Systems approach reveals photosensitivity and PER2 level as determinants of clock‐modulator efficacy

Dae Wook Kim, Cheng Chang, Xian Chen, Angela C Doran, Francois Gaudreault, Travis Wager, George J DeMarco, Jae Kyoung Kim

e8838 | First Published: 08 July 2019

 

The study identifies the sources of the inter‐ and intraspecies variability in the modulation of circadian phase by CK1δ/ε inhibition: photosensitivity and PER2 abundance, and proposes a personalized chronotherapy to treat circadian disruption.