: Lei Zhang Chunyan Jiao Yunpeng Cao Xi Cheng Jian Wang Qing Jin Yongping Cai Studies have shown that the type II pyridoxal phosphate-dependent decarboxylase (PLP_deC) genes produce secondary metabolites and flavor volatiles in plants, and TDC (tryptophan decarboxylase), a member...
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IJMS, Vol. 21, Pages 55: DNA Damage Response and Oxidative Stress in Systemic Autoimmunity International Journal of Molecular Sciences doi: 10.3390/ijms21010055 Authors: Vassilis L. Souliotis Nikolaos I. Vlachogiannis Maria Pappa Alexandra Argyriou Panagiotis A. Ntouros Petros P. Sfikakis The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured signaling pathways that recognize and repair DNA damage, and the immune response to endogenous and/or...
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IJMS, Vol. 21, Pages 52: Extracellular Vesicles and Epigenetic Modifications Are Hallmarks of Melanoma Progression International Journal of Molecular Sciences doi: 10.3390/ijms21010052 Authors: Francesco Mannavola Stella D’Oronzo Mauro Cives Luigia Stefania Stucci Girolamo Ranieri Franco Silvestris Marco Tucci Cutaneous melanoma shows a high metastatic potential based on its ability to overcome the immune system’s control. The mechanisms activated for these...
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IJMS, Vol. 21, Pages 53: Role of Claudin Proteins in Regulating Cancer Stem Cells and Chemoresistance-Potential Implication in Disease Prognosis and Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21010053 Authors: Saiprasad Gowrikumar Amar B. Singh Punita Dhawan Claudins are cell–cell adhesion proteins, which are expressed in tight junctions (TJs), the most common apical cell-cell adhesion. Claudin proteins help to regulate defense and barrier functions,...
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IJMS, Vol. 21, Pages 50: Improving Phenolic Total Content and Monoterpene in Mentha x piperita by Using Salicylic Acid or Methyl Jasmonate Combined with Rhizobacteria Inoculation International Journal of Molecular Sciences doi: 10.3390/ijms21010050 Authors: Cappellari Santoro Schmidt Gershenzon Banchio The effects of plant inoculation with plant growth-promoting rhizobacteria (PGPR) and those resulting from the exogenous application of salicylic acid (SA) or methyl jasmonte...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 51: Biocatalytic Amplification of UV Signal in Capillary Electrophoresis of MicroRNA International Journal of Molecular Sciences doi: 10.3390/ijms21010051 Authors: Ruibin Hu Yi Chen MicroRNAs (miRNAs) are new potential biomarkers for early diagnosis and classification of cancer. This study is the first attempt to use biocatalytic amplification reactions combined with capillary electrophoresis to detect multiple miRNAs simultaneously. In this way, miRNAs, as catalysts,...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 49: Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cell Culture Prevents UVB-Induced Skin Aging in Human Keratinocytes and Dermal Fibroblasts International Journal of Molecular Sciences doi: 10.3390/ijms21010049 Authors: Li Ngo Hwang Wei Liu Liu Yi Human adipose-derived mesenchymal stem cells-conditioned medium (ADSC-CM) contains cytokines and growth factors that can facilitate the regeneration and repair of various tissues...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 48: Missing Link between Molecular Aspects of Ventricular Arrhythmias and QRS Complex Morphology in Left Ventricular Hypertrophy International Journal of Molecular Sciences doi: 10.3390/ijms21010048 Authors: Bacharova The aim of this opinion paper is to point out the knowledge gap between evidence on the molecular level and clinical diagnostic possibilities in left ventricular hypertrophy (LVH) regarding the prediction of ventricular arrhythmias and monitoring the...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 47: Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of α-Synuclein International Journal of Molecular Sciences doi: 10.3390/ijms21010047 Authors: Yamamoto Fukui Adachi Saiki Yamasaki Matsumura Kuroyanagi Hongo Mizobata Kawata Heat shock proteins play roles in assisting other proteins to fold correctly and in preventing the aggregation and accumulation of proteins in misfolded conformations....
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 45: Are Leukaemic Stem Cells Restricted to a Single Cell Lineage? International Journal of Molecular Sciences doi: 10.3390/ijms21010045 Authors: Brown Sánchez Sánchez-García Cancer-stem-cell theory states that most, if not all, cancers arise from a stem/uncommitted cell. This theory revolutionised our view to reflect that cancer consists of a hierarchy of cells that mimic normal cell development. Elegant studies of twins who both developed acute lymphoblastic...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 44: Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair International Journal of Molecular Sciences doi: 10.3390/ijms21010044 Authors: Lyons Hidalgo Perea Weinberg Wittstein McNulty Meniscal injuries, particularly in the avascular zone, have a low propensity for healing and are associated with the development of osteoarthritis. Current meniscal repair techniques are limited...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 46: International Journal of Molecular Science 2019 Best Paper Award International Journal of Molecular Sciences doi: 10.3390/ijms21010046 Authors: International Journal of Molecular Science Editorial Office The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics, and chemistry that have been published in the International...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 42: Combined Linkage Mapping and BSA to Identify QTL and Candidate Genes for Plant Height and the Number of Nodes on the Main Stem in Soybean International Journal of Molecular Sciences doi: 10.3390/ijms21010042 Authors: Ruichao Li Hongwei Jiang Zhanguo Zhang Yuanyuan Zhao Jianguo Xie Qiao Wang Haiyang Zheng Lilong Hou Xin Xiong Dawei Xin Zhenbang Hu Chunyan Liu Xiaoxia Wu Qingshan Chen Soybean is one of the most important food...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 37: Defects in G-Actin Incorporation into Filaments in Myoblasts Derived from Dysferlinopathy Patients Are Restored by Dysferlin C2 Domains International Journal of Molecular Sciences doi: 10.3390/ijms21010037 Authors: Ximena Báez-Matus Cindel Figueroa-Cares Arlek M. Gónzalez-Jamett Hugo Almarza-Salazar Christian Arriagada María Constanza Maldifassi María José Guerra Vincent Mouly Anne Bigot Pablo Caviedes Ana M. Cárdenas Dysferlin is...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 43: The Molecular Mechanisms Underlying Iron Deficiency Responses in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21010043 Authors: Li Chen Yang Iron (Fe) is an essential element required for plant growth and development. Under Fe-deficientconditions, plants have developed two distinct strategies (designated as strategy I and II) to acquire Fe from soil. As a graminaceous species, rice is not a typical strategy II plant, as it not only...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 38: Possible Contribution of Inflammation-Associated Hypoxia to Increased K2P5.1 K+ Channel Expression in CD4+ T cells of the Mouse Model for Inflammatory Bowel Disease International Journal of Molecular Sciences doi: 10.3390/ijms21010038 Authors: Endo Kito Tanaka Kajikuri Tanaka Elboray Suzuki Ohya Previous studies have reported the up-regulation of the two-pore domain K+ channel K2P5.1 in the CD4+ T cells of patients with multiple sclerosis...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 40: Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover International Journal of Molecular Sciences doi: 10.3390/ijms21010040 Authors: Simon Ouro Ala-Ibanibo Presa Delgado Martínez-Chantar Non-alcoholic fatty liver disease (NAFLD) has emerged as one of the main causes of chronic liver disease worldwide. NAFLD comprises a group of conditions characterized by the accumulation of hepatic lipids that...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 41: Anti-Obesity Effects of Microalgae International Journal of Molecular Sciences doi: 10.3390/ijms21010041 Authors: Gómez-Zorita Trepiana González-Arceo Aguirre Milton-Laskibar González Eseberri Fernández-Quintela Portillo In recent years, microalgae have attracted great interest for their potential applications in nutraceutical and pharmaceutical industry as an interesting source of bioactive medicinal products and food ingredients...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 39: Hypoxia in the Initiation and Progression of Neuroblastoma Tumours International Journal of Molecular Sciences doi: 10.3390/ijms21010039 Authors: Carlos Huertas-Castaño María A. Gómez-Muñoz Ricardo Pardal Francisco M. Vega Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors,...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 33: Oral Administration of Lactobacillus Casei Expressing Flagellin A Protein Confers Effective Protection against Aeromonas Veronii in Common Carp, Cyprinus Carpio International Journal of Molecular Sciences doi: 10.3390/ijms21010033 Authors: Jia-Xin Tian Yuan-Huan Kang Guo-Sheng Chu Hong-Jian Liu Yi-Di Kong Lin-Hui Zhao Yu-Xin Kong Xiao-Feng Shan Gui-Qin Wang Aeromonas veronii is a pathogen capable of infecting humans, livestock and aquatic...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 36: Epigenetic Regulation in Etiology of Type 1 Diabetes Mellitus International Journal of Molecular Sciences doi: 10.3390/ijms21010036 Authors: Marie CERNA Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of the pancreatic β-cells, a process in which autoreactive T cells play a pivotal role, and it is characterized by islet autoantibodies. Consequent hyperglycemia is requiring lifelong insulin replacement therapy. T1DM is caused by...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 34: Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression International Journal of Molecular Sciences doi: 10.3390/ijms21010034 Authors: Toshifumi Kishimoto Yuko Yoshikawa Kenichi Yoshikawa Seiji Komeda Despite the effectiveness of cisplatin as an anticancer agent, its trans-isomer, transplatin, is clinically ineffective. Although both isomers target nuclear DNA, there is a large difference in the magnitude...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 35: Proteomic Changes during MCMV Infection Revealed by iTRAQ Quantitative Proteomic Analysis in Maize International Journal of Molecular Sciences doi: 10.3390/ijms21010035 Authors: Mingqing Dang Qi Cheng Ya Hu Jianxiang Wu Xueping Zhou Yajuan Qian Maize chlorotic mottle virus (MCMV) has been occurring frequently worldwide and causes severe yield losses in maize (Zea mays). To better investigate the destructive effects of MCMV infection on maize plants,...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 31: Maternal Dietary Fiber Composition during Gestation Induces Changes in Offspring Antioxidative Capacity, Inflammatory Response, and Gut Microbiota in a Sow Model International Journal of Molecular Sciences doi: 10.3390/ijms21010031 Authors: Yang Li Haoyu Liu Lijia Zhang Yi Yang Yan Lin Yong Zhuo Zhengfeng Fang Lianqiang Che Bin Feng Shengyu Xu Jian Li De Wu To study the effects of maternal dietary fiber composition during gestation...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 26: CaDHN4, a Salt and Cold Stress-Responsive Dehydrin Gene from Pepper Decreases Abscisic Acid Sensitivity in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21010026 Authors: Zhang Liu Ma Wang Haq Meng Zhang Chen Dehydrins play an important role in improving plant resistance to abiotic stresses. In this study, we isolated a dehydrin gene from pepper (Capsicum annuum L.) leaves, designated as CaDHN4. Sub-cellular...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 32: Proteomic Analysis of Quercetin-Treated K562 Cells International Journal of Molecular Sciences doi: 10.3390/ijms21010032 Authors: Brisdelli Di Francesco Giorgi Lizzi Luzi Mignogna Bozzi Schininà Among natural products under investigation for their additive potential in cancer prevention and treatment, the flavonoid quercetin has received attention for its effects on the cell cycle arrest and apoptosis. In the past, we addressed this...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 28: Cell-Based Mechanosensation, Epigenetics, and Non-Coding RNAs in Progression of Cardiac Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21010028 Authors: Ferrari Pesce The heart is par excellence the ‘in-motion’ organ in the human body. Compelling evidence shows that, besides generating forces to ensure continuous blood supply (e.g., myocardial contractility) or withstanding passive forces generated by flow (e.g.,...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 30: Molecular Conformations of Di-, Tri-, and Tetra-α-(2→8)-Linked Sialic Acid from NMR Spectroscopy and MD Simulations International Journal of Molecular Sciences doi: 10.3390/ijms21010030 Authors: Aysegül Turupcu Markus Blaukopf Paul Kosma Chris Oostenbrink By using molecular dynamics simulations with an efficient enhanced sampling technique and in combination with nuclear magnetic resonance (NMR) spectroscopy quantitative structural information on ...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 29: The Maize Class-I SUMO Conjugating Enzyme ZmSCE1d Is Involved in Drought Stress Response International Journal of Molecular Sciences doi: 10.3390/ijms21010029 Authors: Huanyan Wang Meiping Wang Zongliang Xia Post-translational modification of cellular proteins by sumoylation plays a vital role in stress responses of plants. However, the mechanisms underlying the sumoylation’s involvement in stress responses in crop species remain largely unknown....
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 27: Telomerase Does Not Improve DNA Repair in Mitochondria upon Stress but Increases MnSOD Protein under Serum-Free Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21010027 Authors: Alexander Martens Bianca Schmid Olasubomi Akintola Gabriele Saretzki Telomerase is best known for its function in maintaining telomeres but has also multiple additional, non-canonical functions. One of these functions is the decrease of oxidative stress...
Thu Dec 19, 2019 02:00
IJMS, Vol. 21, Pages 25: Cannabinoid Receptors Signaling in the Development, Epigenetics, and Tumours of Male Germ Cells International Journal of Molecular Sciences doi: 10.3390/ijms21010025 Authors: Marco Barchi Elisa Innocenzi Teresa Giannattasio Susanna Dolci Pellegrino Rossi Paola Grimaldi Endocannabinoids are natural lipid molecules whose levels are regulated by specific biosynthetic and degradative enzymes. They bind to and activate two main cannabinoid receptors...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 24: Prediction of Protein–Ligand Interaction Based on the Positional Similarity Scores Derived from Amino Acid Sequences International Journal of Molecular Sciences doi: 10.3390/ijms21010024 Authors: Karasev Sobolev Lagunin Filimonov Poroikov The affinity of different drug-like ligands to multiple protein targets reflects general chemical–biological interactions. Computational methods estimating such interactions analyze the available information...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 23: Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk International Journal of Molecular Sciences doi: 10.3390/ijms21010023 Authors: Micol Massimiani Valentina Lacconi Fabio La Civita Carlo Ticconi Rocco Rago Luisa Campagnolo Implantation of the embryo into the uterine endometrium is one of the most finely-regulated processes that leads to the establishment of a successful pregnancy. A plethora of factors are released in a time-specific...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 20: Correction: Sciacca, F. L., et al. Microduplication of 15q13.3 and Microdeletion of 18q21.32 in a Patient with Moyamoya Syndrome. Int. J. Mol. Sci. 2018, 19, 3675 International Journal of Molecular Sciences doi: 10.3390/ijms21010020 Authors: Sciacca Rizzo Bedini Capone Di Lazzaro Nava Acerbi Rossi Sebastiano Binelli Faragò Gioppo Grisoli Bruzzone Ferroli Pantaleoni Caputi Gomez Parati Bersano...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 21: Discovery of An Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B International Journal of Molecular Sciences doi: 10.3390/ijms21010021 Authors: Xie Wang Su Wang Shen Hemophilia B is a severe blood clotting disorder caused by the deficiency of factor IX (FIX). FIX is not bioavailable when given orally due to poor stability and permeability in the gastrointestinal tract. The feasibility of fusing FIX with transferrin (Tf)...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 22: How to Make Anticancer Drugs Cross the Blood–Brain Barrier to Treat Brain Metastases International Journal of Molecular Sciences doi: 10.3390/ijms21010022 Authors: Angeli Nguyen Janin Bousquet The incidence of brain metastases has increased in the last 10 years. However, the survival of patients with brain metastases remains poor and challenging in daily practice in medical oncology. One of the mechanisms suggested for the persistence of a high incidence...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 18: Knowledge Generation with Rule Induction in Cancer Omics International Journal of Molecular Sciences doi: 10.3390/ijms21010018 Authors: Scala Federico Fortino Greco Majello The explosion of omics data availability in cancer research has boosted the knowledge of the molecular basis of cancer, although the strategies for its definitive resolution are still not well established. The complexity of cancer biology, given by the high heterogeneity of...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 19: Use of QSAR Global Models and Molecular Docking for Developing New Inhibitors of c-src Tyrosine Kinase International Journal of Molecular Sciences doi: 10.3390/ijms21010019 Authors: Ancuceanu Tamba Stoicescu Dinu A prototype of a family of at least nine members, cellular Src tyrosine kinase is a therapeutically interesting target because its inhibition might be of interest not only in a number of malignancies, but also in a diverse array of conditions,...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 17: Association of Complement Factor D and H Polymorphisms with Recurrent Pregnancy Loss International Journal of Molecular Sciences doi: 10.3390/ijms21010017 Authors: Cho Park Ko Ryu Kim Kim Ahn Lee Kim Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses prior to 20 weeks of gestation, and the incidence of RPL is estimated at 1% of all pregnancies. While the etiologies of RPL are diverse, immune...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 15: Influence of Acrylamide Administration on the Neurochemical Characteristics of Enteric Nervous System (ENS) Neurons in the Porcine Duodenum International Journal of Molecular Sciences doi: 10.3390/ijms21010015 Authors: Palus Całka The digestive tract, especially the small intestine, is one of the main routes of acrylamide absorption and is therefore highly exposed to the toxic effect of acrylamide contained in food. The aim of this experiment was to elucidate...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 16: GTP Binding is Necessary for the Activation of a Toxic Mutant Isoform of the Essential GTPase ObgE International Journal of Molecular Sciences doi: 10.3390/ijms21010016 Authors: Dewachter Deckers Martin Herpels Gkekas Versées Verstraeten Fauvart Michiels Even though the Obg protein is essential for bacterial viability, the cellular functions of this universally conserved GTPase remain enigmatic. Moreover, the influence of GTP...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 11: The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis International Journal of Molecular Sciences doi: 10.3390/ijms21010011 Authors: Woo Liu Lin Dorajoo Lee Richards Lee Wongsurawat Nookaew Sorokin Vascular smooth muscle cells (VSMCs) in the arterial wall have diverse functions. In pathological states, the interplay between transcripts...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 13: How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor International Journal of Molecular Sciences doi: 10.3390/ijms21010013 Authors: Ho Tan Lane It has been four decades since the discovery of p53, the designated ‘Guardian of the Genome’. P53 is primarily known as a master transcription factor and critical tumor suppressor, with countless studies detailing the mechanisms by which it regulates a host of...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 12: Distinct Differentiation Characteristics of Endothelium Determine Its Ability to Form Pseudo-Embryos in Tomato Ovules International Journal of Molecular Sciences doi: 10.3390/ijms21010012 Authors: Chaban Baranova Kononenko Khaliluev Smirnova The endothelium is an additional cell layer, differentiating from the inner epidermis of the ovule integument. In tomato (Solanum lycopersicum L.), after fertilization, the endothelium separates from integument...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 14: Genome-Wide Characterization and Gene Expression Analyses of GATA Transcription Factors in Moso Bamboo (Phyllostachys edulis) International Journal of Molecular Sciences doi: 10.3390/ijms21010014 Authors: Wang Yang Lou Wei Zhao Ren Lin Ma Moso bamboo is well-known for its rapid-growth shoots and widespread rhizomes. However, the regulatory genes of these two processes are largely unexplored. GATA transcription factors regulate many...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 9: Ion-Based Cellular Signal Transmission, Principles of Minimum Information Loss, and Evolution by Natural Selection International Journal of Molecular Sciences doi: 10.3390/ijms21010009 Authors: Frieden Gatenby : The Extreme Physical Information EPI principle states that maximum information transmission or, equivalently, a minimum information loss is a fundamental property of nature. Prior work has demonstrated the universal EPI principle allows derivation...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 10: Multikinase Inhibitor Treatment in Thyroid Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21010010 Authors: Ancker Krüger Wehland Infanger Grimm Thyroid cancer is the most common endocrine malignancy. Most thyroid cancer types respond well to conventional treatment consisting of surgery and radioactive iodine (RAI) therapy. Unfortunately, some thyroid cancer types are resistant to surgical and RAI therapy. Multikinase inhibitors...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 7: Cadmium Pathways in Snails Follow a Complementary Strategy between Metallothionein Detoxification and Auxiliary Inactivation by Phytochelatins International Journal of Molecular Sciences doi: 10.3390/ijms21010007 Authors: Martin Dvorak Raimund Schnegg Michael Niederwanger Veronika Pedrini-Martha Peter Ladurner Herbert Lindner Leopold Kremser Reinhard Lackner Reinhard Dallinger Metal detoxification is crucial for animals to cope with environmental...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 5: Tetrahydroquinoline-Isoxazole/Isoxazoline Hybrid Compounds as Potential Cholinesterases Inhibitors: Synthesis, Enzyme Inhibition Assays, and Molecular Modeling Studies International Journal of Molecular Sciences doi: 10.3390/ijms21010005 Authors: Yeray A. Rodríguez Núñez Margarita Gutíerrez Jans Alzate-Morales Francisco Adasme-Carreño Fausto M. Güiza Cristian C. Bernal Arnold R. Romero Bohórquez A series of 44 hybrid compounds that included in...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 6: Characterization of p53 Family Homologs in Evolutionary Remote Branches of Holozoa International Journal of Molecular Sciences doi: 10.3390/ijms21010006 Authors: Martin Bartas Václav Brázda Jiří Červeň Petr Pečinka The p53 family of transcription factors plays key roles in development, genome stability, senescence and tumor development, and p53 is the most important tumor suppressor protein in humans. Although intensively investigated for many years,...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 8: Insight into Nephrocan Function in Mouse Endoderm Patterning International Journal of Molecular Sciences doi: 10.3390/ijms21010008 Authors: Martina Addeo Silvia Buonaiuto Ilaria Guerriero Elena Amendola Feliciano Visconte Antonio Marino Maria Teresa De Angelis Filomena Russo Luca Roberto Pina Marotta Nicola Antonino Russo Anna Iervolino Federica Amodio Mario De Felice Valeria Lucci Geppino Falco Endoderm-derived organs...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 4: Pharmacological Stimulation of Nurr1 Promotes Cell Cycle Progression in Adult Hippocampal Neural Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21010004 Authors: Haena Moon Seong Gak Jeon Jin-il Kim Hyeon soo Kim Sangho Lee Dongok Kim Seungjoon Park Minho Moon Hyunju Chung Nuclear receptor related-1 (Nurr1) protein performs a crucial role in hippocampal neural stem cell (hNSC) development as well as cognitive functions....
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 3: The Terrestrial Carnivorous Plant Utricularia reniformis Sheds Light on Environmental and Life-Form Genome Plasticity International Journal of Molecular Sciences doi: 10.3390/ijms21010003 Authors: Saura R. Silva Ana Paula Moraes Helen A. Penha Maria H. M. Julião Douglas S. Domingues Todd P. Michael Vitor F. O. Miranda Alessandro M. Varani Utricularia belongs to Lentibulariaceae, a widespread family of carnivorous plants that possess ultra-small...
Wed Dec 18, 2019 02:00
IJMS, Vol. 21, Pages 2: Inhibition of Protein Prenylation of GTPases Alters Endothelial Barrier Function International Journal of Molecular Sciences doi: 10.3390/ijms21010002 Authors: Muhammad Aslam Christian Troidl Christian Tanislav Susanne Rohrbach Dursun Gündüz Christian W. Hamm The members of Rho family of GTPases, RhoA and Rac1 regulate endothelial cytoskeleton dynamics and hence barrier integrity. The spatial activities of these GTPases are regulated by post-translational...
Wed Dec 18, 2019 02:00
JCDD, Vol. 7, Pages 1: Scar Formation with Decreased Cardiac Function Following Ischemia/Reperfusion Injury in 1 Month Old Swine Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7010001 Authors: Emma J Agnew Nivedhitha Velayutham Gabriela Matos Ortiz Christina M Alfieri Luis Hortells Victoria Moore Kyle W Riggs R. Scott Baker Aaron M Gibson Sithara Raju Ponny Tarek Alsaied Farhan Zafar Katherine E Yutzey Studies in mice show a brief...
Wed Dec 18, 2019 02:00
JCM, Vol. 9, Pages 21: Plagiocephaly after Neonatal Developmental Dysplasia of the Hip at School Age
JCM, Vol. 9, Pages 21: Plagiocephaly after Neonatal Developmental Dysplasia of the Hip at School Age Journal of Clinical Medicine doi: 10.3390/jcm9010021 Authors: Valkama Aarnivala Sato Harila Heikkinen Pirttiniemi Developmental dysplasia of the hip (DDH) may require early abduction treatment with infants sleeping on their back for the first few months of life. As sleeping on back is known to cause deformational plagiocephaly, we assessed school age children treated...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 20: Use of DIAGNOdent and VistaProof in diagnostic of Pre-Cavitated Caries Lesions—A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9010020 Authors: Iranzo-Cortés Montiel-Company Almerich-Torres Bellot-Arcís Almerich-Silla Objective: To analyse the published evidence of the validity of DIAGNDOdent and VistaProof in diagnosing carious depths in pre-cavitated lesions. Material and methods: A systematic review was carried...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 19: Co-Morbidities and Sex Differences in Long-Term Quality-of-Life Outcomes among Patients with and without Diabetes after Total Knee Replacement: Five-Year Data from Registry Study Journal of Clinical Medicine doi: 10.3390/jcm9010019 Authors: Tew Dowsey Choong Choong Clarke Improved understanding of quality-of-life (QoL) outcomes can provide valuable information on intervention effectiveness and guide better patient care. The aim of this study was...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 18: Influence of Alternate Hot and Cold Thermal Stimulation in Cortical Excitability in Healthy Adults: An fMRI Study Journal of Clinical Medicine doi: 10.3390/jcm9010018 Authors: Sharon Chia-Ju Chen Jau-Hong Lin Jui-Sheng Hsu Chiu-Ming Shih Jui-Jen Lai Miao-Ju Hsu Stroke rehabilitation using alternate hot and cold thermal stimulation (altTS) has been reported to improve motor function in hemiplegia; however, the influence of brain excitability induced...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 13: Identification of the Pelvic Organ Prolapse/Incontinence Sexual Questionnaire—IUGA Revised (PISQ-IR) Cutoff Scores for Impaired Sexual Function in Women with Pelvic Floor Disorders Journal of Clinical Medicine doi: 10.3390/jcm9010013 Authors: Magdalena Emilia Grzybowska Konrad Futyma Dariusz Wydra The aim of this cross-sectional study was to determine the cutoff scores for sexual dysfunction in disease-specific Pelvic Organ Prolapse/Incontinence Sexual Questionnaire—IUGA...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 11: Effects of Encircled Abdominal Compression Device in Colonoscopy: A Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9010011 Authors: Nishizawa Suzuki Higuchi Ebinuma Toyoshima : Background and Aim: The efficacy of encircling abdominal compression devices in colonoscopies is inconsistent. We performed a meta-analysis of randomized controlled trials (RCTs) in which encircling abdominal compression devices were compared with control in...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 16: The Relationship between Sleep Bruxism Intensity and Renalase Concentration—An Enzyme Involved in Hypertension Development Journal of Clinical Medicine doi: 10.3390/jcm9010016 Authors: Helena Martynowicz Mieszko Wieckiewicz Rafal Poreba Anna Wojakowska Joanna Smardz Lidia Januszewska Iwona Markiewicz-Gorka Grzegorz Mazur Krystyna Pawlas Pawel Gac Background and objectives: Renalase, a novel amine oxidase, is involved in the development...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 14: Changes in Opioid Prescribing Behaviors among Family Physicians Who Participated in a Weekly Tele-Mentoring Program Journal of Clinical Medicine doi: 10.3390/jcm9010014 Authors: Díaz Zhao Cronin Jaglal Bombardier Furlan A weekly tele-mentoring program was implemented in Ontario to help address the growing opioid crisis through teaching and mentoring family physicians on the management of chronic pain and opioid prescribing. This study assessed...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 15: Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy Journal of Clinical Medicine doi: 10.3390/jcm9010015 Authors: Tarantino Citro Capone Focusing on previously published mechanisms of non-alcoholic fatty liver disease (NAFLD), their uncertainty does not always permit a clear elucidation of the grassroot alterations that are at the basis of the wide-spread illness, and thus curing it is still a challenge. There is somehow exceptional...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 12: NPC1 Deficiency in Mice is Associated with Fetal Growth Restriction, Neonatal Lethality and Abnormal Lung Pathology Journal of Clinical Medicine doi: 10.3390/jcm9010012 Authors: Rodriguez-Gil Watkins-Chow Baxter Yokoyama Zerfas Starost Gahl Malicdan Porter Platt Pavan The rare lysosomal storage disorder Niemann-Pick disease type C1 (NPC1) arises from mutation of NPC1, which encodes a lysosomal transmembrane protein essential...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 17: Histological Scores Validate the Accuracy of Hepatic Iron Load Measured by Signal Intensity Ratio and R2* Relaxometry MRI in Dialysis Patients Journal of Clinical Medicine doi: 10.3390/jcm9010017 Authors: Guy Rostoker Mireille Laroudie Raphaël Blanc Mireille Griuncelli Christelle Loridon Fanny Lepeytre Clémentine Rabaté Yves Cohen Almost all haemodialysis patients are treated with parenteral iron to compensate for blood loss and to allow the...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 8: Lipophilicity of Bacteriochlorin-Based Photosensitizers as a Determinant for PDT Optimization through the Modulation of the Inflammatory Mediators Journal of Clinical Medicine doi: 10.3390/jcm9010008 Authors: Pucelik Arnaut Dąbrowski : Photodynamic therapy (PDT) augments the host antitumor immune response, but the role of the PDT effect on the tumor microenvironment in dependence on the type of photosensitizer and/or therapeutic protocols has not been clearly...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 9: Anti-Inflammatory Action of Heterogeneous Nuclear Ribonucleoprotein A2/B1 in Patients with Autoimmune Endocrine Disorders Journal of Clinical Medicine doi: 10.3390/jcm9010009 Authors: Coppola Cancemi Tomasello Guarnotta Pitrone Failla Cillino Feo Pizzolanti Giordano Our previous studies documented that human fibroblast-limbal stem cells (f-LSCs) possess immunosuppressive capabilities, playing a role in regulating T-cell activity....
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 7: Drain Amylase or Lipase for the Detection of POPF—Adding Evidence to an Ongoing Discussion Journal of Clinical Medicine doi: 10.3390/jcm9010007 Authors: Müssle Oehme Schade Sommer Bogner Hempel Pochhammer Kahlert Distler Weitz Welsch ： Objectives: A postoperative pancreatic fistula (POPF) is defined as a threefold increase in the amylase concentration in abdominal drains on or after the third postoperative day (POD). However,...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 10: HCMV Infection in a Mesenchymal Stem Cell Niche: Differential Impact on the Development of NK Cells Versus ILC3 Journal of Clinical Medicine doi: 10.3390/jcm9010010 Authors: Ising Weinhold Bennstein Zimmermann Degistirici Kögler Meisel Hengel Timm Uhrberg Human cytomegalovirus (HCMV) is highly prevalent in most populations worldwide and has a major influence on shaping the human immune system. Natural killer (NK) cells are important...
Thu Dec 19, 2019 02:00
JCM, Vol. 9, Pages 6: Radioprotective and Antimutagenic Effects of Pycnanthus angolensis Warb Seed Extract against Damage Induced by X Rays Journal of Clinical Medicine doi: 10.3390/jcm9010006 Authors: Achel Alcaraz-Saura Castillo Olivares Alcaraz Although different studies have demonstrated different applications of Pycnanthus angolensis extracts in traditional African and Asian medicine, its possible antimutagenic or genoprotective capacities have never been explored....
Wed Dec 18, 2019 02:00
JCM, Vol. 9, Pages 4: Chronic Kidney Disease Has a Graded Association with Death and Cardiovascular Outcomes in Stable Coronary Artery Disease: An Analysis of 21,911 Patients from the CLARIFY Registry Journal of Clinical Medicine doi: 10.3390/jcm9010004 Authors: Vidal-Petiot Greenlaw Kalra Garcia-Moll Tardif Ford Zamorano Ferrari Tendera Fox Steg on behalf of the CLARIFY investigators : Chronic kidney disease (CKD) is associated with an increased...
Wed Dec 18, 2019 02:00
JCM, Vol. 9, Pages 5: Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9010005 Authors: Ihlen Støen Boswell Regnier Fjørtoft Gaebler-Spira Labori Loennecken Msall Möinichen Peyton Schreiber Silberg Songstad Vågen Øberg Adde Background: Early identification of cerebral palsy (CP) during infancy will provide...
Wed Dec 18, 2019 02:00
JCM, Vol. 9, Pages 3: Relation between Heart Rate Variability and Disease Course in Multiple Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm9010003 Authors: Tatjana Reynders Yori Gidron Jella De Ville Maria Bjerke Ilse Weets Ann Van Remoortel Lindsay Devolder Miguel D’haeseleer Jacques De Keyser Guy Nagels Marie B. D’hooghe Little is known about the interplay between the autonomic nervous system and disease activity in multiple sclerosis (MS). We...
Wed Dec 18, 2019 02:00
JFB, Vol. 11, Pages 1: Physicochemical, Mechanical, and Antimicrobial Properties of Novel Dental Polymers Containing Quaternary Ammonium and Trimethoxysilyl Functionalities Journal of Functional Biomaterials doi: 10.3390/jfb11010001 Authors: Bienek Giuseppetti Frukhtbeyn Hiers Esteban Florez Khajotia Skrtic The aims of this study were to evaluate the physicochemical and mechanical properties, antimicrobial (AM) functionality, and cytotoxic potential of novel...
Wed Dec 18, 2019 02:00
JFMK, Vol. 5, Pages 1: Balance Performance across the Lifespan Assessed by the Leonardo Mechanograph®: A Cross-Sectional Study Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5010001 Authors: Wiegmann Felsenberg Gast Börst Armbrecht Dietzel Reference values of sway parameters have not been published for the Leonardo mechanograph® so far. The aim of this cross-sectional study was to determine normative values on postural control measured...
Thu Dec 19, 2019 02:00
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