The effect of peripheral blood eosinophilia on inflammatory markers in asthmatic patients with lower respiratory tract infections.

Cag Y1, Pacal Y2, Gunduz M2, Isik S2, Kertmen BA2, Toprak N2, Ozaydin SE2, Ozcetin M3, Kut A4.

Author information

1

1 Department of Paediatrics, University of Health Sciences Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey.

2

2 Department of Paediatric Pulmonology, Health Sciences Sureyyapasa Chest Disease and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.

3

3 Department of Paediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

4

4 Department of Paediatric Pulmonology, Medical Faculty, Maltepe University, Istanbul, Turkey.

Abstract

BACKGROUND:

To investigate the behaviour of the inflammatory marker neutrophil-to-lymphocyte ratio (NLR) in the presence of peripheral blood eosinophilia (PBE) in paediatric asthma patients with lower respiratory tract (LRT) infections.

METHODS:

This retrospective study enrolled consecutive patients aged ≥5 years who were diagnosed with asthma and whose haemogram values were available. The patients were further subdivided based on the presence or absence of LRT infections and allergies. NLR and C-reactive protein (CRP) were evaluated in relation to the presence or absence of PBE (≥4% eosinophils).

RESULTS:

A total of 991 patients were enrolled in the study. Patients with LRT infections had significantly higher leucocyte and neutrophil counts, a greater NLR and a higher level of CRP compared with patients without LRT infections. Overall, patients with PBE had significantly lower NLRs and CRP regardless of the presence or absence of an LRT infection. The PBE percentage showed moderate inverse correlations with NLR ( r = -0.34) and CRP ( r = -0.20).

CONCLUSION:

The presence of PBE was significantly associated with lower NLR and CRP regardless of the presence or absence of an infectious condition.

KEYWORDS:

Lower respiratory tract infection; allergic asthma; neutrophil-to-lymphocyte ratio; peripheral blood eosinophilia

PMID:

 

31006357

 

DOI:

 

10.1177/0300060519844859

Similar articles