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Δευτέρα, 29 Απριλίου 2019

PLoS Genetics: New Articles by Saber Qanbari, Carl-johan Rubin, Kh.. - 9m ago Preview
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by Saber Qanbari, Carl-Johan Rubin, Khurram Maqbool, Steffen Weigend, Annett Weigend, Johannes Geibel, Susanne Kerje, Christine Wurmser, Andrew Townsend Peterson, I. Lehr Brisbin Jr., Ruedi Preisinger, Ruedi Fries, Henner Simianer, Leif Andersson
We carried out whole genome resequencing of 127 chicken including red jungle fowl and multiple populations of commercial broilers and layers to perform a systematic screening of adaptive changes in modern chicken (Gallus gallus domesticus). We uncovered >21 million high quality SNPs of which 34% are newly detected variants. This panel comprises >115,000 predicted amino-acid altering substitutions as well as 1,100 SNPs predicted to be stop-gain or -loss, several of which reach high frequencies. Signatures of selection were investigated both through analyses of fixation and differentiation to reveal selective sweeps that may have had prominent roles during domestication and breed development. Contrasting wild and domestic chicken we confirmed selection at the BCO2 and TSHR loci and identified 34 putative sweeps co-localized with ALX1KITLGEPGRIGF1DLK1JPT2CRAMP1and GLI3, among others. Analysis of enrichment between groups of wild vs. commercials and broilers vs. layers revealed a further panel of candidate genes including CORINSKIV2L2 implicated in pigmentation and LEPRMEGF10 and SPEF2, suggestive of production-oriented selection. SNPs with marked allele frequency differences between wild and domestic chicken showed a highly significant deficiency in the proportion of amino-acid altering mutations (P

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