Abstract In genetic association studies, joint modeling of related traits/phenotypes can utilize the correlation between them and thereby provide more power and uncover additional information about genetic etiology. Moreover, detecting rare genetic variants are of current scientific interest as a key to missing heritability. Logistic Bayesian LASSO (LBL) has been proposed recently to detect rare haplotype variants using case‐control data, that is, a single binary phenotype. As there is currently...
22h
Abstract Background Although self‐employed persons have greater autonomy, schedule flexibility, and control over their work than employees, they may be among the most vulnerable workers due to the lack of social benefits and protection from labor law and regulations. We compared suicidal behaviors between the self‐employed and standardly employed workers. Methods This study used the 2008 Korean Community Health Survey data and included a total of 64 802 working population. Self‐employed...
22h
Stress-induced unfolding and fibrillation of insulin represent serious medical and biotechnological problems. Despite many attempts to elucidate the molecular mechanisms of insulin fibrillation, there is no general agreement on how this process takes place. Several previous studies suggested the importance of the C-terminal region of B-chain in this pathway. Therefore, we generated the T30R and K29R/T30R mutants of insulin B-chain. Recombinantly produced wild type (Wt) A-chain and mutant B-chains...
22h
COP I and COP II complexes are involved in the transport of proteins between the endoplasmic reticulum and the Golgi apparatus in eukaryotic cells. Formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a type I transmembrane protein. Oligomerization of p24 monomers was suggested to be mediated and/or stabilized via interactions within the transmembrane domain, and the p24 transmembrane helix appears to selectively bind a single sphingomyelin...
22h
Cardiovascular disease is often related to defects of sub-cellular components in cardiac myocytes, specifically in the dyadic cleft, which include changes in cleft geometry and channel placement. Modeling of these pathological changes requires both spatially resolved cleft as well as whole cell level descriptions. We use a multi-scale model to create dyadic structure-function relationships in order to explore the impact of molecular changes on whole cell electrophysiology and calcium cycling. This...
22h
Abstract Purpose The aims of the study were to compare the risk of complications and the quality of life in patients with corticotrope deficiency, who fasted during Ramadan. Both hydrocortisone and prednisolone were compared as treatments. Methods A randomized double-blind crossover clinical trial conducted in the department of Endocrinology of the University...
22h
Background In Canada, the Canadian Agency for Drugs and Technologies in Health (CADTH) evaluates and makes recommendations for the reimbursement of cancer drugs. One component of its recommendation is based on an economic evaluation, which typically takes the form of a cost‐utility analysis. A cost‐utility analysis measures the effects of competing therapies with quality‐adjusted life‐years (QALYs). The data for this calculation typically come from generic, preference‐based measures of health‐related...
23h
Abstract Human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) is a newly identified member of B7 family; HHLA2 protein expression has been suggested to be increased levels in many kinds of human cancers. However, HHLA2 protein expression in gastric cancer tissues and its clinical significance are still unknown. The purpose of this study was to investigate the HHLA2 protein expression pattern in gastric cancer tissues and the correlation between HHLA2...
23h
The Angle Orthodontist, Ahead of Print.
23h
In this meta-analysis of 39 samples, we synthesize the evidence on parenting behavior and the development of children’s language skills.
23h
Background Later line chemotherapy (≥2nd lines) such as Docetaxel or immunotherapy is frequently used. As the life expectancy of lung cancer patients is getting longer, we need to provide more treatment options. Other treatment options are not well documented except for Doxetaxel and immunotherapy. Therefore, the efficacy of paclitaxel plus TS1 (TTS1) is warranted. Methods We retrospectively reviewed the chart records...
23h
A new tanaidacean, Tanaella quintanai sp. nov., is described based on specimens collected from depths of 1,598 to 2,853 m during 2014–2015. The new species appears to be most closely related to the western Atlantic species, T. kroyeri and T. mclellandi. Tanaella quintanai can be separated from the two former, as well as from the other members of the genus by a combination of characters, including (1) a labium with apical lobe bearing one blunt seta (2) a cheliped with the inner margin of the dactylus...
23h
The hypothalamus has an integral role in energy homeostasis regulation, and its dysfunctions lead to the development of type 2 diabetes (T2D). Physical activity positively affects the prevention and treatment of T2D. However, there is not much information on the adaptive mechanisms of the hypothalamus. In this study, RNA sequencing was used to determine how acute exercise affects hypothalamic transcriptome from both type 2 diabetic Goto-Kakizaki (GK) and control Wistar rats with or without a single...
23h
Coral reef resilience depends on the balance between carbonate precipitation, leading to reef growth, and carbonate degradation, for example, through bioerosion. Changes in environmental conditions are likely to affect the two processes differently, thereby shifting the balance between reef growth and degradation. In cold-water corals estimates of accretion-erosion processes in their natural habitat are scarce and solely live coral growth rates were studied with regard to future environmental changes...
23h
Background Chloroplast genomes provide insufficient phylogenetic information to distinguish between closely related sugarcane cultivars, due to the recent origin of many cultivars and the conserved sequence of the chloroplast. In comparison, the mitochondrial genome of plants is much larger and more plastic and could contain increased phylogenetic signals. We assembled a consensus reference mitochondrion with Illumina TruSeq synthetic long reads and Oxford Nanopore Technologies MinION long reads....
23h
Estimating flowering transition dates from status-based phenological observations: a test of methods
The scale of phenological research has expanded due to the digitization of herbarium specimens and volunteer based contributions. These data are status-based, representing the presence or absence of a specific phenophase. Modelling the progress of plant dormancy to growth and reproduction and back to dormancy requires estimating the transition dates from these status-based observations. There are several methods available for this ranging from statistical moments using the day of year to newly introduced...
23h
Evolutionary relationships among plants have been inferred primarily using chloroplast data. To date, no study has comprehensively examined the plastome for gene tree conflict. Using a broad sampling of angiosperm plastomes, we characterize gene tree conflict among plastid genes at various time scales and explore correlates to conflict (e.g., evolutionary rate, gene length, molecule type). We uncover notable gene tree conflict against a backdrop of largely uninformative genes. We find alignment length...
23h
Plaque assay has been used for a long time to determine infectious titers and characterize prokaryotic and eukaryotic viruses forming plaques. Indeed, plaque morphology and dimensions can provide information regarding the replication kinetics and the virulence of a particular virus. In this work, we present ViralPlaque, a fast, open-source and versatile ImageJ macro for the automated determination of viral plaque dimensions from digital images. Also, a machine learning plugin is integrated in the...
23h
In the present study, we established that miR‐204‐5p exhibited tumor‐suppressive action via regulating the levels of interleukin‐11 and led to the invasion and progression of esophageal cancer. These results provide evidence for the function of miR‐204‐5p in esophageal squamous cell carcinoma (ESCC), and miR‐204‐5p may be a target for ESCC therapy in the future. Abstract Esophageal cancer (EC) is the world's eighth most common malignant neoplasm and is ranked as the sixth leading cause of death...
23h
Our studies have demonstrated that long noncoding RNA lncrps25 is required for motor neuron development and axonal growth through regulating the expression of olig2. Abstract lncrps25 is an intergenic long noncoding RNA (lncRNA), which is location close to rps25 (ribosomal protein S25) gene, is reported share high conserved sequence with NREP (neuronal regeneration‐related protein) 3′‐untranslated region. The function and mechanism of most of the lncRNA in embryo development remain largely unknown....
23h
This study revealed that immature rats were more sensitive than adult rats to bitterness and thus dislike bitter tastes more than adults do. The downregulated of TRPM5 protein in female adult rats compared with female immature rats and in male adult rats compared with male immature rats may be associated with it. Abstract Children are more sensitive than adults to bitterness and thus dislike bitter tastes more than adults do. However, why children are more sensitive to bitterness has never been...
23h
Nuclear enriched abundant transcript 1 (NEAT1) could be a sponge for microRNA‐204 (miR‐204) and inhibits its level to upregulate ATG3 expression. We demonstrated that miR‐204 mimics also attenuated tumor autophagy. And rescue assays demonstrated that NEAT1 promotes hepatocellular carcinoma (HCC) autophagy through modulating miR‐204/ATG3 pathway. Abstract Long noncoding RNAs (lncRNAs) has been acknowledged in tumorigenesis gradually because of the great importance in different cancers. LncRNA...
23h
Nrf2–ARE signaling pathway mediates cellular oxidative stress response. Nrf2 is a transcription factor that drives the transcription of various cytoprotective proteins. It is regulated by an intricate network of other proteins that ensure appropriate cellular stress response as a function punctual demands. Abstract Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant titer. Toxic insults and many other diseased conditions are mediated through the formation...
23h
Droplet‐digital polymerase chain reaction (ddPCR) technique was set up to detect/quantify Merkel cell polyomavirus (MCPyV) DNA in clinical specimens, including chorionic villi and peripheral blood mononuclear cells (PBMCs) from spontaneous abortion (SA)‐affected females. This ddPCR assay showed high accuracy, sensitivity and specificity in detecting MCPyV DNA in clinical samples. MCPyV gene expression analysis by quantitative PCR for the large T antigen (LT) and viral capsid protein 1 (VP1) showed...
23h
Therapy induced senescence by Abrus agglutinin (AGG) requires autophagy. Silent mating type information regulation 1 (SIRT1) regulates AGG‐induced autophagy and senescence. SIRT1 deacetylates lysosome‐associated membrane protein 1 (LAMP1) to induce lipophagy. Lipophagy‐dependent free fatty acid (FFA) accumulation promotes reactive oxygen species (ROS) to influence senescence Abstract Therapy‐induced senescence in cancer cells is an irreversible antiproliferative state, which inhibits tumor...
23h
Our findings delineate the stemness‐inhibitory mechanism of miR‐203 in human CRC cells. Abstract The interaction between hyaluronan and CD44, an important cancer stem‐cell marker, stimulates various tumor cell‐specific functions such as the stemness of tumor cells. microRNA‐203 (miR‐203) can be downregulated by this interaction in human colorectal cancer (CRC) cells, which increases their stemness; however, the underlying mechanism is not yet defined. Here, we show that overexpression and sequestration...
23h
In granulosa cells of bovine ovarian follicles, the expression of TLR2/4 shows a tendency to increase with follicular growth. The suitable concentration of FSH stimulates granulosa cells to release HMGB1, which interact with TLR2/4 and activate the downstream signaling pathway to secrete cytokines involved in innate immunity, follicular dominance, and ovulation. We speculate that the underlying mechanism is related to PKC and Ca2+. Abstract Toll‐like receptors (TLRs) are present in the ovaries...
23h
Abstract Background The current classifications of adolescent idiopathic scoliosis (AIS) aim to guide surgical decision making. However, variance exists within treatment recommendations and suboptimal outcomes have been observed while following these guidelines based on two-dimensional images. We used previously developed 3D classification for right thoracic AIS patients and aimed to determine the variation in surgical decision making...
23h
Abstract Purpose This study examined for factors contributing to postoperative pain in adolescent idiopathic scoliosis (AIS), including those of sagittal alignment and lumbar disc degeneration. Methods A total of 101 consecutive patients who underwent posterior spinal fusion for AIS and who were followed for a minimum of 2 years were included in this investigation....
23h
Abstract Purpose Incidental durotomy (ID) is a complication occurring in 4–17% of decompressive spinal surgeries. Persisting CSF leakage can occur even after ID repair and requires revision surgery. Prolonged flat bed rest (BR) to reduce the incidence of persisting CSF leakage is frequently applied but highly debated. A randomized controlled trial comparing prolonged BR versus early ambulation after ID repair is lacking. The aim of this...
23h
Abstract Purpose The aim of this study was to systematically investigate whether, and to what extent, the detection of thyroid autoimmunity during pregnancy and in the weeks after childbirth is associated with an increased risk of developing post-partum depression (PPD), a condition associated with possible adverse outcomes for both mother and offspring. We performed a systematic review and meta-analysis of longitudinal studies, assessing...
23h
Here is brief teaching video about rare leukodystrophy, Pelizaeus Merzbacher Disease Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
23h
Viruses, Vol. 11, Pages 893: Gray (Oreochromis niloticus x O. aureus) and Red (Oreochromis spp.) Tilapia Show Equal Susceptibility and Proinflammatory Cytokine Responses to Experimental Tilapia Lake Virus Infection Viruses doi: 10.3390/v11100893 Authors: Kizito Kahoza Mugimba Shlomit Tal Saurabh Dubey Stephen Mutoloki Arnon Dishon Øystein Evensen Hetron M. Munang’andu Tilapia is the second most farmed fish species after carp in the world. However, the production has...
23h
More than 50% of Qatari adults are physically inactive. The workplace is an excellent environment to implement cost-effective, efficient behavioural physical activity (PA) interventions to increase PA. This st...
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