Elsevier Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Fibroblasts in cancer: Defining target structures for therapeutic intervention

Publication date: Available online 29 June 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Maximilian Boesch, Florent Baty, Holger Rumpold, Sieghart Sopper, Dominik Wolf, Martin H. BrutscheAbstractThe functional importance of the tumor stroma for cancer growth and progression is increasingly recognized, but has not resulted in notable therapeutic developments yet. Within the mesenchymal tumor microenvironment, cancer-associated fibroblasts take the center stage and fuel...

ScienceDirect Publication: Bioch...

Sun Jun 30, 2019 14:52

Comprehensive elaboration of database resources utilized in next-generation sequencing-based tumor somatic mutation detection

Publication date: Available online 29 June 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Peng Gao, Rui Zhang, Jinming LiAbstractThe rapid evolution of next-generation sequencing (NGS)-based tumor genomic profile detection and the emergence of molecularly targeted therapies have enabled precision oncology. In NGS-based analysis, various types of databases have been developed to perform different functions. However, many problems still exist when using these public databases....

ScienceDirect Publication: Bioch...

Sun Jun 30, 2019 14:52

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