Volume 31, Issue 1, December 2020, Page 1-16 . (Source: Food and Agricultural Immunology)
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Volume 31, Issue 1, December 2020, Page 63-74 . (Source: Food and Agricultural Immunology)
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Volume 31, Issue 1, December 2020, Page 17-32 . (Source: Food and Agricultural Immunology)
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Volume 31, Issue 1, December 2020, Page 75-83 . (Source: Food and Agricultural Immunology)
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Volume 31, Issue 1, December 2020, Page 45-62 . (Source: Food and Agricultural Immunology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Volume 31, Issue 1, December 2020, Page 33-44 . (Source: Food and Agricultural Immunology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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AbstractAllergy to house dust mites (HDMs) can cause allergic rhinitis, allergic asthma and allergic skin disorders, which is becoming an enormous worldwide health and economic burden. To explore the relationship between air pollution and HDMs sensitization in children, this study used immunoblotting to determine the concentration of HDM serum-specific IgE (sIgE) in children with allergic diseases in Hangzhou. HDM sIgE was used to reflect the sensitization of children with HDMs. Using the meteorological...
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This study aims to investigate phonological acquisition and development among Putonghua-speaking children with ASD. Data were collected from participants recruited in Shanghai, China. Two experiments were conducted. In experiment I, phonological acquisition was compared between 16 children with ASD aged 3-6 years and 16 age-matched typically developing (TD) children. In experiment II, phonological acquisition was compared between 26 children with ASD over 6 years old and 26 receptive-language-age-matched...
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Conclusions Combined quantitative and qualitative findings suggest that, while unresponsive communication partners may not have robust effects on spoken language, they elicit strong emotional reactions from PWA and affect their communication experience. These findings support the need for communication partner training and suggest that training PWA on emotion regulation or relaxation techniques may help assuage their anxiety during socially challenging everyday communication and increase social participation....
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Authors: Barry WJ PMID: 31851993 [PubMed - as supplied by publisher] (Source: Phonetica)
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In this study, articulation rates in American English are calculated from the automatic speech-to-text transcripts of more than 29,000 hours of video from local government and civic organization channels on YouTube from the 48 contiguous US states, containing more than 230 million individual word timings. Two questions are considered: are there regional differences in articulation rate? And do urban speakers articulate faster than rural speakers? The study presents several methodological innovations:...
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This study explores the organisation of other-initiated repair sequences in interactions involving people with right hemisphere communication disorder using conversation analysis. Two people with right hemisphere communication disorder caused by stroke and four of their familiar conversation partners were recorded in triadic interactions; 104 minutes of recordings were collected, and 28 other-initiated repair sequences were subjected to analysis. This included other-initiations of repair produced...
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We describe a diverse population of human T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic MHC-related protein 1 (MR1). The crystal structure of a TCR–MR1–antigen complex starkly contrasts with all other TCR–MHC and TCR–MHC-I-like complex structures. Namely, the TCR binds underneath the MR1 antigen-binding cleft, where contacts are dominated by the MR1 α3 domain. A similar pattern of reactivity was observed for diverse MR1-restricted TCRs from multiple...
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(Source: ScienceNOW)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(Source: ScienceNOW)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby triggering the type I interferon (IFN) response. Mitochondrial outer membrane permeabilization, which is required for mtDNA release, has been extensively studied in apoptotic cells, but little is known about its role in live cells. We found that oxidatively stressed mitochondria release short mtDNA fragments via pores formed by the voltage-dependent anion channel (VDAC) oligomers in the mitochondrial outer membrane....
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In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the...
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We describe a pattern of regulation in the host by the aryl hydrocarbon receptor (AhR) that is critically dependent on qualitative and quantitative sensing of P. aeruginosa quorum. QS molecules bind to AhR and distinctly modulate its activity. This is mirrored upon infection with P. aeruginosa collected from diverse growth stages and with QS mutants. We propose that by spying on bacterial quorum, AhR acts as a major sensor of infection dynamics, capable of orchestrating host defense according to...
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[SciDev.Net] Lower-income countries are increasingly facing a double blow from the impact of both undernutrition and obesity, which often coexist within the same community - and are even found within the same families or individuals. (Source: AllAfrica News: Health and Medicine)
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By 2030, nearly half of U.S. adults will be obese, including the nearly 1 in 4 who will have severe obesity. The obesity rate will surpass 50% in 29 states. (Source: Los Angeles Times - Science)
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Publication date: Available online 18 December 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Ramesh Vinayagam, Raja Selvaraj, Arivalagan Pugazhendhi, Thivaharan VaradavenkatesanAbstractAn environmentally sound approach towards the green synthesis of zinc oxide nanostructures has been achieved with an aqueous extract of Calliandra haematocephala leaves. The nanoparticles were characterized using various analytical techniques to substantiate the structural details. An...
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When changes in how Medicare reimburses for services took effect in skilled nursing facilities in October, we heard stories of speech-language pathologists who experienced job loss and changes in their pay or status. What will happen when similar changes hit the home health industry on Jan. 1? Listen in as we discuss how to show your value under the Patient-Driven Grouping Model, or PDGM. The new Medicare reimbursement model taking effect in home health might seem complicated and confusing. But...
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ConclusionHLA-F-AS1 promoted CRC progression via regulating miR-330-3p/PFN1 axis. (Source: Life Sciences)
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Publication date: Available online 18 December 2019Source: Life SciencesAuthor(s): Fereshteh Asgharzadeh, Milad Hashemzehi, Reyhaneh Moradi Marjaneh, Seyed Mahdi Hassanian, Gordon A. Ferns, Majid Khazaei, Amir AvanAbstractAimsAngiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) which have been used in the treatment of cardiovascular diseases, have also been shown to have anti-tumor effects against various cancers that include renal cancer. The aim of current paper...
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ConclusionElevated expression of circACAP2 in breast cancer tissues leads to malignant phenotype upon cancerous cells. CircACAP2-miR-29a/b-3p-COL5A1 axis leads to breast cancer tumorigenesis and could hopefully be a novel method for diagnosis and treatment for breast cancer. (Source: Life Sciences)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm...
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In conclusion, melatonin may regulate the activation of T/B cells, playing a critical role in the regulation of immune balance. (Source: Life Sciences)
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Publication date: Available online 18 December 2019Source: Journal of Theoretical BiologyAuthor(s): Jarmila NahálkováAbstractPIN7 is a protein-protein interaction network of seven pleiotropic proteins (TPPII, CDK2, MYBBP1A, p53, SIRT6, SIRT7, and CD147) with proposed multiple functions in the aging and age-related diseases including cancer and neurodegeneration. Since the animal and cellular models with downregulated or knockout TPPII, p53, SIRT6, SIRT7, and MYBBP1A expression levels demonstrate...
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We report the synthesis of four octahedral germanium(IV) complexes bearing acetylacetonato ligand, [GeIV(acac)3)]+, with different anions (3 – 6) using a streamlined synthetic approach. The compounds were structurally and electrochemically characterized using NMR, MS, X-ray crystallography, and cyclic voltammetry. The cyclic voltammogram of 3 – 5 revealed distinct irreversible peaks in the range of -0.9 to -1.3 V, corresponding to Ge(IV)/Ge(II) couple in DMSO. We explored the anticancer activity...
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This study interprets the theoretical basis of PMI-oriented cancer progression and targeting therapies in clinic.Graphical AbstractA study demonstrated and identified active protein-metabolite binding complexes through the affinity purification and followed by the successful identification and validation of the MTDH-cholesterol binding. Through the LC-MS-based metabolomics, we further defined the functional role of MTDH-cholesterol interaction in cancer cells. (Source: Chinese Chemical Letters)
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. (Source: Critical Reviews in Toxicology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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An international team of pathologists has identified a new protein often found on pleural mesothelioma tumor cells. The discovery could lead to a more accurate prognosis for patients and future treatment advances. Researchers found for the first time that mesothelioma patients expressing higher levels of the CD70 protein typically experience a much shorter survival, regardless of cell type or treatment type. “These markers might be useful for MPM [malignant pleural mesothelioma] prognostic evaluations,...
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[SciDev.Net] There is a lack of strategies to tackle chronic diseases such as cancer and heart disease in the African region, posing a key challenge for those working to improve healthcare on the continent, according to WHO director-general Tedros Adhanom Ghebreyesus. (Source: AllAfrica News: Health and Medicine)
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(The Wistar Institute) A Wistar study demonstrated that NAMPT, an enzyme critical for NAD+ biosynthesis, mediates selection of stem-like chemoresistant cells following cisplatin treatment. (Source: EurekAlert! - Biology)
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(Source: ScienceNOW)
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