Cancer Cell,

RAC1^P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

Publication date: Available online 27 June 2019Source: Cancer CellAuthor(s): Daniël A. Lionarons, David C. Hancock, Sareena Rana, Philip East, Christopher Moore, Miguel M. Murillo, Joana Carvalho, Bradley Spencer-Dene, Eleanor Herbert, Gordon Stamp, Djamil Damry, Dinis P. Calado, Ian Rosewell, Ralph Fritsch, Richard R. Neubig, Miriam Molina-Arcas, Julian DownwardSummaryRAC1 P29 is the third most commonly mutated codon in human cutaneous melanoma, after BRAF V600 and NRAS Q61. Here, we study the role...

ScienceDirect Publication: Cancer Cell

Fri Jun 28, 2019 16:31

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

Publication date: Available online 27 June 2019Source: Cancer CellAuthor(s): Andrew Fedoriw, Satyajit R. Rajapurkar, Shane O'Brien, Sarah V. Gerhart, Lorna H. Mitchell, Nicholas D. Adams, Nathalie Rioux, Trupti Lingaraj, Scott A. Ribich, Melissa B. Pappalardi, Niyant Shah, Jenny Laraio, Yan Liu, Michael Butticello, Chris L. Carpenter, Caretha Creasy, Susan Korenchuk, Michael T. McCabe, Charles F. McHugh, Raman NagarajanSummaryType I protein arginine methyltransferases (PRMTs) catalyze asymmetric...

ScienceDirect Publication: Cancer Cell

Fri Jun 28, 2019 16:31

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