Oncological outcomes of early stage glottic squamous cell carcinoma treated with transoral laser microsurgery

Oncological outcomes of early stage glottic squamous cell carcinoma treated with transoral laser microsurgery:

Publication date: Available online 28 November 2019
Source: American Journal of Otolaryngology
Author(s): Lei Lei, Daling Zhong, Jian Zou, Haiyang Wang, Hui Yang, Yu Zhao, Jun Liu, Danni Cheng, Fumei Wu

Abstract

Materials and methods

The records of patients treated with TLM with previously untreated early stage glottic squamous cell carcinoma were reviewed.

Results

A total of 201 patients were enrolled: 191 men (95.0%) and 10 women (4.98%). The anterior commissure (AC) was involved in 94 (47.8%) patients. The 3- and 5-year overall survival rates of all patients were 94.5% and 90.9%. The local recurrence rates were 30.8% in the AC involvement (AC+) group and 16.0% in the group without AC involvement (AC–). The mortality rates were 18.1% and 3.7% in the AC+ and AC– groups. The 3- and 5-year disease-free survival rates were lower in the AC+ group (89.1%, 82.5%) than that in AC– group (99.0%, 96.5%). Local recurrence rates were 25%, 22.7%, 23.4%, and 22.1% for Tis, T1a, T1b, and T2 lesions. The mortality rates were 0.0%, 4.6%, 12.8%, and 15.3%. Three- and 5-year disease-free survival rates did not differ significantly between the tumor stage subgroups. The mortality for patients with local recurrence was 22.2%, which was higher than that for those without recurrence. The organ preservation rate was 98.5%.

Purpose

This study was to assess the rates of oncological outcomes in patients with early stage glottic squamous cell carcinoma treated with transoral laser microsurgery (TLM).

Conclusion

AC involvement was a predictor of local recurrence, and its presence was associated with a reduced survival rate and increased mortality after TLM. TLM got high survival rate and low recurrence rate. The staging and oncological outcomes did not differ between tumor stage subgroups.