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Interference with the Bromodomain Epigenome Readers Drives p21 Expression and Tumor Senescence

Publication date: Available online 29 June 2019Source: Cancer LettersAuthor(s): Liana P. Webber, Veronica Q. Yujra, Pablo A. Vargas, Manoela D. Martins, Cristiane H. Squarize, Rogerio M. CastilhoAbstractHead and neck cancer (HNSCC) are one of the most common solid malignancies of the world, being responsible for over 350,000 deaths every year. Much of the complications in managing and treating HNSCC advent from the complex genetic and epigenetic landscape of the disease. Emerging information has...

ScienceDirect Publication: Cance...

Sun Jun 30, 2019 15:39

CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression

Publication date: Available online 27 June 2019Source: Cancer LettersAuthor(s): Fuxin Zheng, Miao Wang, Yawei Li, Chao Huang, Dan Tao, Fei Xie, Hui Zhang, Jiayin Sun, Chuanhua Zhang, Chaohui Gu, Zhendi Wang, Guosong JiangAbstractAccumulating evidences suggest that circular RNAs play vital roles in human cancers. Previously, we found that circHIPK3 suppressed invasion of bladder cancer cells via sponging miR-558 and downregulating heparanase expression. In this study, we discovered that a circular...

ScienceDirect Publication: Cance...

Fri Jun 28, 2019 18:55

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